metastasis Archives | ��ϳԹ��Դ

The Unspoken Truth: A Dialogue on Prostate Cancer

Communications Department — Tue, 30 Jun 2026 16:00:01 +0000

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Breast cancer case study could inform clinical trials

Jen A. Miller — Mon, 10 Nov 2025 12:30:14 +0000

MALAT1 (pink) than the surrounding tissues." data-description="Fluorescent microscopy image showing clusters of blue and purple cells on a black background." />When researchers look for potential cancer therapy targets, they typically go after protein-coding genes that participate in disease progression. Disrupt them and negate whatever role they play in cancer’s development or spread. Researchers at ��ϳԹ��Դ (CSHL) have also been working on another kind of target. They’re studying a long non-coding RNA called...

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Breast cancer discovery could help prevent recurrence

Margaret Osborne — Mon, 20 Oct 2025 11:30:07 +0000

Know someone who’s been diagnosed with breast cancer? There’s a good chance that person has received hormone therapy. Estrogen receptor-positive (ER+) breast cancers account for about 75 percent of cases. Hormone therapy is one of the most common and effective treatments. However, it’s far from a cure. Some ER+ tumors develop resistance. Many patients enter...

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The journey: One lab’s long winding road to cancer discovery

Margaret Osborne — Wed, 15 Oct 2025 11:30:59 +0000

As many as one in eight men in America will be diagnosed with prostate cancer at some point in their lives. About one in 44 will die from it. “Prostate cancer is very common,” ��ϳԹ��Դ (CSHL) Professor Lloyd Trotman says. “The vast majority of prostate cancers remain slow-growing and will never be...

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Borniger reaches Cancer Grand Challenges finals

Samuel Diamond — Wed, 24 Sep 2025 09:00:41 +0000

��ϳԹ��Դ (CSHL) Assistant Professor Jeremy Borniger has been selected for the final stages of a Cancer Grand Challenges research initiative as part of team NEUROIMPACT. The team seeks to determine how the nervous system senses and responds to cancers. In identifying the nervous system’s role in tumor growth and cancer metastasis, they...

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Go inside cancer’s biology

Nick Wurm — Mon, 22 Sep 2025 16:00:16 +0000

What happens inside and around a cancer cell? How does a tumor’s interaction with its surroundings contribute to cancer’s growth and spread? These questions could lead to a new generation of cancer therapies with fewer harmful side effects. Appropriately, they’re being asked and answered by a new generation of scientists at forums like the Cold...

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At the Lab Season 1 Research Rewind: Cancer

Communications Department — Tue, 08 Oct 2024 11:30:26 +0000

Miss an episode or two from the first season of our new podcast? Over the next few weeks, we’ll revisit each in a series we call ‘Research Rewind.’ This week At the Lab, you’ll hear all about our cutting-edge cancer research from CSHL scientists Semir Beyaz, Mikala Egeblad, Alea Mills, John Moses, and Christopher Vakoc....

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How does cancer spread? Follow the map

Jen A. Miller — Wed, 25 Sep 2024 11:30:07 +0000

Metastatic cancer can be a devastating diagnosis. The cancer is spreading. It may travel to multiple organs in the body. This could mean more pain and ultimately, death. Unfortunately, just how cancer spreads remains unclear. But now, ��ϳԹ��Դ (CSHL) Professor Adam Siepel and colleagues have a way to better understand that process....

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Test your breast cancer awareness

Communications Department — Wed, 18 Oct 2023 11:30:33 +0000

{“questions”:{“equ3q”:{“id”:”equ3q”,”mediaType”:”image”,”answerType”:”text”,”imageCredit”:””,”image”:”https:\/\/www.cshl.edu\/wp-content\/uploads\/2019\/12\/novel-therapy-target-triple-negative-breast-cancer.jpg”,”imageId”:”36481″,”video”:””,”imagePlaceholder”:””,”imagePlaceholderId”:””,”title”:”Some breast cancers lack two key hormone receptors as well as the HER2 receptor. What is this type of breast cancer called?”,”desc”:”In triple-negative breast cancer, the cancer cells don\u2019t have estrogen, progesterone, or HER2 receptors. As a result, this kind of cancer is very difficult to treat. CSHL Professor John Moses and Assistant Professor Michael...

