Douglas Fearon Archives | ��ϳԹ��Դ

Douglas Fearon elected as Fellow of AACR Academy

Samuel Diamond — Tue, 27 Jan 2026 15:30:54 +0000

Former ��ϳԹ��Դ (CSHL) Professor Douglas Fearon has been elected as a Fellow of the American Association for Cancer Research (AACR) Academy. He is recognized for championing research that helped link innate and adaptive immunity. Fundamental biology studies by Fearon and his colleagues significantly enhanced science’s understanding of the human immune system, thereby...

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Old chemo drug, new pancreatic cancer therapy?

Nick Wurm — Mon, 26 Aug 2024 11:30:57 +0000

The fight against cancer is an arms race, and one of the most effective weapons in clinicians’ arsenals is immunotherapy. Immune checkpoint therapy has become the standard for treating several types of cancer. However, the Nobel Prize-winning strategy is ineffective for most pancreatic ductal adenocarcinoma (PDAC) patients. “Immune checkpoint therapy is only an option in...

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Can we crack this cancer’s immune response?

Margaret Osborne — Wed, 29 Nov 2023 12:30:25 +0000

Recent findings at ��ϳԹ��Դ (CSHL) shine a new light on pancreatic cancer. More than 90% of pancreatic cancer cases are attributed to an aggressive, deadly form of the disease called pancreatic ductal adenocarcinoma, or PDAC. Researchers have a poor understanding of how our immune system interacts with PDAC. So, coming up with...

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��ϳԹ��Դ 2022 Ph.D.’s

Communications Department — Sun, 01 May 2022 22:00:07 +0000

The ��ϳԹ��Դ (CSHL) School of Biological Sciences takes an innovative approach to advanced education. Graduates of the doctoral program pursue diverse careers. This year, ten students were awarded Ph.D. degrees. Here they recall memories and experiences that they take from the Laboratory moving forward. Brianna Lynn Bibel St. Mary’s College of California...

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Deactivating pancreatic cancer’s protective coat of arms

Communications Department — Thu, 17 Feb 2022 12:30:06 +0000

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Pushing past pancreatic tumors’ defenses

Luis Sandoval — Wed, 16 Feb 2022 12:30:39 +0000

Our immune systems have the potential to find and destroy cancer cells. But cancer cells can be clever and develop tricks to evade the immune system. ��ϳԹ��Դ Professor Douglas Fearon and his former postdoc ZhiKai Wang found one such trick. Cancer cells weave a deactivating signal into a protective coat of armor...

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��ϳԹ��Դ the immune system a double boost against cancer

Jennifer Michalowski — Fri, 30 Oct 2020 19:34:18 +0000

Cancer immunotherapies, which empower patients’ immune systems to eliminate tumors, are revolutionizing cancer treatment. Many patients respond well to these treatments, sometimes experiencing long-lasting remissions. But some cancers remain difficult to treat with immunotherapy, and expanding the impact of the approach is a high priority. In the October 30 issue of the Proceedings of the...

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Big bold dreamers

Communications Department — Mon, 10 Dec 2018 19:00:24 +0000

2018 Double Helix Medal honoree Dr. Larry Norton has dedicated his career to ridding the world of cancer. Under the belly of the blue whale at the American Museum of Natural History, he reminded us that big dreams can come true. Larry shared childhood memories of visiting the museum with his mother. Pulling on her...

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Base Pairs Episode 15.5: Cellular hide and seek

Sara Roncero-Menendez — Fri, 15 Jun 2018 20:57:25 +0000

Base Pairs podcast - Learn how William Coley's daughter founded the Cancer Research Institute, Professor Fearon on the immune system, and white blood cells on screen.

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How pancreatic cancer spreads after surgery

Peter Tarr — Thu, 17 May 2018 18:00:44 +0000

Cold Spring Harbor, NY — Scientists at ��ϳԹ��Դ (CSHL) have solved a mystery about how pancreatic cancer spreads following surgery in patients whose tumor is successfully removed. After surgery, patients typically experience a two-week period during which their immune system is depleted as a result of a surge in post-operative stress hormone...

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How deadly cancer spreads after surgery

Communications Department — Thu, 17 May 2018 13:56:51 +0000

Scientists at ��ϳԹ��Դ (CSHL) have solved an important mystery about how pancreatic cancer spreads to the liver even after a successful surgery.

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The immune system, unleashed

Sara Roncero-Menendez — Tue, 15 May 2018 15:44:52 +0000

Base Pairs podcast Many stories start the same. Boy meets girl, they fall in love, and there’s a happy ending. In the story of Elizabeth “Bessie” Dashiell, that boy was John D. Rockefeller, Jr., and by all accounts they should have gotten their happily-ever-after. But Bessie was in a minor accident, getting her hand caught...

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Base Pairs Episode 15: The immune system unleashed

Communications Department — Tue, 15 May 2018 15:41:37 +0000

Base Pairs podcast - Cancer immunotherapy has a long and storied history, one that begins with a young woman suffering from a pain in her hand.

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Bringing immune cells back into the cancer fight

Peter Tarr — Fri, 04 May 2018 17:51:21 +0000

The human immune system protects us so reliably against most bacterial infections and viruses. We owe our lives to it. So why doesn’t it just as reliably prevent us from getting cancer? Most experts agree that the immune system does indeed suppress the formation of cancers. Immune cells vanquish viruses that by some estimates cause...

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One experiment: When cancer is hiding in plain sight

Peter Tarr — Thu, 01 Mar 2018 15:28:20 +0000

Everyone knows how important the immune system is—our lives utterly depend upon it. Its role in fighting bacteria and common viruses is something we take for granted. Few people know that its protection extends to viruses that can cause cancer. And yet cancer is so common. When it strikes, is the immune system letting us...

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Turning off the immune system is hard. Turning it on against cancer is easier.

Andrea Alfano — Wed, 10 Jan 2018 21:14:38 +0000

he immune system’s awesome power has captivated Professor Douglas Fearon throughout over 45 years of study, both as a medical doctor and as a scientist. Yet just 10 years ago, he “didn’t believe in cancer immunology,” he admits frankly. Today, cancer drugs based on the idea of harnessing the immune system’s power are helping to...

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The latest research in immunotherapy and cancer

Public Affairs Administrator — Fri, 28 Jul 2017 20:43:56 +0000

Our own immune system can help fight cancer. Doctors Douglas Fearon (CSHL) and Robert Maki (Northwell Health) talk about the latest science and how immunotherapy is already affecting patient lives.

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Pancreas and colon tumors reprogram the liver, causing wasting and short-circuiting body’s immune response

Peter Tarr — Tue, 08 Nov 2016 12:00:13 +0000

Many cancer patients suffer from extreme weight loss in a condition known as cachexia. The Fearon lab has found that this calorie deprivation can have profound implications for tumor immunology, allowing tumor cells to become resistant to immunotherapy.

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New senior faculty join CSHL

Communications Department — Mon, 10 Nov 2014 21:29:51 +0000

This fall, the Lab welcomes six new faculty members. They’re a diverse group—a mix of junior and senior investigators, with research spanning across Biology. Want to know a little more? We’ll be featuring brief profiles all week. So check back for more! Professor Douglas Fearon, Cancer Where are you from? The University of Cambridge, England...

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Douglas Fearon Archives | ���ϳԹ���Դ