Genomics Archives | ��ϳԹ��Դ

How our biological clock starts and keeps ticking

Nick Wurm — Tue, 02 Jun 2026 11:30:14 +0000

C. elegans. The clock ensures that each of four larval stages begins precisely when it should, lasts as long as needed, and never repeats." data-description="A clock with twisting green hands and a spiral effect creating an illusion of infinite time." />Imagine a train parked at the station. Passengers climb aboard and find their seats. Conductors move up and down the aisles, checking tickets. But there’s a problem—the engineer’s watch is broken. As a result, the doors never close, the whistle never sounds, and the train never starts. Something similar occurs in cells when developmental timing...

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CSHL launches DNA Subway 2.0

Communications Department — Tue, 31 Mar 2026 11:30:26 +0000

The DNA Learning Center (DNALC) at ��ϳԹ��Դ has released DNA Subway 2.0, a comprehensive update to its globally recognized genomics education platform. DNA Subway 2.0 is the first bioinformatics toolkit engineered specifically for mobile interfaces, allowing students, educators, and researchers to analyze DNA sequences directly on smartphones and tablets. Bioinformatics—the data science...

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DEGU debuts with better AI predictions and explanations

Nick Wurm — Thu, 19 Feb 2026 12:30:55 +0000

Artificial intelligence has taken the world by storm. In biology, AI tools called deep neural networks (DNNs) have proven invaluable for predicting the results of genomic experiments. Their usefulness has these tools poised to set the stage for efficient, AI-guided research and potentially lifesaving discoveries—if scientists can work out the kinks. “Right now, there are...

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Dicer: Life’s ancient repair tool

Nick Wurm — Tue, 28 Oct 2025 15:00:47 +0000

Could yeast and humans be any more different? Going by looks alone, probably not. But peering into our genomes reveals surprising similarities. That’s because we share a common ancestor called LECA (last eukaryotic common ancestor). Before this single-celled organism died off around 2 billion years ago, it passed down Dicer, a key protein humans and...

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Cocktails & Chromosomes: Heresy in genetics

Communications Department — Tue, 17 Jun 2025 11:30:54 +0000

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Exposomics: Holistic health without the snake oil

Samuel Diamond — Thu, 12 Jun 2025 11:30:27 +0000

We live in the age of -omics. We have genomics to study complete sets of DNA. We have proteomics focused on all the proteins within our cells. And we have metabolomics for metabolites like sugars and lipids. Despite their massive reach and intense focus, these fields have blind spots. They’re both in the margins and...

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CSHL and global collaborators map Solanum pan-genome

Margaret Osborne — Wed, 05 Mar 2025 16:00:00 +0000

AI generated voice with Zachary Lippman’s actual voice About 75 percent of the world’s food comes from 12 plants. Scientists estimate up to 30,000 species are edible. Not only does this bottleneck jeopardize our food supply if a major crop is impacted by drought or disease—it also limits our choices at the grocery store. For...

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Corn’s ancient ancestors are calling

Jen A. Miller — Thu, 06 Feb 2025 12:30:17 +0000

AI generated voice with Rob Martienssen’s and Thomas Gingeras’s actual voices The domestication of maize is one of the greatest examples of humankind’s impact on evolution. Early farmers’ pre-industrial plant breeding choices turned corn from a nearly inedible crop into the major global food source it is today. Now, ��ϳԹ��Դ Professors Rob...

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Big clues emerge in small RNA mystery

Jen A. Miller — Mon, 16 Dec 2024 12:30:00 +0000

Arabidopsis plant (as seen above) is loaded with a molecule called pseudouridine." data-description="" />AI generated voice with Rob Martienssen’s actual voice Not everything inside us is, strictly speaking, us. The closer we look at the genome, the more we appreciate the role of small RNAs in what we call epigenetic inheritance. That’s when traits get passed down without altering our basic DNA sequence. We now know that small...

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Cocktails & Chromosomes: Long-lived creatures of the night

Communications Department — Tue, 19 Nov 2024 12:30:08 +0000

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New DNALC program aims to improve pandemic response

Nick Wurm — Mon, 04 Nov 2024 12:30:15 +0000

Diseases can spread rapidly, but now, so can the knowledge needed to stop them. A new information-sharing platform seeks to help slow the spread of infectious diseases. It’s called the Pathogen Data Network (PDN). And it just might help stop the next pandemic before it can start. ��ϳԹ��Դ’s DNA Learning Center (DNALC)...

