Nicholas Tonks Archives | ��ϳԹ��Դ

Researchers find new way to slow memory loss in Alzheimer’s

Gina Dipietro — Thu, 05 Feb 2026 12:30:28 +0000

Alzheimer’s disease is often measured in statistics: millions affected worldwide, cases rising sharply, costs climbing into the trillions. For families, the disease is experienced far more intimately. “It’s a slow bereavement,” says ��ϳԹ��Դ Professor Nicholas Tonks, whose mother lived with Alzheimer’s. “You lose the person piece by piece.” There’s a lot of...

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Women’s health quiz

Communications Department — Tue, 19 Mar 2024 11:30:35 +0000

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A quiz for the ages

Communications Department — Mon, 29 Jan 2024 12:30:33 +0000

{“questions”:{“4ib35”:{“id”:”4ib35″,”mediaType”:”image”,”answerType”:”text”,”imageCredit”:””,”image”:”https:\/\/www.cshl.edu\/wp-content\/uploads\/2023\/11\/Pancreatic_tissue_with_CAR_T_cells.jpg”,”imageId”:”67343″,”video”:””,”imagePlaceholder”:””,”imagePlaceholderId”:””,”title”:”Modified T cells may hold the key to the mythical fountain of youth. CSHL scientists discovered just one dose is enough to rejuvenate older mice. What happened to these mice after T cell treatment?”,”desc”:”Assistant Professor Corina Amor Vegas discovered T cells can be reprogrammed to fight aging. After using them to eliminate specific cells in...

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New antibody could target breast cancers

Jennifer Michalowski — Mon, 30 Oct 2023 11:30:29 +0000

An enzyme that may help some breast cancers spread can be stopped with an antibody created in the lab of ��ϳԹ��Դ Professor Nicholas Tonks. With further development, the antibody might offer an effective drug treatment for those same breast cancers. The new antibody targets an enzyme called PTPRD that is overabundant in...

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President’s essay: Bringing bold visions to life

Communications Department — Fri, 26 May 2023 11:30:08 +0000

The art of high-impact research, which is at the core of ��ϳԹ��Դ (CSHL), is to pursue important questions, follow unanticipated leads, and be bold in crafting new ideas. In this way, we challenge our researchers to move science into new frontiers. While our scientists have freedom to pursue their ideas, they are...

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Disarming the immune system’s lethal lung response

Communications Department — Fri, 23 Sep 2022 19:30:09 +0000

Neutrophils, the most abundant type of white blood cell, are the body’s first line of defense against infection. Foreign pathogens can stress the body and activate neutrophils. When activated, neutrophils employ various weapons to protect the body. But if overactivated, these weapons can damage the body’s own tissues. Lung tissue is saturated with blood vessels,...

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Copper, cancer, and COVID-19: The story of an idea, a meeting, and a paper

Hannah Stewart — Fri, 04 Mar 2022 17:00:27 +0000

Where does a scientific review article begin? How does an idea evolve from a thought to a published paper? Sometimes, a Banbury meeting helps the process along. Two years ago this week, the Banbury Center convened the Copper Cancer Consortium to discuss the importance of copper in biological functions such as angiogenesis, mitochondrial respiration, and...

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Research matters

Communications Department — Tue, 08 Jun 2021 18:00:08 +0000

When SARS-CoV-2 (coronavirus) spread throughout the world, 2020 immediately became a historic year. The virus recognized no boundaries; neither physical nor political. Our Cold Spring Harbor Asia conference center employees in Suzhou, China, were the first affected by the pandemic, and soon thereafter, in March, we faced COVID-19 in New York. Like people everywhere, Cold...

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Nicholas Tonks named 2019 AAAS Fellow

Sara Roncero-Menendez — Tue, 26 Nov 2019 16:00:03 +0000

Professor Nicholas Tonks has been named a 2019 Fellow of the American Association for the Advancement of Science (AAAS). Tonks is being honored in the field of Pharmaceutical Sciences for his contributions to our understanding of signal transduction, through the discovery of protein tyrosine phosphatases and the characterization of their structure, regulation, and function. In...

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Historic building—groundbreaking science

Brian Stallard — Tue, 29 Oct 2019 14:48:10 +0000

��ϳԹ��Դ (CSHL) is unique among cutting-edge research campuses. Along the waterside, you’ll find quaint cottages looking unchanged from their nineteenth-century whaling town origins. Deeper into these grounds, cottages are eclipsed by the red brick facades and sweeping arches that housed some of science’s first forays into genetics in the early 1900s. Deeper...

