RNA splicing Archives | ��ϳԹ��Դ

Short-circuiting pancreatic cancer

Nick Wurm — Thu, 08 Jan 2026 16:00:45 +0000

Pancreatic ductal adenocarcinoma (PDAC) is the most lethal form of pancreas cancer. It’s also the most common form of the disease. Potential treatments typically target a key mutated oncogene called KRAS. In some cases, PDAC tumors with these mutations have resisted therapeutic efforts. However, combination therapies involving alternative drug targets may one day help clinicians...

The post Short-circuiting pancreatic cancer appeared first on ��ϳԹ��Դ.

Can you ace this SMA quiz?

Communications Department — Thu, 07 Aug 2025 11:30:37 +0000

{“questions”:{“8r78v”:{“id”:”8r78v”,”mediaType”:”image”,”answerType”:”text”,”imageCredit”:””,”image”:”https:\/\/www.cshl.edu\/wp-content\/uploads\/2025\/07\/Richard_Roberts_Phillip_Sharp.jpg”,”imageId”:”74800″,”video”:””,”imagePlaceholder”:””,”imagePlaceholderId”:””,”title”:”In 1993, Richard Roberts and Phillip Sharp won the Nobel Prize in Physiology or Medicine for which revolutionary discovery?”,”desc”:”While CSHL played a role in all of these groundbreaking discoveries, only one is attributable to Roberts and Sharp. In 1977, CSHL\u2019s Richard Roberts and MIT\u2019s Phillip Sharp co-discovered split genes and RNA splicing while working with...

The post Can you ace this SMA quiz? appeared first on ��ϳԹ��Դ.

��ϳԹ��Դ hope to thousands of families

Jen A. Miller — Tue, 05 Aug 2025 11:30:41 +0000

It’s a parent’s worst nightmare, finding out your newborn child may never walk or even stand on their own. That used to be the reality for as many as one in 6,000 babies born with spinal muscular atrophy (SMA), a genetic disorder that causes extreme nerve damage, muscle weakness, and sometimes, paralysis. For a long...

The post ��ϳԹ��Դ hope to thousands of families appeared first on ��ϳԹ��Դ.

Adrian Krainer wins 2025 Heinrich Wieland Prize

Nick Wurm — Wed, 16 Jul 2025 12:30:07 +0000

��ϳԹ��Դ Professor Adrian Krainer has won the 2025 Heinrich Wieland Prize. Awarded annually by the Boehringer Ingelheim Foundation, the €250,000 prize recognizes exceptional scientists whose pioneering research pushes the boundaries of knowledge in biochemistry, biology, chemistry, and physiology. Krainer received the award for his revolutionary RNA splicing research, which led to the...

The post Adrian Krainer wins 2025 Heinrich Wieland Prize appeared first on ��ϳԹ��Դ.

The Adenovirus Gazebo

Nick Wurm — Thu, 26 Jun 2025 11:30:03 +0000

When the weather’s right, you can find any number of ��ϳԹ��Դ (CSHL) students, faculty, and staff around the gazebo on Bungtown Road. The spot’s popularity is undoubtedly owed to its excellent view of the harbor. But crowning the gazebo is an homage to something arguably just as important to CSHL as its...

The post The Adenovirus Gazebo appeared first on ��ϳԹ��Դ.

Cocktails & Chromosomes: Heresy in genetics

Communications Department — Tue, 17 Jun 2025 11:30:54 +0000

The post Cocktails & Chromosomes: Heresy in genetics appeared first on ��ϳԹ��Դ.

SBS awards honorary degree to accomplished biologist

Communications Department — Wed, 07 May 2025 16:00:23 +0000

The ��ϳԹ��Դ (CSHL) School of Biological Sciences has awarded an honorary Doctor of Science degree to molecular biologist James L. Manley, Ph.D. The biologist is recognized for his work in eukaryotic gene expression, particularly in the areas of transcription and RNA splicing. James L. Manley received a Bachelor of Science from Columbia...

The post SBS awards honorary degree to accomplished biologist appeared first on ��ϳԹ��Դ.

Nature is trying to tell you something

Jen A. Miller — Mon, 03 Feb 2025 12:30:52 +0000

“Nature is trying to tell you something.” Taken by itself, this quote from Nobel laureate and former ��ϳԹ��Դ (CSHL) scientist Richard Roberts suggests that the solutions to any number of problems may be within earshot. If only things were so simple. The fact is, scientific experiments go awry all the time. When...

The post Nature is trying to tell you something appeared first on ��ϳԹ��Դ.

Adrian Krainer wins Albany Prize for biomedical research

Luis Sandoval — Tue, 08 Oct 2024 15:00:21 +0000

��ϳԹ��Դ (CSHL) Professor Adrian Krainer has won the Albany Prize, one of America’s largest awards for biomedical research. He now joins a prestigious list of recipients that includes names like Anthony Fauci, Emmanuelle Charpentier, and Jennifer Doudna. The Albany Prize recognizes scientists whose work has translated from “the bench to the bedside.”...

The post Adrian Krainer wins Albany Prize for biomedical research appeared first on ��ϳԹ��Դ.

Katherine Alexander joins CSHL cancer faculty

Luis Sandoval — Mon, 05 Aug 2024 11:30:35 +0000

The nucleus is a central cellular compartment famous for housing DNA. But it also harbors a collection of lesser-known structures called nuclear speckles. “If the nucleus is a lake filled with DNA, the speckles are 30 to 50 islands intermingled inside that lake of different shapes, sizes, and textures,” says ��ϳԹ��Դ’s (CSHL’s)...

The post Katherine Alexander joins CSHL cancer faculty appeared first on ��ϳԹ��Դ.

