immunotherapy Archives | ��ϳԹ��Դ

President’s message: Progress and opportunity for science and medicine

Communications Department — Tue, 09 Jun 2026 16:00:32 +0000

his is an extraordinary moment in time for the biomedical sciences. Seven decades ago, the discovery of the structure of DNA sparked a revolution in understanding life. In the decades since, the knowledge of fundamental biology we have accumulated has led to innovative treatments for many difficult-to-treat diseases, and many more are now within reach....

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CSHL develops endometrial cancer organoid platform

Nick Wurm — Thu, 26 Mar 2026 13:00:21 +0000

More than 68,000 women will be diagnosed with endometrial cancer in 2026. More than 14,000 will die from this condition. While some forms of the disease are treatable, high grade endometrial cancer often resists available immunotherapies. “High grade endometrial cancers (HGEC) are very aggressive,” explains ��ϳԹ��Դ Associate Professor Semir Beyaz. “Even when...

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Immune response to cancer may cause brain disease

Samuel Diamond — Wed, 25 Mar 2026 16:00:01 +0000

Consider two seemingly unrelated medical puzzles. First: Every day, our bodies produce hundreds of billions of new cells, many of which are mutated. If cancer arises from cellular mutation, why don’t we all have the disease all the time? Second: Severe autoimmune conditions like lupus and multiple sclerosis often strike without warning. No one knows...

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Corina Amor Vegas awarded $750K MIND Prize

Gina Dipietro — Tue, 10 Mar 2026 14:00:20 +0000

��ϳԹ��Դ (CSHL) Assistant Professor Corina Amor Vegas has been named a recipient of the Pershing Square Foundation’s 2026 Maximizing Innovation in Neuroscience Discovery (MIND) Prize. This coveted prize is awarded annually to five to seven early-to-mid-career investigators who dare to challenge conventional thinking around neurodegenerative diseases, including Alzheimer’s disease and dementia, which...

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Douglas Fearon elected as Fellow of AACR Academy

Samuel Diamond — Tue, 27 Jan 2026 15:30:54 +0000

Former ��ϳԹ��Դ (CSHL) Professor Douglas Fearon has been elected as a Fellow of the American Association for Cancer Research (AACR) Academy. He is recognized for championing research that helped link innate and adaptive immunity. Fundamental biology studies by Fearon and his colleagues significantly enhanced science’s understanding of the human immune system, thereby...

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Her science could help you live healthier, longer

Margaret Osborne — Mon, 17 Nov 2025 12:30:51 +0000

When Corina Amor Vegas was just 7 years old, her mother, Esperanza, was diagnosed with breast cancer. Esperanza’s treatment would take over a decade. However, after participating in a clinical trial for a new cancer drug, she entered remission. Today, Amor Vegas is happy to say her mother is doing “very well.” The clinical trial...

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BATMAN brings TCR therapy out of the shadows

Nick Wurm — Fri, 25 Jul 2025 15:00:02 +0000

Imagine your immune cells could be modified to attack any kind of cancer. T cell receptor (TCR) therapy has the potential to one day become a universal cancer treatment. But there are risks. Similarities between cancerous and healthy cells can affect the body’s immune response, causing T cells to attack unintended targets. TCR therapy needs...

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Cocktails & Chromosomes: The hidden world inside our cells

Communications Department — Thu, 20 Mar 2025 11:30:48 +0000

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‘Is cancer immunotherapy right for me?’

Communications Department — Tue, 21 Jan 2025 12:30:40 +0000

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The curious immune cells caught between worlds

Luis Sandoval — Tue, 24 Sep 2024 15:00:58 +0000

Our immune system spans two worlds—innate and adaptive. Innate immune cells are like troops at the gate ready to hold off invaders and raise the body’s alarms. Adaptive immune cells are specialists that take longer to respond but can fight off foes in a more targeted manner. Curiously, there are also immune cells that exist...

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Old chemo drug, new pancreatic cancer therapy?

