molecular biology Archives | ��ϳԹ��Դ

A secret weapon against superbugs

Gina Dipietro — Tue, 21 Jul 2026 16:00:11 +0000

Staphylococcus aureus (MRSA) bacteria, shown here. The bacteria cause staph infections, which can spread rapidly in hospitals and nursing homes, often with deadly results. Image: © Maxim - stock.adobe.com" data-description="Colorful microscope image showing orange, yellow, and white spheres among pink and yellow fibrous strands." />Antibiotic resistance has quietly become one of the greatest threats to global healthcare. Each year, drug-resistant bacteria claim lives by rendering once-reliable antibiotics ineffective, turning routine surgeries, cancer treatments, and even common infections into potentially life-threatening events. Scientists around the world are racing to find new ways to stay ahead of these evolving pathogens. The...

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SBS awards honorary degree to James H. Eberwine

Communications Department — Thu, 07 May 2026 11:30:26 +0000

The ��ϳԹ��Դ (CSHL) School of Biological Sciences has awarded an honorary Doctor of Science degree to molecular neuroscientist James H. Eberwine, Ph.D. Eberwine is a professor of systems pharmacology and translational therapeutics at the University of Pennsylvania, where he also serves as co-director of the Penn Program in Single Cell Biology and...

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In remembrance of Professor Greg Hannon

Communications Department — Fri, 10 Apr 2026 18:00:42 +0000

It is with deep sadness we share news of the passing of our friend and former colleague Greg Hannon. A renowned molecular cancer biologist, Greg had an impact and influence on the scientific community that cannot be overstated. As his colleagues at Cancer Research UK Cambridge (CRUK) Institute stated, he “was a singular force of...

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A Closer Look: CSHL’s Microscopy Core

Communications Department — Mon, 30 Mar 2026 11:30:28 +0000

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Short-circuiting pancreatic cancer

Nick Wurm — Thu, 08 Jan 2026 16:00:45 +0000

Pancreatic ductal adenocarcinoma (PDAC) is the most lethal form of pancreas cancer. It’s also the most common form of the disease. Potential treatments typically target a key mutated oncogene called KRAS. In some cases, PDAC tumors with these mutations have resisted therapeutic efforts. However, combination therapies involving alternative drug targets may one day help clinicians...

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New mass spec innovation could transform research

Nick Wurm — Tue, 06 Jan 2026 17:00:39 +0000

Weight says a lot. In the kitchen, it could mean cooking with too little or too much of an ingredient. For scientists, a molecule’s weight can help determine its makeup. This, in turn, can shed light on whether a potential drug is acting on the body or not working at all. Weight can even reveal...

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Breast cancer case study could inform clinical trials

Jen A. Miller — Mon, 10 Nov 2025 12:30:14 +0000

MALAT1 (pink) than the surrounding tissues." data-description="Fluorescent microscopy image showing clusters of blue and purple cells on a black background." />When researchers look for potential cancer therapy targets, they typically go after protein-coding genes that participate in disease progression. Disrupt them and negate whatever role they play in cancer’s development or spread. Researchers at ��ϳԹ��Դ (CSHL) have also been working on another kind of target. They’re studying a long non-coding RNA called...

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Pediatric cancers: Rare, relentless, and real

Phil Renna — Wed, 05 Nov 2025 12:30:50 +0000

Pediatric cancer—two words that carry immense weight. For many, it’s a distant fear; for some, it’s a daily reality. And for my family, it became a devastating truth. After losing our teenage daughter to a rare form of cancer, we were left with a haunting question: Why are these cancers so difficult to treat? In...

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Dicer: Life’s ancient repair tool

Nick Wurm — Tue, 28 Oct 2025 15:00:47 +0000

Could yeast and humans be any more different? Going by looks alone, probably not. But peering into our genomes reveals surprising similarities. That’s because we share a common ancestor called LECA (last eukaryotic common ancestor). Before this single-celled organism died off around 2 billion years ago, it passed down Dicer, a key protein humans and...

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Special edition: Breast Cancer Awareness Month

Communications Department — Thu, 23 Oct 2025 11:30:49 +0000

Today, the five-year survival rate for early-stage breast cancer is about 99%. Awareness drives detection. But what about those breast cancers that aren’t caught early? What about those that evade common therapies? For Breast Cancer Awareness Month, we sat down with CSHL Professor David Spector to discuss some of his lab’s latest research and the...

