Lloyd Trotman
Professor
Cancer Center Associate Director of Education
Ph.D., University of Zurich, 2001
[email protected] | 516-367-5054
We pioneered generation of a unique genetic mouse model for therapy and analysis of metastatic prostate cancer. Recently, we developed 3-dimensional whole organ imaging technology that allows us to visualize cancer and metastatic progression in its native environment and at single cell resolution. Now, we use this platform to understand the role of nerves in tumor metastasis, and to develop novel therapeutic interventions against lethal disease.
Understanding Metastasis鈥揇esigning models of lethal cancer
The Trotman lab have developed the RapidCaP model system to study metastatic prostate cancer in vivo. This approach allows them to visualize and probe metastasis biology in the fully native and immune competent setting. They combine this with 3D whole organ imaging at single cell resolution to define the stepwise progression from primary tumor escape to colonization of metastatic sites such as bone, liver and lung.
The Neuro-Metastasis Interface
A major challenge in metastasis research is the identification of factors that control progression of non life-threatening tumors to lethal metastatic disease. In spite of much knowledge on the role of tumor neuron interactions in primary prostate cancer, the role of neurons in metastatic prostate cancer remains to be defined. They use their whole organ imaging platform on metastatic tumors to map and manipulate interactions between the peripheral nervous system and metastatic lesions in collaboration with neuroscientists at CSHL.
Therapy of Lethal Prostate Cancer
They use the RapidCaP model to understand evolution of metastasis and therapy resistance in order to advance the 70 year old standard of care, anti-hormonal therapy, which is not curative. They combine three cutting edge approaches to test novel therapeutic concepts, in vivo: Single cell analysis of metastatic therapy resistance, dietary control of prostate cancer progression, discovery of therapeutic targets in genome wide screens.
2022 Member, AACR Science Education and Career Advancement Committee
2021 Editorial Board member, The Journal of Cell Biology, Rockefeller Press, NY
2020 Editorial Advisory Board member, The EMBO Journal
2014 Pershing Square Sohn Prize
2014 American Cancer Society Scholar
2008 V Foundation Scholar
2007 Rita Allen Foundation Scholar
2006 ASCB Merton R. Bernfield Memorial Award
The science of storytelling
July 23, 2026
Science journalists learn the value of visual storytelling in this intensive filmmaking workshop.
The Unspoken Truth: A Dialogue on Prostate Cancer
June 30, 2026
Lloyd Trotman joins community leaders to discuss prostate cancer genetics, patient outcomes, and the importance of early screening.
From lab discovery to patient care
February 17, 2026
Professor Lloyd Trotman calls an upcoming clinical study 鈥渢he most important and defining moment in my career at the Lab.鈥
The journey: One lab鈥檚 long winding road to cancer discovery
October 15, 2025
Decades of diligent research and a measured approach have led CSHL Professor Lloyd Trotman from a new mouse model to breakthroughs in men鈥檚 health.
From finance to restaurateur to men鈥檚 health advocate
April 24, 2025
At just 48, Tom Milana was diagnosed with prostate cancer. 10 years later he is making a big impact on prostate cancer research and men鈥檚 health.
At the Lab: A vitamin for prostate cancer
April 8, 2025
For the Season 2 premiere of our podcast, we sit down with CSHL Professor Lloyd Trotman to discuss what could be a major breakthrough in men鈥檚 health.
Are pro-oxidants anti-prostate cancer?
January 7, 2025
New research from CSHL Professor Lloyd Trotman offers men of all ages a look inside the possible future of prostate cancer treatment and prevention.
Vitamin K supplement slows prostate cancer in mice
October 24, 2024
The finding from CSHL Professor Lloyd Trotman and his team sets the stage for pilot studies in human prostate cancer patients.
Bite into this diet and disease quiz
July 5, 2023
Test your knowledge of how diet and nutrition affect health and disease with this short quiz.
Cancer has a lot of nerve
August 22, 2022
Tumors recruit the nervous system to help them spread. Scientists are looking for ways to stop it.