RNA splicing’s spotters

Jennifer Michalowski — Mon, 10 Jun 2024 11:30:16 +0000

Bodybuilders and cellular mechanisms agree generating protein is a heavy lift. To complete the task, cells rely on complexes called spliceosomes. These molecular machines snip extra bits out of our genes’ RNA copies and piece together precise instructions for protein-building. When the splicing process goes awry, it can result in diseases like cancer or spinal...

The post RNA splicing’s spotters appeared first on ��ϳԹ��Դ.

President’s essay: The continuous cycle of discovery

Communications Department — Thu, 30 May 2024 11:30:43 +0000

��ϳԹ��Դ (CSHL) is a vibrant intellectual community that enables groundbreaking discovery. Our idyllic setting and state-of-the-art facilities offer a uniquely supportive environment for bioscience breakthroughs. However, CSHL’s community is not bound by the geography of our campus. Science worldwide has been strengthened by people who spend time on our campus and by...

The post President’s essay: The continuous cycle of discovery appeared first on ��ϳԹ��Դ.

Why some RNA drugs work better than others

Jennifer Michalowski — Wed, 06 Mar 2024 12:30:20 +0000

Spinal muscular atrophy, or SMA, is the leading genetic cause of infant death. Less than a decade ago, ��ϳԹ��Դ (CSHL) Professor Adrian Krainer showed this brutal disease can be treated by tweaking a process called RNA splicing. This breakthrough resulted in Spinraza, the first effective treatment for SMA. It also opened a...

The post Why some RNA drugs work better than others appeared first on ��ϳԹ��Դ.

Learn about the cool campus artwork at CSHL

Charlotte Hu — Mon, 15 May 2023 11:30:39 +0000

{“questions”:{“bknaf”:{“id”:”bknaf”,”mediaType”:”image”,”answerType”:”text”,”imageCredit”:””,”image”:”https:\/\/www.cshl.edu\/wp-content\/uploads\/2019\/11\/Waltz-of-the-Polypeptides-Mara-Haseltine.jpg”,”imageId”:”35268″,”video”:””,”imagePlaceholder”:””,”imagePlaceholderId”:””,”title”:”This sculpture by Mara G. Haseltine consists of oblong-shaped blobs strung together by a ribbon. What biological process is this supposed to depict?”,”desc”:”The statue, Waltz of the Polypeptides, depicts how a protein is created in cells. The oblong blobs are ribosomes, and the ribbon that runs through them is the protein. Ribosomes receive protein-making instructions...

The post Learn about the cool campus artwork at CSHL appeared first on ��ϳԹ��Դ.

This killer protein causes pancreatic cancer

Nick Wurm — Wed, 26 Apr 2023 14:00:26 +0000

Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer. It’s also one of the deadliest. More than 90% of PDAC patients die within five years of diagnosis. Usually, by the time the cancer is identified, it has already spread. “PDAC is often found too late for treatments like chemotherapy and surgery to...

The post This killer protein causes pancreatic cancer appeared first on ��ϳԹ��Դ.

Krainer named Society for RNA Therapeutics board member

Samuel Diamond — Tue, 18 Apr 2023 11:30:59 +0000

If RNA therapeutics were once considered the future of medicine, that future is now. Studies suggest RNA-based treatments have saved tens of millions of lives over the past few years. Now, the newly formed Society for RNA Therapeutics has come together to help further this cutting-edge science. On April 10, ��ϳԹ��Դ Professor...

The post Krainer named Society for RNA Therapeutics board member appeared first on ��ϳԹ��Դ.

From tragedy, a potential pediatric cancer treatment

Nick Wurm — Wed, 12 Apr 2023 18:00:35 +0000

Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brain cancer that often kills within a year of diagnosis. Surgery is almost impossible because of the tumors’ location. Chemotherapy has debilitating side effects. New treatment options are desperately needed. ��ϳԹ��Դ Professor Adrian Krainer is best known for his groundbreaking research on antisense...

The post From tragedy, a potential pediatric cancer treatment appeared first on ��ϳԹ��Դ.

A new treatment approach for cystic fibrosis

Luis Sandoval — Thu, 14 Jul 2022 20:00:17 +0000

Antisense oligonucleotides, or ASOs, are molecules that can be used to control protein levels in cells. ��ϳԹ��Դ Professor Adrian Krainer leveraged ASO technology to develop the first FDA-approved treatment for spinal muscular atrophy called Spinraza®. The drug has helped over 11,000 patients make more of a protein that certain neurons in the...

The post A new treatment approach for cystic fibrosis appeared first on ��ϳԹ��Դ.

Krainer awarded Watanabe Prize in Translational Research

Nick Wurm — Thu, 16 Jun 2022 19:30:54 +0000

The Indiana University (IU) School of Medicine awarded ��ϳԹ��Դ Professor Adrian Krainer the August M. Watanabe Prize in Translational Research for his revolutionary work on a cellular process called RNA splicing. Krainer’s research led to the development of nusinersen (Spinraza®), the first FDA-approved treatment for spinal muscular atrophy (SMA). SMA is a...

The post Krainer awarded Watanabe Prize in Translational Research appeared first on ��ϳԹ��Դ.

Cutting off liver cancer’s nutrient supply chain

Daniel Dunaief — Thu, 03 Feb 2022 12:30:11 +0000

The World Health Organization projects that starting in 2030, over a million people will die each year from liver cancer. ��ϳԹ��Դ (CSHL) Professor Adrian Krainer, former postdoc Wai Kit Ma, and Dillon Voss, a Stony Brook University M.D.-Ph.D. student-in-residence in Krainer’s lab, have come up with a way to interfere with the...

The post Cutting off liver cancer’s nutrient supply chain appeared first on ��ϳԹ��Դ.

RNA splicing Archives | ���ϳԹ���Դ