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Possible treatment for Wilson’s disease unexpectedly identified

Communications Department — Tue, 31 Jul 2018 15:27:47 +0000

Scientists report encouraging preclinical results of a small molecule called DPM-1001 that robustly reduces copper levels in cells and tissues. It is a potential treatment for Wilson’s disease, a serious genetic illness. Dr. Nicholas Tonks describes how the serendipity that is inherent to basic research played its part.

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Nicholas Tonks wins prestigious ASBMB award

Sara Roncero-Menendez — Tue, 03 Jul 2018 19:42:59 +0000

CSHL Professor Nicholas Tonks, the Caryl Boies Professor of Cancer Research, has been awarded the American Society for Biochemistry and Molecular Biology (ASBMB)’s 2019 Earl and Thressa Stadtman Distinguished Scientist Award. Tonks’ research has largely focused on the protein tyrosine phosphatase (PTP) family of enzymes, the “inaugural member” of which, PTP1B, he discovered in late...

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Progress toward improved Wilson’s disease drug

Peter Tarr — Wed, 27 Jun 2018 14:53:10 +0000

Cold Spring Harbor, NY — Researchers at ��ϳԹ��Դ (CSHL), working in collaboration with DepYmed Inc., a CSHL spinout company, today report that they have conducted promising preclinical experiments on a compound that could be used to treat Wilson’s disease and possibly other disorders—including certain types of cancer—in which levels of copper in...

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Portrait of a Neuroscience Powerhouse

Peter Tarr — Fri, 27 Apr 2018 16:07:30 +0000

At noon every Tuesday from September through June, scenes from a revolution in neuroscience are playing out at ��ϳԹ��Դ. Week after week, over 100 scientists cram themselves into a ground-floor meeting room in the Beckman Laboratory. It’s standing-room only as everyone in the Neuroscience Program settles in to hear details of the...

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The Joni Gladowsky Breast Cancer Foundation raises funds for breast cancer research

Jill Stone — Mon, 17 Jul 2017 16:00:00 +0000

On July 10, the Joni Gladowsky Breast Cancer Foundation held its annual golf tournament at Cold Spring Country Club. The event raises critical funding for ��ϳԹ��Դ’s breast cancer research program. Dr. Nick Tonks, Professor at the Laboratory gave an update to the Foundation’s supporters about the clinical trial that has resulted from...

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Drugging an undruggable target with Dr. Nicholas Tonks

Public Affairs Administrator — Tue, 12 Jul 2016 17:30:27 +0000

Hear a veteran research scientist take us on a personal journey that begins with his discovery 25 years ago of a key enzyme involved in cell signaling. Although it was clear that the enzyme, called PTP1B, was a potentially powerful target for new drugs to treat human diseases, Dr. Tonks was discouraged from pursuing this...

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Discovery of new ovarian cancer signaling hub points to target for limiting metastasis

Peter Tarr — Sun, 10 Jul 2016 17:00:38 +0000

The Tonks lab has identified a role for the non-receptor tyrosine kinase, FER, in the invasion and movement of ovarian cancer cells—two traits that are required for metastasis. The work points to a potential drug target that could limit the most aggressive form of the disease.

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Masthead Cove Yacht Club raises over $7000 for CSHL cancer research at annual race

Communications Department — Wed, 25 Nov 2015 14:26:37 +0000

Cold Spring Harbor, NY — Members of the Masthead Cove Yacht Club (MCYC) raised $7,124 from their annual Masthead Race on August 16. The proceeds were donated to support cancer research conducted by CSHL Professor Nicholas Tonks. The event has raised over $50,000 since it was started in 2006 in memory of the MCYC’s former...

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Breaking down breast cancer at CSHL

Andrea Alfano — Fri, 30 Oct 2015 19:46:10 +0000

reast cancer awareness is important, but it’s action that saves lives. Whether developing more accurate and affordable tests for patients or mapping out the treacherous landscape of breast cancer genetics, researchers at CSHL certainly aren’t putting the fight on pause even as the pink ribbons dissipate. Explore how they’re attacking breast cancer from an array...

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In mice, an experimental drug treatment for Rett syndrome suggests the disorder is reversible

Peter Tarr — Mon, 27 Jul 2015 16:00:35 +0000

Cold Spring Harbor, NY — A team at ��ϳԹ��Դ (CSHL) has developed a strikingly new approach for treating Rett syndrome, a devastating autism spectrum disorder (ASD) that affects 1 in 10,000 people in the US, mostly girls. In a paper appearing online today in the Journal of Clinical Investigation, Professor Nicholas Tonks,...

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Nicholas Tonks Archives | ���ϳԹ���Դ