All Publications
14 Jul 2025 | Genes & Development
Kuang, Shan; Swamynathan, Manojit; Trotman, Lloyd;
May 2025 | Bioorganic and Medicinal Chemistry | 122:118136
Wang, Hehe; Zhu, Chuanzhou; Swamynathan, Manojit; Rajput, Shubhra; Jayanetti, Kalani; Rendina, Dominick; Takemura, Kathryn; Bogdan, Diane; Wang, Liqun; Rizzo, Robert; Kaczocha, Martin; Trotman, Lloyd; Bialkowska, Agnieszka; Ojima, Iwao;
20 Dec 2024 | iScience | 27(12):111278
Jun, H; Paulo, J; Appleman, V; Yaron-Barir, T; Johnson, J; Yeo, A; Rogers, V; Kuang, S; Varma, H; Gygi, S; Trotman, L; Charest, A;
25 Oct 2024 | Science | 386(6720):eadk9167
Swamynathan, Manojit; Kuang, Shan; Watrud, Kaitlin; Doherty, Mary; Gineste, Charlotte; Mathew, Grinu; Gong, Grace; Cox, Hilary; Cheng, Eileen; Reiss, David; Kendall, Jude; Ghosh, Diya; Reczek, Colleen; Zhao, Xiang; Herzka, Tali; Špokait臈, Saul臈; Dessus, Antoine; Kim, Seung; Klingbeil, Olaf; Liu, Juan; Nowak, Dawid; Alsudani, Habeeb; Wee, Tse-Luen; Park, Youngkyu; Minicozzi, Francesca; Rivera, Keith; Almeida, Ana; Chang, Kenneth; Chakrabarty, Ram; Wilkinson, John; Gimotty, Phyllis; Diermeier, Sarah; Egeblad, Mikala; Vakoc, Christopher; Locasale, Jason; Chandel, Navdeep; Janowitz, Tobias; Hicks, James; Wigler, Michael; Pappin, Darryl; Williams, Roger; Cifani, Paolo; Tuveson, David; Laporte, Jocelyn; Trotman, Lloyd;
4 Apr 2024 | Cancer Discovery | 14(4):669-673
Amit, Moran; Anastasaki, Corina; Dantzer, Robert; Demir, Ihsan; Deneen, Benjamin; Dixon, Karen; Egeblad, Mikala; Gibson, Erin; Hervey-Jumper, Shawn; Hondermarck, Hubert; Magnon, Claire; Monje, Michelle; Na'ara, Shorook; Pan, Yuan; Repasky, Elizabeth; Scheff, Nicole; Sloan, Erica; Talbot, Sebastien; Tracey, Kevin; Trotman, Lloyd; Valiente, Manuel; Van Aelst, Linda; Venkataramani, Varun; Venkatesh, Humsa; Vermeer, Paola; Winkler, Frank; Wong, Richard; Gutmann, David; Borniger, Jeremy;
27 Feb 2024 | Cancer Cell | :S1535-6108(24)00048
Colucci, Manuel; Zumerle, Sara; Bressan, Silvia; Gianfanti, Federico; Troiani, Martina; Valdata, Aurora; D'Ambrosio, Mariantonietta; Pasquini, Emiliano; Varesi, Angelica; Cogo, Francesca; Mosole, Simone; Dongilli, Cristina; Desbats, Maria; Contu, Liliana; Revankdar, Ajinkya; Chen, Jingjing; Kalathur, Madhuri; Perciato, Maria; Basilotta, Rossella; Endre, Laczko; Schauer, Stefan; Othman, Alaa; Guccini, Ilaria; Saponaro, Miriam; Maraccani, Luisa; Bancaro, Nicolò; Lai, Ping; Liu, Lei; Pernigoni, Nicolò; Mele, Federico; Merler, Sara; Trotman, Lloyd; Guarda, Greta; Calì, Bianca; Montopoli, Monica; Alimonti, Andrea;
2024 | Cancers | 16(1):60
Swamynathan, Manojit; Mathew, Grinu; Aziz, Andrei; Gordon, Chris; Hillowe, Andrew; Wang, Hehe; Jhaveri, Aashna; Kendall, Jude; Cox, Hilary; Giarrizzo, Michael; Azabdaftari, Gissou; Rizzo, Robert; Diermeier, Sarah; Ojima, Iwao; Bialkowska, Agnieszka; Kaczocha, Martin; Trotman, Lloyd;
2023 | PLoS ONE | 18(10):e0292483
Hillowe, Andrew; Gordon, Chris; Wang, Liqun; Rizzo, Robert; Trotman, Lloyd; Ojima, Iwao; Bialkowska, Agnieszka; Kaczocha, Martin; Pizzo, Salvatore;
Aug 2023 | Nature Cancer | 4(8):1102-1121
Brina, Daniela; Ponzoni, Adele; Troiani, Martina; Calì, Bianca; Pasquini, Emiliano; Attanasio, Giuseppe; Mosole, Simone; Mirenda, Michela; D'Ambrosio, Mariantonietta; Colucci, Manuel; Guccini, Ilaria; Revandkar, Ajinkya; Alajati, Abdullah; Tebaldi, Toma; Donzel, Deborah; Lauria, Fabio; Parhizgari, Nahjme; Valdata, Aurora; Maddalena, Martino; Calcinotto, Arianna; Bolis, Marco; Rinaldi, Andrea; Barry, Simon; Rüschoff, Jan; Sabbadin, Marianna; Sumanasuriya, Semini; Crespo, Mateus; Sharp, Adam; Yuan, Wei; Grinu, Mathew; Boyle, Alexandra; Miller, Cynthia; Trotman, Lloyd; Delaleu, Nicolas; Fassan, Matteo; Moch, Holger; Viero, Gabriella; de Bono, Johann; Alimonti, Andrea;
4 Apr 2023 | Analytical Chemistry | 95(13):5661-5670
Chung, Taemoon; Garcia, Libia; Swamynathan, Manojit; Froeling, Fieke; Trotman, Lloyd; Tuveson, David; Lyons, Scott;