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Metastatic breast cancer’s Trojan horse

Nick Wurm — Wed, 26 Jul 2023 11:30:34 +0000

Lymph nodes are one of the body’s first lines of defense against disease. Immune cells are dispatched from these biological police stations to fight off intruders. But somehow, lymph nodes are also the first stop for most metastatic cancers. “It’s paradoxical,” ��ϳԹ��Դ (CSHL) Assistant Professor Semir Beyaz says. “The cancer goes right...

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Cancer has a lot of nerve

Communications Department — Mon, 22 Aug 2022 11:30:51 +0000

« Previous Story Next Story » Manish Vira, a urologist at Northwell Health in New York performs prostate biopsy procedures three to five times a week. He inserts 12 needles into the prostate gland in specific locations, identified by MRI images that reveal malignant or suspicious lesions. The samples then go to a pathologist who...

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The prostate cancer cell that got away

Luis Sandoval — Tue, 16 Nov 2021 16:00:34 +0000

��ϳԹ��Դ (CSHL) Associate Professor Pavel Osten and Professor Lloyd Trotman have developed a new way to study the life history of prostate cancer in mice. The pair combined their expertise in whole-organ imaging and prostate cancer to track how prostate cancer cells grow into tumors and spread to other organs. Their method...

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Immune cells versus metastatic tumor cells

Eliene Augenbraun — Thu, 02 Sep 2021 20:30:37 +0000

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Extra chromosomes in cancers can be good or bad

Jennifer Michalowski — Mon, 24 Feb 2020 16:00:55 +0000

Cancer cells are notorious for their genetic disarray. A tumor cell can contain an abundance of DNA mutations and most have the wrong number of chromosomes. A missing or extra copy of a single chromosome creates an imbalance called aneuploidy, which can skew the activity of hundreds or thousands of genes. As cancer progresses, so...

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How cancer metabolism could be key for new therapies

Sara Roncero-Menendez — Wed, 05 Feb 2020 14:00:54 +0000

Biochemist Michael Lukey joins ��ϳԹ��Դ (CSHL) as the newest addition to its National Cancer Institute-designated Cancer Center. Lukey studies the metabolic reprogramming events that cancer cells undergo to feed tumor growth. He works on identifying vulnerabilities in these metabolic processes that can be targets for cancer therapy, including when breast cancer metastasizes...

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New book on metastasis: Mechanism to therapy from CSHL Press

Communications Department — Fri, 13 Dec 2019 14:00:09 +0000

Cold Spring Harbor, NY — ��ϳԹ��Դ Press (CSHLP) announced the release of Metastasis: Mechanism to Therapy, available on its website in Hardcover format. Nearly all types of cancer have the ability to metastasize, or spread from one organ or tissue in the body to another. Metastatic disease is responsible for the majority...

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Overcoming resistance in pancreatic cancer

Charlotte Hu — Mon, 09 Sep 2019 15:00:50 +0000

Cold Spring Harbor, NY — Cancer is relentless and resilient. When a drug blocks a cancer cell’s main survival pathway, the cell avoids the obstacle by taking different pathways or detours to save itself. This tactic is called “developing resistance,” and it’s one of the key challenges researchers face when seeking effective therapeutics to combat...

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Enzyme PHLPP2 could be a viable drug target for treating prostate cancer

Charlotte Hu — Wed, 15 May 2019 13:00:54 +0000

Cold Spring Harbor, NY — An estimated 450,000 Americans are diagnosed each year with a cancer that’s driven by MYC, an oncogene that hijacks growth and metabolism in cancer cells. MYC has a storied past of being notoriously hard for researchers to directly disable. “Now, we have a new way of getting at this old...

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Taking uncertainty out of cancer prognosis

Communications Department — Tue, 11 Dec 2018 20:09:34 +0000

An analysis of nearly 20,000 cancer patient histories and genetic data has revealed that knowing the genetic cause of a cancer does not help predict how deadly the disease will be. Instead, researchers from CSHL have discovered that copy number variations in specific gene sites are far more informative, providing new opportunities to improve prognosis.

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How a sleeping cancer awakens and metastasizes

Peter Tarr — Thu, 27 Sep 2018 18:00:29 +0000

Cold Spring Harbor, NY — Scientists at ��ϳԹ��Դ (CSHL) have determined one of the ways in which cancers in remission can spring back into action. This knowledge has inspired a new treatment idea designed to prevent cancer recurrence and metastasis. Even after successful cancer treatment, dormant, non-dividing cancer cells that previously detached...

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