Nick Wurm — Mon, 26 Aug 2024 11:30:57 +0000

The fight against cancer is an arms race, and one of the most effective weapons in clinicians’ arsenals is immunotherapy. Immune checkpoint therapy has become the standard for treating several types of cancer. However, the Nobel Prize-winning strategy is ineffective for most pancreatic ductal adenocarcinoma (PDAC) patients. “Immune checkpoint therapy is only an option in...

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Cocktails & Chromosomes: Why do we age?

Communications Department — Thu, 18 Jul 2024 11:30:26 +0000

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Chronic stress spreads cancer … here’s how

Margaret Osborne — Thu, 22 Feb 2024 16:00:10 +0000

Stress is inevitable. But too much of it can be terrible for our health. Chronic stress can increase our risk for heart disease and strokes. It may also help cancer spread. How this works has remained a mystery—a challenge for cancer care. Xue-Yan He, a former postdoc in ��ϳԹ��Դ (CSHL) Adjunct Professor...

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The immune system’s moonlighters

Luis Sandoval — Tue, 20 Feb 2024 12:30:43 +0000

Our immune system is remarkably powerful. It quickly assembles teams of cells to eliminate threats inside our bodies. But sometimes, it hits the wrong target. Autoimmune diseases like lupus and multiple sclerosis result from friendly fire—immune cells attacking healthy tissues and organs by mistake. New treatments and therapeutic targets are direly needed for these conditions....

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The fountain of youth is … a T cell?

Luis Sandoval — Wed, 24 Jan 2024 10:00:45 +0000

The fountain of youth has eluded explorers for ages. It turns out the magic anti-aging elixir might have been inside us all along. ��ϳԹ��Դ (CSHL) Assistant Professor Corina Amor Vegas and colleagues have discovered that T cells can be reprogrammed to fight aging, so to speak. Given the right set of genetic...

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Can we crack this cancer’s immune response?

Margaret Osborne — Wed, 29 Nov 2023 12:30:25 +0000

Recent findings at ��ϳԹ��Դ (CSHL) shine a new light on pancreatic cancer. More than 90% of pancreatic cancer cases are attributed to an aggressive, deadly form of the disease called pancreatic ductal adenocarcinoma, or PDAC. Researchers have a poor understanding of how our immune system interacts with PDAC. So, coming up with...

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In cancer immunotherapy, more isn’t necessarily better

Margaret Osborne — Thu, 14 Sep 2023 15:00:50 +0000

DNA mismatch repair deficiency (MMRd) is a genetic condition often associated with colon cancer. It can happen in otherwise normal cells before cancer forms or after a tumor has already formed. The condition makes it hard for cells to correct mistakes that occur in DNA copying. This can lead to many mutations within tumors, or...

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How popular steroids could mess up some cancer treatments

Margaret Osborne — Fri, 23 Jun 2023 15:00:50 +0000

Immunotherapy is among the newest and most potent weapons against cancer. It prompts the immune system to recognize tumors as intruders in the body and attack. But not all patients respond well to immunotherapy. Why? Scientists aren’t always sure. Sometimes, immunotherapy patients experience side effects that steroids called glucocorticoids (GCs) can treat. GCs are often...

Immunologist Peter Westcott joins CSHL faculty

Nick Wurm — Mon, 12 Sep 2022 14:00:11 +0000

Peter Westcott joins ��ϳԹ��Դ (CSHL) as an assistant professor and Cancer Center member on Sept. 6, 2022. Westcott’s research explores how the immune system shapes tumor evolution. His lab combines cancer genomics and immunology to understand how the immune system fails to react as cancer develops. He hopes this understanding may lead...

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How the thymus trains T cells to fight infections

Jennifer Michalowski — Tue, 02 Aug 2022 12:30:35 +0000

T cells are a special class of white blood cells that patrol the body and attack infected or foreign tissue. They learn to distinguish friendly proteins from dangerous ones in an organ called the thymus. However, when T cells mistakenly identify healthy proteins as foreign, it can lead to autoimmune disorders such as multiple sclerosis...

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