gene regulation and inheritance Archives | ��ϳԹ��Դ

Secrets of evolution found in ancient plant DNA

Samuel Diamond — Thu, 12 Mar 2026 18:00:13 +0000

You’ve heard of deep space, but what about deep time? Today’s geneticists and evolutionary biologists can extend their investigations further back in time than ever imagined. Still, many mysteries remain. One has vexed biologists for decades. In both plants and animals, gene sequences and functions are often conserved across species over hundreds of millions of...

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A journey into animal aging

Communications Department — Wed, 17 Sep 2025 13:48:55 +0000

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Cocktails & Chromosomes: Heresy in genetics

Communications Department — Tue, 17 Jun 2025 11:30:54 +0000

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At the Lab: The human Microprocessor

Communications Department — Tue, 27 May 2025 11:30:11 +0000

In biology, the phrase “molecular machinery” gets tossed around pretty regularly. But this week At the Lab, we’re talking about a particular molecular machine that truly earns the title. Join CSHL Professor & HHMI Investigator Leemor Joshua-Tor as she breaks down the crucial functions of Microprocessor.

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Big clues emerge in small RNA mystery

Jen A. Miller — Mon, 16 Dec 2024 12:30:00 +0000

Arabidopsis plant (as seen above) is loaded with a molecule called pseudouridine." data-description="" />AI generated voice with Rob Martienssen’s actual voice Not everything inside us is, strictly speaking, us. The closer we look at the genome, the more we appreciate the role of small RNAs in what we call epigenetic inheritance. That’s when traits get passed down without altering our basic DNA sequence. We now know that small...

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At the Lab Episode 24: Putting the brakes on brain cancer

Communications Department — Tue, 17 Sep 2024 11:30:13 +0000

If you’ve heard of glioblastoma, you might’ve heard of it in reference to some of the lives this brain cancer has claimed. Beau Biden’s is one of several high-profile deaths in recent decades. CSHL Professor Alea Mills has spoken to ABC Eyewitness News about the deadly disease. Now, she brings us deeper inside her team’s...

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At the Lab Episode 22: Outmuscling cancer

Communications Department — Tue, 03 Sep 2024 11:30:30 +0000

In 2014, experts from across the country came together at CSHL’s Banbury Center to discuss rhabdomyosarcoma (RMS), a tissue cancer mainly diagnosed in children. Now, CSHL Professor Christopher Vakoc could be at a turning point. You may have seen Vakoc on FOX. This week At the Lab, he brings us an RMS breakthrough 10 years...

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At the Lab Episode 10: The time of our lives

Communications Department — Tue, 04 Jun 2024 11:30:40 +0000

“You wouldn’t start making the fingernails on an arm until you had started to make the arm.” Sorry for the visual, but that quote, from CSHL Professor Christopher Hammell, really gets to the heart of this week’s podcast. Hear more from Hammell and an unlikely supporting cast as we delve into the timing of biological...

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From plant genomics to a bioscience revolution

Jen A. Miller — Mon, 25 Mar 2024 11:30:22 +0000

Arabidopsis thaliana, rice, and corn. But these breakthroughs aren’t just about plants. They’ve changed the way scientists think about all life on Earth. AI-generated image: © LadyAI - stock.adobe.com" data-description="" />Farmers have been playing with plant genomics since before the world knew what genes were. Does one strawberry plant produce sweeter fruits? Encourage its growth over less tasty crops. Voilà! Your strawberry crop is now yummier than ever. Since the turn of the 21st century, ��ϳԹ��Դ (CSHL) breakthroughs have helped revolutionize the...

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CSHL celebrates 50th anniversary of McClintock Laboratory

Nick Wurm — Mon, 20 Nov 2023 17:00:06 +0000

Barbara McClintock’s career at ��ϳԹ��Դ (CSHL) revolutionized genetics research. At CSHL’s “Animal House,” her groundbreaking experiments with corn led to the discovery of transposons, or “jumping genes” in 1944. Fifty years ago, at its 1973 Symposium, CSHL renamed the building in McClintock’s honor. Ten years later, in 1983, Barbara McClintock became the...

