Twenty-nine scientists sat around tables bathed in the warm sunlight of a late summer morning in September 2016. The experts who met in the glass-walled conference room that looked out over the Banbury Center estate hailed from around the world; some had traveled from London, Geneva, Stockholm, and Wuhan, while others had commuted an extra 15 minutes from their offices at 黑料吃瓜资源. The conference program (PDF), tucked into laps, folders, and suit jackets, named the event, 鈥渢he Mammalian Brain Cell Diversity and Census鈥� meeting and listed a schedule packed with presentations and discussion sessions that spanned topics from cell diversity in the nervous system to tools for automated mapping of the brain. The attendees themselves represented a vast and varied collection of knowledge, ranging from chemical engineering to molecular neuroscience to computer science. For the duration of their closed meeting, these specialists discussed the possibility of mapping humanity鈥檚 next frontier: the brain.
Over the last five years, several of the participants who attended that meeting have since established the NIH-funded BRAIN Initiative Cell Census Network (BICCN) which completed its first major milestone paper in early October. BICCN is building a publicly available atlas of high-resolution images of different types of brain cells. Here, the Banbury Center looks back at the meeting that sparked the origins of the census project.
The new BICCN update includes a that map the cells of the mammalian primary motor cortex down to the molecular level. The data and the were published in Nature. Before any of that could become possible, though, the Cell Diversity and Census meeting first stimulated the conversation. The primary goal of the meeting was to, 鈥渄iscuss the potential to coordinate the production of broad reference cell catalogs for the vertebrate (mammalian) brain.鈥� The organizers of the meeting hoped that, with this knowledge, 鈥渘ovel genetic and non-genetic tools can be developed to accurately deliver genes, proteins, and chemicals to specific cells of interest in order to manipulate cells and circuits鈥n animals and, potentially, in humans.鈥� Understanding the system and each of its parts could help science develop ways to address neurodegeneration and neuropsychiatric disease.
At the time of the Cell Diversity and Census conference, the conference organizers wrote, 鈥淯sing novel tools and integrated approaches, scientists can profile molecular and cellular phenotypes like never before鈥︹�� Presenters discussed different types of data and ways that cells could be classified, including molecular profiling, morphology, connectivity, lineage mapping, and functional measures such as physiology and calcium imaging.
By the time conference attendees left on the final day, they had discussed and debated suggestions and recommendations and had begun to set up plans for how data could be shared openly, freely, and quickly with one another. Many of the attendees from the conference remain closely involved with the BICCN census today. Their work will continue to map out the path of neuroscience research for years to come.