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Why does cancer keep growing?

Jen A. Miller — Fri, 10 Oct 2025 11:30:24 +0000

Why do cancer cells keep dividing over and over? The answer can be found in fundamental biology breakthroughs of the late 20th century. In 1982, ��ϳԹ��Դ (CSHL) geneticist Michael Wigler helped identify the first known human oncogenes. When mutated, these genes produce an excess of proteins that cause uncontrolled cell growth. Soon...

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CSHL mourns the loss of David Baltimore

Nick Wurm — Fri, 12 Sep 2025 11:30:55 +0000

��ϳԹ��Դ (CSHL) mourns the passing of Nobel laureate and revolutionary molecular biologist David Baltimore. In 1959, Baltimore became the first member of CSHL’s newly launched Undergraduate Research Program (URP). That summer, he worked with then-Assistant CSHL Director Arthur Chovnick on a project studying the “Physiological genetics of Drosophila and Neurospora.” But it...

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��ϳԹ��Դ hope to thousands of families

Jen A. Miller — Tue, 05 Aug 2025 11:30:41 +0000

It’s a parent’s worst nightmare, finding out your newborn child may never walk or even stand on their own. That used to be the reality for as many as one in 6,000 babies born with spinal muscular atrophy (SMA), a genetic disorder that causes extreme nerve damage, muscle weakness, and sometimes, paralysis. For a long...

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Licensed to live

Jennifer Michalowski — Tue, 29 Jul 2025 11:30:21 +0000

The DNA packed inside every human cell contains instructions for life, written in billions of letters of genetic code. Every time a cell divides, the complete code, divided among 46 chromosomes, must be faithfully copied. This staggering task happens over and over with extraordinary precision. Decades of research have revealed how dozens of proteins work...

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Adrian Krainer wins 2025 Heinrich Wieland Prize

Nick Wurm — Wed, 16 Jul 2025 12:30:07 +0000

��ϳԹ��Դ Professor Adrian Krainer has won the 2025 Heinrich Wieland Prize. Awarded annually by the Boehringer Ingelheim Foundation, the €250,000 prize recognizes exceptional scientists whose pioneering research pushes the boundaries of knowledge in biochemistry, biology, chemistry, and physiology. Krainer received the award for his revolutionary RNA splicing research, which led to the...

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A new “link” to triple-negative breast cancer

Margaret Osborne — Mon, 30 Jun 2025 14:00:38 +0000

LINC01235 is seen in red." data-description="" />Breast cancer is one of the most common cancers among women in the United States. Thanks to decades of fundamental research, it’s also one of the most curable. The exception is a particularly aggressive variant known as triple-negative breast cancer (TNBC). It accounts for 10 to 15 percent of all breast cancer cases. It disproportionately...

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Cocktails & Chromosomes: Heresy in genetics

Communications Department — Tue, 17 Jun 2025 11:30:54 +0000

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Exposomics: Holistic health without the snake oil

Samuel Diamond — Thu, 12 Jun 2025 11:30:27 +0000

We live in the age of -omics. We have genomics to study complete sets of DNA. We have proteomics focused on all the proteins within our cells. And we have metabolomics for metabolites like sugars and lipids. Despite their massive reach and intense focus, these fields have blind spots. They’re both in the margins and...

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President’s essay: We are science, and science is crucial

Communications Department — Mon, 02 Jun 2025 12:53:01 +0000

At ��ϳԹ��Դ (CSHL), we deeply value our uniquely vibrant campus and culture. But we thrive because we are intensely engaged with the broad community of scientists across the United States and the world. By collaborating, educating, and sharing knowledge, we amplify our impact, enabling groundbreaking discovery at CSHL and beyond. This is...

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How does cancer spread? Follow the map

Jen A. Miller — Wed, 25 Sep 2024 11:30:07 +0000

Metastatic cancer can be a devastating diagnosis. The cancer is spreading. It may travel to multiple organs in the body. This could mean more pain and ultimately, death. Unfortunately, just how cancer spreads remains unclear. But now, ��ϳԹ��Դ (CSHL) Professor Adam Siepel and colleagues have a way to better understand that process....

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molecular biology Archives | ���ϳԹ���Դ