W. Richard McCombie Archives | ��ϳԹ��Դ

Brescia Foundation supports ILFS-1 research at CSHL

Gina Dipietro — Tue, 10 Feb 2026 12:30:58 +0000

When Patricia and Jason Brescia welcomed their first child, Jason Michael Brescia Jr., in December 2022, they could not have imagined how quickly joy would turn to heartbreak. Born prematurely at 27 weeks, Jason Michael Jr. spent 54 days in intensive care before being diagnosed with Infantile Liver Failure Syndrome type 1 (ILFS-1), a rare...

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Cocktails & Chromosomes: Long-lived creatures of the night

Communications Department — Tue, 19 Nov 2024 12:30:08 +0000

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At the Lab Season 1 Research Rewind: AI+

Communications Department — Tue, 29 Oct 2024 11:30:55 +0000

How do we interpret what AI tells us without knowing the logic of its own interpretations? How do we make artificial intelligence more efficient and reliable without fully understanding biological intelligence’s efficiency and reliability problems? This season’s final Research Rewind brings us from the realm of quantitative biology to neuroscience, genomics, and beyond. You’ll hear...

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At the Lab Episode 16: Bats!

Communications Department — Tue, 23 Jul 2024 16:00:17 +0000

Sometimes one word says it all. Case in point: Bats. This week At the Lab, we hear from CSHL Professor W. Richard McCombie about the curious origin story behind a recent headline-making study his lab conducted with Professor Adam Siepel, postdoc Armin Scheben, and the American Museum of Natural History.

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From plant genomics to a bioscience revolution

Jen A. Miller — Mon, 25 Mar 2024 11:30:22 +0000

Arabidopsis thaliana, rice, and corn. But these breakthroughs aren’t just about plants. They’ve changed the way scientists think about all life on Earth. AI-generated image: © LadyAI - stock.adobe.com" data-description="" />Farmers have been playing with plant genomics since before the world knew what genes were. Does one strawberry plant produce sweeter fruits? Encourage its growth over less tasty crops. Voilà! Your strawberry crop is now yummier than ever. Since the turn of the 21st century, ��ϳԹ��Դ (CSHL) breakthroughs have helped revolutionize the...

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A quiz for the ages

Communications Department — Mon, 29 Jan 2024 12:30:33 +0000

{“questions”:{“4ib35”:{“id”:”4ib35″,”mediaType”:”image”,”answerType”:”text”,”imageCredit”:””,”image”:”https:\/\/www.cshl.edu\/wp-content\/uploads\/2023\/11\/Pancreatic_tissue_with_CAR_T_cells.jpg”,”imageId”:”67343″,”video”:””,”imagePlaceholder”:””,”imagePlaceholderId”:””,”title”:”Modified T cells may hold the key to the mythical fountain of youth. CSHL scientists discovered just one dose is enough to rejuvenate older mice. What happened to these mice after T cell treatment?”,”desc”:”Assistant Professor Corina Amor Vegas discovered T cells can be reprogrammed to fight aging. After using them to eliminate specific cells in...

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From cancer genetics to cancer treatments

Jen A. Miller — Thu, 18 Jan 2024 12:30:49 +0000

What is cancer? How does it develop and spread? And how do we stop it? Thanks to science, today’s doctors can better answer all of these questions. That’s not because of one eureka moment. Instead, it’s the result of thousands of discoveries that built upon each other. Case in point: two of the most important...

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Holy immunity! Bat genes key against COVID, cancer

Nick Wurm — Mon, 16 Oct 2023 11:30:39 +0000

Artibeus jamaicensis, the Jamaican fruit bat (seen here), and Pteronotus mesoamericanus, the Mesoamerican mustached bat." data-description="" />Bats have acquired remarkable traits throughout their evolution. They’re the only mammals that can fly, and they live much longer than other animals their size. But perhaps most impressive is their robust immune system. It protects bats from viruses that wreak havoc in humans, like COVID-19 or Ebola. It also keeps bats relatively cancer-free. How?...

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The evolution of autism research

Luis Sandoval — Thu, 25 May 2023 11:30:32 +0000

The scientific community’s views on autism spectrum disorder (ASD) have changed significantly over the last two decades. ��ϳԹ��Դ (CSHL) has played an important role in this evolution, as our scientists have uncovered several genetic factors underlying ASD. Of course, that evolution didn’t happen overnight. It is the result of progressive research that...

