structural biology Archives | ��ϳԹ��Դ

Joshua-Tor joins American Academy of Sciences and Letters

Samuel Diamond — Thu, 13 Nov 2025 12:38:22 +0000

��ϳԹ��Դ (CSHL) Director of Research Leemor Joshua-Tor has been inducted to the American Academy of Sciences and Letters. The W.M. Keck Professor of Structural Biology and HHMI investigator was honored for her fundamental biology research during a ceremony at the historic Decatur House museum, one of the oldest homes in Washington, D.C....

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A doorstop for the brain’s electrical gates

Jennifer Michalowski — Wed, 29 Oct 2025 16:00:04 +0000

Nature, reveals the molecular mechanisms that keep the brain’s NMDA receptors fully or partially open." data-description="Image of NMDA receptors in different positions" />As information zings from cell to cell inside the brain, bursts of electricity spur its transmission. At ��ϳԹ��Դ (CSHL), scientists have turned their attention to the tiny pores that let charged ions enter a cell—and the molecular gatekeepers that help control them. CSHL structural biologist Hiro Furukawa studies NMDA receptors (NMDARs). These...

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Plate Race 2025

Communications Department — Mon, 25 Aug 2025 11:30:26 +0000

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Licensed to live

Jennifer Michalowski — Tue, 29 Jul 2025 11:30:21 +0000

The DNA packed inside every human cell contains instructions for life, written in billions of letters of genetic code. Every time a cell divides, the complete code, divided among 46 chromosomes, must be faithfully copied. This staggering task happens over and over with extraordinary precision. Decades of research have revealed how dozens of proteins work...

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A recipe to reverse cancer’s sweet tooth

Nick Wurm — Mon, 16 Jun 2025 11:30:58 +0000

Sometimes sugar isn’t so sweet. Sometimes, it’s downright deadly. Glycation occurs when an excess of sugars called reducing sugars attach to important proteins in the body. The process has been linked to diabetes and obesity. It’s usually something to avoid, and the body relies on the FN3K kinase to break glycation down. But cancer flips...

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At the Lab: The human Microprocessor

Communications Department — Tue, 27 May 2025 11:30:11 +0000

In biology, the phrase “molecular machinery” gets tossed around pretty regularly. But this week At the Lab, we’re talking about a particular molecular machine that truly earns the title. Join CSHL Professor & HHMI Investigator Leemor Joshua-Tor as she breaks down the crucial functions of Microprocessor.

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Ketamine: From club drug to antidepressant?

Samuel Diamond — Fri, 14 Feb 2025 16:00:46 +0000

AI generated voice Ketamine has received a Hollywood makeover. It used to be known as a rave drug (street name special K) and cat anesthetic. However, in recent years, some doctors have prescribed ketamine to treat conditions from post-traumatic stress disorder to depression. “The practice is not without controversy,” notes ��ϳԹ��Դ (CSHL)...

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Eyes on the atom

Communications Department — Tue, 31 Dec 2024 12:30:31 +0000

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The Microprocessor inside you

Jennifer Michalowski — Mon, 02 Dec 2024 12:30:49 +0000

It’s a big year for microRNAs. The 2024 Nobel Prize in Physiology or Medicine went to Victor Ambros and Gary Ruvkun, who discovered the first microRNA in 1993. Today, we know that humans make more than 1,000 different microRNAS. These molecules are critical for building and maintaining healthy bodies, so it’s crucial that they’re made...

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Putting out a brain on fire

Jen A. Miller — Thu, 17 Oct 2024 11:30:47 +0000

Imagine you wake up in a hospital without a single memory of the last month. Doctors say you had a series of violent episodes and paranoid delusions. You’d become convinced you were suffering from bipolar disorder. Then, after a special test, a neurologist diagnoses you with a rare autoimmune disease called anti-NMDAR encephalitis. This is...