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First look: Whole-body gene expression

Communications Department — Mon, 06 Nov 2023 12:30:20 +0000

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These worms have rhythm

Nick Wurm — Tue, 05 Sep 2023 11:30:18 +0000

C. elegans worm, seen here, Professor Christopher Hammell’s team at the CSHL Cancer Center expanded upon an imaging technique originally developed for use in single cells. This allowed them to witness, for the first time, active gene expression taking place inside an animal." data-description="" />There’s a rhythm to developing life. Growing from a tiny cell cluster into an adult organism takes precise timing and control. The right genes must turn on at the right time, for the right duration, and in the correct order. Losing the rhythm can lead to diseases like cancer. So, what keeps every gene on...

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The ancient viruses in human DNA

Communications Department — Thu, 24 Aug 2023 11:30:28 +0000

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Where did our DNA come from?

Nick Wurm — Tue, 22 Aug 2023 11:30:21 +0000

About half of the human genome isn’t quite human. It’s made up of transposable elements (TEs)—descendants of ancient viruses. As a Ph.D. student at the Max-Delbrück Center for Molecular Medicine, Andrea Schorn studied an ancient TE that was resurrected from fish and is active in pretty much all vertebrates—except fish. Today, Schorn is an assistant...

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Blending history and science

Nick Wurm — Thu, 17 Aug 2023 11:30:51 +0000

In 1952, ��ϳԹ��Դ (CSHL) was the site for one of the most famous experiments in the history of biology. At the Animal House—later renamed in honor of Nobel laureate Barbara McClintock—Alfred Hershey and Martha Chase were working with viruses called bacteriophages. The pair sought to confirm whether genes were made of DNA...

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Cracking the mystery behind a deadly brain cancer

Luis Sandoval — Wed, 21 Dec 2022 16:00:21 +0000

The brain cancer, glioblastoma, is a fierce and formidable opponent. Its millions of victims include Senator John McCain, President Biden’s son, Beau, and famed film critic Gene Siskel, to name just a few. Most patients succumb within two years and few make it past five, a statistic that hasn’t improved in decades due to lack...

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Cancer lab makes surprise discoveries in heart disease

Margaret Osborne — Wed, 30 Nov 2022 12:30:45 +0000

Sometimes science can lead to unexpected discoveries in unexpected places. That’s what ��ϳԹ��Դ (CSHL) Professor David Spector experienced this year. For nearly four decades, Spector has been researching cancer—the United States’ second-leading cause of death. But this year, he found himself studying the first—heart disease. Spector’s research at CSHL focuses on how...

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Decoding how a protein on the move keeps cells healthy

Nick Wurm — Tue, 31 May 2022 12:00:07 +0000

Cells produce proteins like little factories. But if they make too much at the wrong times it can lead to diseases like cancer, so they control production with a process called RNA interference (RNAi). As of July 2021, several drugs already take advantage of RNAi to treat painful kidney and liver diseases—with another seven in...

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Paving a path to triple-negative breast cancer treatment

Daniel Dunaief — Tue, 29 Mar 2022 12:00:24 +0000

It’s the cancer version of “mini me.” ��ϳԹ��Դ (CSHL) Professor David Spector, among others, has developed organoids, which are miniature, three-dimensional copies of cancers. Organoids can be derived from cancer or healthy cells. They allow scientists to study the basic biology of particular types of tumors, then to test specific drugs on...

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Daniela Conte Foundation donates $30K for sarcoma research

Communications Department — Thu, 20 May 2021 15:00:10 +0000

On May 14, 2021, Katia Conte, executive director and president of the Daniela Conte Foundation (DCF), and board member Lisa Amatulli presented ��ϳԹ��Դ (CSHL) Professor Chris Vakoc with a check for $30,000 to support his lab’s cutting-edge research on rhabdomyosarcoma. The Vakoc laboratory studies how transcription factors, chromatin proteins, and signaling molecules...

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gene regulation and inheritance Archives | ���ϳԹ���Դ