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CSHL professors on the cutting edge of scientific research

Nick Wurm — Mon, 21 Nov 2022 13:30:48 +0000

��ϳԹ��Դ (CSHL) scientists produced some of 2022’s most popular research. CSHL Professors W. Richard McCombie, David Tuveson, and Christopher Vakoc, and Adjunct Professor Z. Josh Huang rank among the top 1% of the world’s most cited researchers, according to global analytics firm Clarivate. Clarivate’s Highly Cited Researchers List recognizes researchers with broad...

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President’s essay: Foundations for the future

Communications Department — Wed, 25 May 2022 11:30:35 +0000

This essay highlights the diverse programs of ��ϳԹ��Դ (CSHL), revealing how seemingly separate initiatives strategically intertwine to make this institution central to the future of science. I believe that the interconnectivity of our research and education programs is CSHL’s greatest strength. Combined, they enhance the impact of science conducted on our Long...

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New genetic research to understand racial disparity in cancers

Dagnia Zeidlickis — Tue, 08 Sep 2020 21:00:34 +0000

Clinicians and scientists at ��ϳԹ��Դ (CSHL) will lead three new projects championed by the New York Genome Center (NYGC) to investigate the genetic contributions of ethnicity to the increased incidence of colon, endometrial, and pancreas cancers in African Americans. CSHL’s Cancer Center investigators will collaborate with Northwell Health Cancer Institute (Northwell) and...

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CSHL investigators rank among world’s most highly cited

Brian Stallard — Wed, 11 Dec 2019 14:00:14 +0000

Seven researchers affiliated with ��ϳԹ��Դ (CSHL) have been named among the scientists producing the top 1 percent of the most highly cited research in the world. They join CSHL Professor Michael Wigler, who is listed as one of the most extensively cited researchers of all time. The annual Highly Cited Researchers list...

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An essay from the President: Biology for the planet

Communications Department — Thu, 16 May 2019 16:17:34 +0000

As we advance toward the middle of the twenty-first century, humanity faces an existential challenge: figuring out how to feed the world’s rapidly growing population in the face of climate change and the increasingly limited availability of key nutrients and suitable land for farming. We need solutions that are local, national and global to increase...

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Base Pairs Episode 17: Genomes, justice, and the journey here

Sara Roncero-Menendez — Sat, 15 Sep 2018 15:04:47 +0000

Base Pairs podcast - A look at how gene-mapping works, what scientists can tell by looking at your genome, and what it means for your privacy.

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Genomes, justice, and the journey here

Sara Roncero-Menendez — Sat, 15 Sep 2018 14:30:07 +0000

Base Pairs podcast Mail-order genetic testing—more accurately known as genotyping—has become a growing trend. Simply spit into a tube, and companies claim they can tell you about where your family comes from, what conditions and illnesses you might be predisposed to, and what your family tree looks like. One of the more surprising uses of...

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Massive genome havoc in breast cancer is revealed

Peter Tarr — Fri, 13 Jul 2018 01:20:22 +0000

Cold Spring Harbor, NY — In cancer cells, genetic errors wreak havoc. Misspelled genes, as well as structural variations—larger-scale rearrangements of DNA that can encompass large chunks of chromosomes—disturb carefully balanced mechanisms that have evolved to regulate cell growth. Genes that are normally silent are massively activated and mutant proteins are formed. These and other...

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Portrait of a Neuroscience Powerhouse

Peter Tarr — Fri, 27 Apr 2018 16:07:30 +0000

At noon every Tuesday from September through June, scenes from a revolution in neuroscience are playing out at ��ϳԹ��Դ. Week after week, over 100 scientists cram themselves into a ground-floor meeting room in the Beckman Laboratory. It’s standing-room only as everyone in the Neuroscience Program settles in to hear details of the...

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New study casts sharpest light yet on genetic mysteries of autism

Peter Tarr — Wed, 29 Oct 2014 14:00:32 +0000

Our picture of how genetic errors contribute to autism has just gotten sharper. Cold Spring Harbor, NY — Our picture of how genetic errors contribute to autism has just gotten sharper. The latest series of clarifications in what, in its totality, is a very complex puzzle, emerges from new research published in Nature today by...

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Putting together the genome with first-year student Maria Nattestad

Communications Department — Thu, 22 May 2014 02:10:42 +0000

In 1990, the effort to sequence the human genome began, led, in part, by ��ϳԹ��Դ’s then-director Jim Watson. Scientists anticipated the project would reveal about 100,000 genes occupying the 3.3 billion bases of DNA. The human genome sequence would help us understand and treat thousands of diseases with genetic contributions. Sequencing cost between $2 and...

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W. Richard McCombie Archives | ���ϳԹ���Դ