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This protein does “The Twist”

Luis Sandoval — Wed, 31 Jul 2024 15:00:56 +0000

Proteins are constantly performing a kind of dance. They move and contort their bodies to fulfill specific functions inside our bodies. The NMDAR protein executes an especially hard dance routine in our brains. One wrong step can lead to a range of neurological disorders. NMDAR binds to the neurotransmitter, glutamate, and another compound, glycine. These...

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Dream big: A powerful vision for CSHL research

Jennifer Michalowski — Tue, 02 Jan 2024 12:30:26 +0000

Leemor Joshua-Tor describes her new role as director of research at ��ϳԹ��Դ (CSHL) in no uncertain terms. “I am going to enable our faculty to carry out their dreams,” she says. CSHL scientists tend to dream big. Joshua-Tor knows that to map the brain’s circuits, transform our understanding of cancer biology, and...

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The dance of epigenetic inheritance

Communications Department — Wed, 27 Sep 2023 11:30:43 +0000

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How plants pass down genetic memories

Jennifer Michalowski — Mon, 28 Aug 2023 15:00:16 +0000

Arabidopsis thaliana is a plant species widely used to make fundamental biological discoveries. With the help of this versatile test subject, CSHL scientists have now dug up the secrets of a process that helps control inheritance." data-description="" />When organisms pass their genes on to future generations, they include more than the code spelled out in DNA. Some also pass along chemical markers that instruct cells how to use that code. The passage of these markers to future generations is known as epigenetic inheritance. It’s particularly common in plants. So, significant findings here...

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This eight-armed octopus-like pore perceives taste

Jennifer Michalowski — Fri, 14 Jul 2023 11:30:33 +0000

The neurons in our bodies are dotted with tiny pores that let essential molecules pass in and out of our cells. Neurons need these channels to send the signals that allow us to move, think, and perceive the world around us. Now, structural biologists at ��ϳԹ��Դ (CSHL) have captured never-before-seen images of...

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A molecular machine’s secret weapon exposed

Luis Sandoval — Thu, 23 Feb 2023 16:00:39 +0000

RNAs are having a moment. The foundation of COVID-19 vaccines, they’ve made their way from biochemistry textbooks into popular magazines and everyday discussions. Entire companies have launched dedicated to RNA research. These tiny molecules are traditionally known for helping cells make proteins, but they can do much more. They come in many shapes and sizes,...

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A new look at brain function and psychiatric disorders

Jennifer Michalowski — Wed, 02 Nov 2022 11:30:23 +0000

New images from scientists at ��ϳԹ��Դ (CSHL) reveal for the first time the three-dimensional structures of a set of molecules critical for healthy brain function. The molecules are members of a family of proteins in the brain known as NMDA receptors, which mediate the passage of essential signals between neurons. The detailed...

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Mapping out new routes to treat brain disorders

Daniel Dunaief — Fri, 10 Jun 2022 14:00:01 +0000

��ϳԹ��Դ (CSHL) Professor Hiro Furukawa takes an architectural approach to brain research. He creates structural 3D maps of important proteins that malfunction in brain disorders. Furukawa has zeroed in on a protein called the NMDA (for N-methyl-D-aspartate) receptor that plays a key role in learning and memory. The NMDA receptor acts as...

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Decoding how a protein on the move keeps cells healthy

Nick Wurm — Tue, 31 May 2022 12:00:07 +0000

Cells produce proteins like little factories. But if they make too much at the wrong times it can lead to diseases like cancer, so they control production with a process called RNA interference (RNAi). As of July 2021, several drugs already take advantage of RNAi to treat painful kidney and liver diseases—with another seven in...

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Open access: The pathway to successful collaborations

Jasmine Lee — Thu, 30 Dec 2021 14:00:14 +0000

The birth and evolution of open access data banks” Before the age of modern cloud computing and the Internet, collecting and distributing scientific data was a challenging task. Researchers from different countries had their own ways of cataloging their findings. Computers were rare, expensive, and inaccessible. The ��ϳԹ��Դ (CSHL) June 1971 symposium,...

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structural biology Archives | ���ϳԹ���Դ