黑料吃瓜资源

Cold Spring Harbor, NY — Most people have never tasted a groundcherry; the small, sweet relative of the tomato that plant biologist Zachary Lippman describes as 鈥渢ropically intoxicating.鈥� That鈥檚 because the groundcherry plant, with its long, straggly branches and sporadically ripening fruit, is unsuitable for large-scale agriculture. For now, the treat is reserved for people willing to wrangle the plant in their garden or those lucky enough to find it at a farmers鈥� market.

That could change, thanks to the genome-editing tool known as CRISPR. and 黑料吃瓜资源 (CSHL) Professor Lippman, heads a team with deep knowledge of tomato plants and the genes that control their growth. They used CRISPR to engineer groundcherries that maintain compact, manageable stems and that produce larger, more abundant fruit.

Lippman says the fruit, which develops inside a papery husk like a tomatillo, has a surprising flavor, echoing both tomato and pineapple. The plant that produces it is still wild: no effort has been made to make it a practical crop through traditional breeding practices.

Because the plant is closely related to the well-studied tomato, Lippman鈥檚 team had clues about which genes control the groundcherry鈥檚 growth and flowering. 鈥淲e knew of some clear targets to improve the plant鈥檚 architecture, fruit production, and fruit size,鈥� he says.

In the October 1, 2018 issue of Nature Plants, Lippman, collaborator Joyce Van Eck at the Boyce Thompson Institute, and colleagues report the effects of CRISPR-mediated changes to three groundcherry genes. One change reins in production of a hormone that regulates flowering; making plants more compact and producing fruit in clusters rather than one by one. A change to another flowering hormone leads to denser fruit production: plants with a CRISPR-generated mutation in this gene produced up to 50 percent more fruit along a given stem length than the unmodified plant, Lippman says. The third change boosts the number of seedy sections within each fruit, thereby increasing its overall size.

Lippman鈥檚 team is working on other aspects of the plant to make the groundcherry practical for large-scale production. The current success demonstrates that it鈥檚 possible. In less than two years, they achieved improvements that would have taken far longer using traditional breeding practices.

Lippman is enthusiastic about making groundcherries more widely available. But the implications are much broader. 鈥淭his is pretty good proof that with gene editing you can think about bringing other wild plants or orphan crops into agricultural production,鈥� he says. 鈥淭he more arrows we have in our quiver to address agricultural needs in the future, the better off we鈥檙e going to be.鈥�

Written by: Jennifer Michalowski, Science Writer | [email protected] | 516-367-8455

Funding

NSF Postdoctoral Research Fellowship in Biology; NSF Plant Genome Research Program

Citation

Z. Lemmon et al. ‘Rapid improvement of domestication traits in an orphan crop by genome editing’ was published on October 1, 2018, Nature Plants. DOI: