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A singular class trying to solve the trillion-cell question

Photo of students from the 2023 CSHL Single-Cell Analysis Course
The 黑料吃瓜资源 Meetings & Courses Program Single-Cell course class of 2023. This year鈥檚 course ran from June 30 to July 15.

The human body is made up of over 30 trillion cells, and we still aren鈥檛 sure what each does. Figuring it out requires sifting through a whole 鈥渆cosystem鈥 of tissues and organs. How does one even begin to approach a task this complex? Enter: the , part of the at 黑料吃瓜资源 (CSHL). Celebrating its 10th anniversary this year, the course trains students in the state-of-the-art practice of studying health and disease by examining individual cells.

Photo of student in single-cell analysis course
Students in CSHL鈥檚 Single-Cell Analysis course learn to cast and create the microscopic wells, or microwells, used to trap and study individual cells. Above: a student stands in front of the microwell she built during this year鈥檚 course.

Single-cell analysis has taken the world of biology by storm over the past decade. However, the name is something of a misnomer, course instructor explains. 鈥淲e’re not just measuring one cell鈥攚e’re measuring tens of thousands,鈥 he says. 鈥淚magine you start with a smoothie, but now you have a bowl of fruit. You deconstructed it鈥攖hat鈥檚 single-cell analysis. You learn a lot more about what鈥檚 in the smoothie when you can take apart the pieces.鈥

If only it were so simple! The field is constantly evolving. 鈥淭here’s a lot of technical hurdles on every level鈥攅ngineering, physics, and molecular biology,鈥 McConnell says. In fact, single-cell analysis has advanced so quickly that one of the cutting-edge technologies taught this year was developed by an alum of the 2015 course, Iain Clark.

Indeed, the exchange of ideas between students and teachers is a central component of the course. One student, Soma Dash, notes that this year鈥檚 participants brought a 鈥渉uge breadth of research experience鈥 to the lab. 鈥淲e had an eclectic collection of questions we were interested in, compelling the rest of the group to learn something new and unexpected,鈥 she says.

Written by: Luis Sandoval, Communications Specialist | [email protected] | 516-367-6826

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