single cell sequencing Archives | ��ϳԹ��Դ

SBS awards honorary degree to James H. Eberwine

Communications Department — Thu, 07 May 2026 11:30:26 +0000

The ��ϳԹ��Դ (CSHL) School of Biological Sciences has awarded an honorary Doctor of Science degree to molecular neuroscientist James H. Eberwine, Ph.D. Eberwine is a professor of systems pharmacology and translational therapeutics at the University of Pennsylvania, where he also serves as co-director of the Penn Program in Single Cell Biology and...

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You’ve never seen corn like this before

Margaret Osborne — Mon, 15 Sep 2025 11:30:56 +0000

Plant stem cells are crucial for the world’s food supply, animal feed, and fuel production. They lay the foundation for how plants grow. Yet, much about these mysterious building blocks remains unknown. Previous analyses have failed to locate many of the important genes that regulate how these cells function. Now, for the first time, Cold...

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The curious immune cells caught between worlds

Luis Sandoval — Tue, 24 Sep 2024 15:00:58 +0000

Our immune system spans two worlds—innate and adaptive. Innate immune cells are like troops at the gate ready to hold off invaders and raise the body’s alarms. Adaptive immune cells are specialists that take longer to respond but can fight off foes in a more targeted manner. Curiously, there are also immune cells that exist...

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Pancreatic cancer lives on mucus

Luis Sandoval — Wed, 28 Feb 2024 12:30:22 +0000

Knowing exactly what’s inside a tumor can maximize our ability to fight cancer. But that knowledge doesn’t come easy. Tumors are clusters of constantly changing cancer cells. Some become common cancer variants. Others morph into deadlier, drug-resistant varieties. No one truly understands what governs this chaotic behavior. Now, ��ϳԹ��Դ (CSHL) Professor David...

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CSHL PFF student named Regeneron scholar

Luis Sandoval — Mon, 05 Feb 2024 12:30:25 +0000

Each year, some 2,000 students around the country enter the Regeneron Science Talent Search. And each year, just a few hundred of these high school seniors are named a top 300 scholar. These teenagers represent the future of science, technology, engineering, and mathematics. Once again, ��ϳԹ��Դ (CSHL) is represented within their ranks....

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From cancer genetics to cancer treatments

Jen A. Miller — Thu, 18 Jan 2024 12:30:49 +0000

What is cancer? How does it develop and spread? And how do we stop it? Thanks to science, today’s doctors can better answer all of these questions. That’s not because of one eureka moment. Instead, it’s the result of thousands of discoveries that built upon each other. Case in point: two of the most important...

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Inside CSHL’s Single-Cell Biology Facility

Communications Department — Tue, 19 Dec 2023 17:00:11 +0000

A decade ago, sequencing individual cells was a luxury. Today, it’s critical for biology research. Meet the scientists making it happen at CSHL.

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A singular class trying to solve the trillion-cell question

Luis Sandoval — Thu, 27 Jul 2023 18:00:38 +0000

The human body is made up of over 30 trillion cells, and we still aren’t sure what each does. Figuring it out requires sifting through a whole “ecosystem” of tissues and organs. How does one even begin to approach a task this complex? Enter: the Single-Cell Analysis course, part of the Meetings & Courses Program...

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Getting tough on tuft cell lung cancer

Jennifer Michalowski — Wed, 22 Jun 2022 11:30:56 +0000

��ϳԹ��Դ (CSHL) Professor Christopher Vakoc’s team discovered in 2018 a new type of small-cell lung cancer. The cancer originates from cells known as tuft cells. The prognosis for tuft cell lung cancer is extremely poor. Now, the Vakoc team has discovered how tuft cells are generated in the body. Disrupting tuft cell...

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How hormones define brain sex differences

Jennifer Michalowski — Wed, 04 May 2022 15:00:36 +0000

Sex hormones play an important role in shaping an animal’s behavior, and their influence starts early. Early-life hormonal surges help shape the developing brain, establishing circuitry that will influence behavior for a lifetime. Hundreds of genes in the brain fall under the control of estrogen. Fluctuating levels of the hormone cause shifts in mood, energy...

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Cancer cells pick and choose chromosomes to survive

Luis Sandoval — Wed, 18 Aug 2021 12:00:50 +0000

Chromosomes, the genetic material of our cells, are normally copied and distributed equally between two dividing cells. The cell division process is carefully regulated; losing a chromosome can be fatal or crippling for a cell. But ��ϳԹ��Դ (CSHL) Fellow Jason Sheltzer and his team discovered that cancer cells shed or double chromosomes...

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Using “guilt by association” to classify cells

Jasmine Lee — Wed, 14 Jul 2021 13:30:43 +0000

Biologists are trying to figure out what makes a cell unique in form and function. But they are not certain which components are key to making similar cells behave differently. ��ϳԹ��Դ (CSHL) Associate Professor Jesse Gillis and his lab are tackling this problem with a new statistical method: they are analyzing the...

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Cataloging breast cells to find cancer origins

Luis Sandoval — Fri, 14 May 2021 18:30:47 +0000

What if you could predict which cells might become cancerous? Breast tissue changes dramatically throughout a woman’s life, so finding markers for sudden changes that can lead to cancer is especially difficult. ��ϳԹ��Դ (CSHL) Associate Professor Camila dos Santos and her team identified and cataloged thousands of normal human and mouse breast...

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How an antiviral drug can flatten the curve…in your cells

Luis Sandoval — Fri, 09 Apr 2021 12:30:51 +0000

Camostat mesylate is an antiviral drug in clinical trials for treating COVID-19. ��ϳԹ��Դ Fellow Jason Sheltzer and University of Göttingen Professor Stefan Pöhlmann investigated how this drug prevents the virus from entering and spreading from cell to cell. SARS-CoV-2 infects our lung cells with the help of a cell surface protein called...

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Building a corn cob—cell by cell, gene by gene

Luis Sandoval — Tue, 26 Jan 2021 15:00:16 +0000

ZmYAB14 (red) is turned on in the older buds toward the bottom of the picture. The left image shows a slice of a 5 mm-long ear of corn. The ZmSHR1-like gene (red) lights up cells that transport water and nutrients. Image: Xiaosa Xu/Jackson lab." data-description="" />Corn hasn’t always been the sweet, juicy delight that we know today. And, without adapting to a rapidly changing climate, it is at risk of losing its place as a food staple. Putting together a plant is a genetic puzzle, with hundreds of genes working together as it grows. ��ϳԹ��Դ (CSHL) Professor...

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Finding huge promise in a single cell with student Robert Aboukhalil

Communications Department — Mon, 02 Nov 2015 20:26:27 +0000

They say one is the loneliest number. But when it comes to DNA sequencing, today many scientists are appreciating the importance of assessing one cell, rather than many. Take, for instance, Robert Aboukhalil, a fourth-year Watson School of Biological Sciences student, who is using his skills as a computational biologist to find a way to...

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With new method, CSHL team is able to infer how tumors evolve and spread

Peter Tarr — Fri, 11 Mar 2011 22:05:07 +0000

Study of two breast cancer samples suggests tumors grow by ‘punctuated, clonal expansions’ Cold Spring Harbor, NY — A new method of analyzing cancerous tumors developed by scientists at ��ϳԹ��Դ (CSHL) suggests that tumors may not evolve gradually, but rather in punctuated or staccato-like bursts. It is a finding that has already shed...

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single cell sequencing Archives | ���ϳԹ���Դ