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At the Lab Season 1 Research Rewind: Genetics

Communications Department — Tue, 22 Oct 2024 11:30:28 +0000

Much of what makes humans human is also found across all animal and plant life. In other words, genetics is everywhere you look. That’s especially true here At the Lab. This week’s Research Rewind features scientists from all across CSHL, including Christopher Hammell, Ivan Iossifov, Tobias Janowitz, Zachary Lippman, and Rob Martienssen. We also check...

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At the Lab Episode 26: The golden grail of genomics

Communications Department — Tue, 01 Oct 2024 11:30:21 +0000

First, there was the Human Genome Project. Then, there was ENCODE. CSHL Professor Thomas Gingeras recently spoke with Scientific American about the legacy of ENCODE. This week At the Lab, he talks about a new follow-up project called EN-TEx and its promise for the coming era of personalized medicine. Thank you for joining us for...

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At the Lab Episode 25: How maize became corn

Communications Department — Tue, 24 Sep 2024 11:30:36 +0000

The journey from maize to corn isn’t just about going from farm to table. It starts with an evolutionary event that has puzzled plant biologists for decades. This week At the Lab, CSHL Professor, HHMI Investigator, and Genetics Society Medal recipient Rob Martienssen unravels a 4,000-year-old mystery in just over three minutes.

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CSHL grad student wins International Birnstiel Award

Nick Wurm — Mon, 23 Sep 2024 11:30:55 +0000

��ϳԹ��Դ (CSHL) School of Biological Sciences (SBS) graduate Shushan Toneyan has won the 2024 International Birnstiel Award for Doctoral Research in Molecular Life Sciences. A member of the SBS Class of 2024, Toneyan is one of six recipients of this year’s award. She received it in recognition of her thesis research in...

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Is CREME AI’s answer to CRISPR?

Luis Sandoval — Mon, 16 Sep 2024 09:00:02 +0000

Imagine you’re looking at millions upon millions of mysterious genetic mutations. With CRISPR gene-editing technology, a select few of these mutations might have therapeutic potential. However, proving it would mean many thousands of hours of lab work. Just figuring out which ones are worth exploring further would take a lot of time and money. But...

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Corn’s ‘missing link’

Margaret Osborne — Wed, 07 Aug 2024 15:00:25 +0000

Teosinte Pollen Drive (TPD) is a selfish genetic system in maize-teosinte hybrids, which allows only pollen with both toxin and antidote to survive. Here, we see the pollen-producing part of the maize-teosinte hybrid. Image: Jon Cahn/Martienssen lab" data-description="" />��ϳԹ��Դ (CSHL) has begun to unravel a mystery millennia in the making. Our story begins 9,000 years ago. It was then that maize was first domesticated in the Mexican lowlands. Some 5,000 years later, the crop crossed with a species from the Mexican highlands called teosinte mexicana. This resulted in cold adaptability....

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Every rose has its thorns … or does it?

Margaret Osborne — Thu, 01 Aug 2024 18:00:23 +0000

According to Greek mythology, red roses first appeared when Aphrodite pricked her foot on a thorn, spilling blood on a white rose. Since then, roses’ thorns have captured the imaginations of countless poets and forlorn lovers. But they aren’t the only plants with these dangerous protrusions, technically called prickles. Prickles have evolved independently in species...

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At the Lab Episode 17: AI SQUID

Communications Department — Tue, 30 Jul 2024 11:30:05 +0000

We could have also titled this At the Lab episode “20,000 leagues under the genome.” This week, you’ll hear all about SQUID, the new artificial intelligence tool from CSHL Assistant Professor Peter Koo and Associate Professor Justin Kinney. How can this AI help scientists crack the mysteries of the genome? Tune in to find out.

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Welcome to the summer of sequencing

Communications Department — Wed, 17 Jul 2024 11:30:32 +0000

What do a shoe and a cotton swab have in common? Aside from the cotton, they are both part of the most exciting summer school you’ve ever heard of. The Summer of Nanopore Sequencing 2024 was a three-day nationwide workshop series held by ��ϳԹ��Դ’s DNA Learning Center (DNALC) in collaboration with Oxford...

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Genomics Archives | ���ϳԹ���Դ