epigenetics Archives | ��ϳԹ��Դ

Shapeshifting cancers’ masters, unmasked

Jen A. Miller — Mon, 24 Nov 2025 12:30:01 +0000

Some tumors are almost impossible to treat. That’s especially true for carcinomas, which don’t behave like other malignancies. Some of these tumors act as shapeshifters and start to resemble cells from other organs of the human body, such as skin. This bizarre behavior presents a challenge for existing therapies. “The tumors are notoriously plastic in...

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Pediatric cancers: Rare, relentless, and real

Phil Renna — Wed, 05 Nov 2025 12:30:50 +0000

Pediatric cancer—two words that carry immense weight. For many, it’s a distant fear; for some, it’s a daily reality. And for my family, it became a devastating truth. After losing our teenage daughter to a rare form of cancer, we were left with a haunting question: Why are these cancers so difficult to treat? In...

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Plate Race 2025

Communications Department — Mon, 25 Aug 2025 11:30:26 +0000

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A new fix for brain cancer?

Communications Department — Thu, 14 Aug 2025 11:30:26 +0000

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Exposomics: Holistic health without the snake oil

Samuel Diamond — Thu, 12 Jun 2025 11:30:27 +0000

We live in the age of -omics. We have genomics to study complete sets of DNA. We have proteomics focused on all the proteins within our cells. And we have metabolomics for metabolites like sugars and lipids. Despite their massive reach and intense focus, these fields have blind spots. They’re both in the margins and...

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Lessons learned in time: CSHL’s Symposium on aging

Communications Department — Wed, 11 Jun 2025 11:30:58 +0000

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Cocktails & Chromosomes: Cancer’s identity crisis

Communications Department — Thu, 19 Dec 2024 12:30:14 +0000

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Big clues emerge in small RNA mystery

Jen A. Miller — Mon, 16 Dec 2024 12:30:00 +0000

Arabidopsis plant (as seen above) is loaded with a molecule called pseudouridine." data-description="" />AI generated voice with Rob Martienssen’s actual voice Not everything inside us is, strictly speaking, us. The closer we look at the genome, the more we appreciate the role of small RNAs in what we call epigenetic inheritance. That’s when traits get passed down without altering our basic DNA sequence. We now know that small...

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Plants have a backup plan

Nick Wurm — Thu, 03 Oct 2024 11:30:08 +0000

Arabidopsis, seen here, have two options to ensure accurate chromosome division—a molecule called DDM1 and a process known as RNAi. If Arabidopsis loses one of these, it’s fine. But if it loses both, it’s in trouble." data-description="" />Tending a garden is hard work. Imagine it from the plants’ perspective. Each relies on fine-tuned genetic processes to pass down accurate copies of chromosomes to future generations. These processes sometimes involve billions of moving parts. Even the tiniest disruption can have a cascading effect. So, for plants like Arabidopsis thaliana, it’s good to have...

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At the Lab Episode 25: How maize became corn

Communications Department — Tue, 24 Sep 2024 11:30:36 +0000

The journey from maize to corn isn’t just about going from farm to table. It starts with an evolutionary event that has puzzled plant biologists for decades. This week At the Lab, CSHL Professor, HHMI Investigator, and Genetics Society Medal recipient Rob Martienssen unravels a 4,000-year-old mystery in just over three minutes.

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At the Lab Episode 24: Putting the brakes on brain cancer

Communications Department — Tue, 17 Sep 2024 11:30:13 +0000

If you’ve heard of glioblastoma, you might’ve heard of it in reference to some of the lives this brain cancer has claimed. Beau Biden’s is one of several high-profile deaths in recent decades. CSHL Professor Alea Mills has spoken to ABC Eyewitness News about the deadly disease. Now, she brings us deeper inside her team’s...

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At the Lab Episode 19: Brain sex

Communications Department — Tue, 13 Aug 2024 11:30:15 +0000

Depending on where your head’s at, the phrase “brain sex” might not mean what you think. On the other hand, this week’s podcast is all about hormones. In our latest edition of At the Lab, we hear from CSHL Associate Professor Jessica Tollkuhn about the role of estrogen in brain development.

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Corn’s ‘missing link’

Margaret Osborne — Wed, 07 Aug 2024 15:00:25 +0000

Teosinte Pollen Drive (TPD) is a selfish genetic system in maize-teosinte hybrids, which allows only pollen with both toxin and antidote to survive. Here, we see the pollen-producing part of the maize-teosinte hybrid. Image: Jon Cahn/Martienssen lab" data-description="" />��ϳԹ��Դ (CSHL) has begun to unravel a mystery millennia in the making. Our story begins 9,000 years ago. It was then that maize was first domesticated in the Mexican lowlands. Some 5,000 years later, the crop crossed with a species from the Mexican highlands called teosinte mexicana. This resulted in cold adaptability....

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Rob Martienssen awarded 2024 Genetics Society Medal

Nick Wurm — Wed, 08 Nov 2023 18:30:29 +0000

On November 8, the Genetics Society awarded ��ϳԹ��Դ (CSHL) Professor Rob Martienssen the 2024 Genetics Society Medal. Martienssen earned the award for his outstanding research in the field of genetics. Martienssen is a leading figure in the world of epigenetics. He played a key role in global efforts to produce the first...

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The dance of epigenetic inheritance

Communications Department — Wed, 27 Sep 2023 11:30:43 +0000

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How plants pass down genetic memories

Jennifer Michalowski — Mon, 28 Aug 2023 15:00:16 +0000

Arabidopsis thaliana is a plant species widely used to make fundamental biological discoveries. With the help of this versatile test subject, CSHL scientists have now dug up the secrets of a process that helps control inheritance." data-description="" />When organisms pass their genes on to future generations, they include more than the code spelled out in DNA. Some also pass along chemical markers that instruct cells how to use that code. The passage of these markers to future generations is known as epigenetic inheritance. It’s particularly common in plants. So, significant findings here...

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The ancient viruses in human DNA

Communications Department — Thu, 24 Aug 2023 11:30:28 +0000

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Jessica Tollkuhn wins $750K MIND Prize

Nick Wurm — Tue, 25 Apr 2023 14:00:36 +0000

��ϳԹ��Դ Associate Professor Jessica Tollkuhn has won the inaugural Maximizing Innovation in Neuroscience Discovery (MIND) Prize. The $750,000 award will support her research on how sex hormones affect the brain over the course of a lifetime. The Pershing Square Foundation’s MIND Prize honors early-to-mid-career investigators pursuing innovative research on neurodegenerative diseases. “I’m...

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Cracking the mystery behind a deadly brain cancer

Luis Sandoval — Wed, 21 Dec 2022 16:00:21 +0000

The brain cancer, glioblastoma, is a fierce and formidable opponent. Its millions of victims include Senator John McCain, President Biden’s son, Beau, and famed film critic Gene Siskel, to name just a few. Most patients succumb within two years and few make it past five, a statistic that hasn’t improved in decades due to lack...

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How hormones define brain sex differences

Jennifer Michalowski — Wed, 04 May 2022 15:00:36 +0000

Sex hormones play an important role in shaping an animal’s behavior, and their influence starts early. Early-life hormonal surges help shape the developing brain, establishing circuitry that will influence behavior for a lifetime. Hundreds of genes in the brain fall under the control of estrogen. Fluctuating levels of the hormone cause shifts in mood, energy...

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