disease biomarkers Archives | ��ϳԹ��Դ

On the trail of a cellular cold case

Nick Wurm — Tue, 16 Dec 2025 17:00:43 +0000

If you remember high school biology, you know cells pack a lot inside a tiny package. Inside the nucleus of every one of our cells, you’ll see more than a few things floating around. You may be familiar with RNA and DNA. But that’s not all you’ll find there. Over a century ago, scientists discovered...

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Exposomics: Holistic health without the snake oil

Samuel Diamond — Thu, 12 Jun 2025 11:30:27 +0000

We live in the age of -omics. We have genomics to study complete sets of DNA. We have proteomics focused on all the proteins within our cells. And we have metabolomics for metabolites like sugars and lipids. Despite their massive reach and intense focus, these fields have blind spots. They’re both in the margins and...

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At the Lab: The nuclear speckle option

Communications Department — Tue, 06 May 2025 11:30:52 +0000

This week At the Lab, we’re joined by CSHL Assistant Professor Katherine Alexander, the newest member of the ��ϳԹ��Դ faculty. We’ll also hear about a Spanish bodybuilder who’s been dead for more than 90 years. How in the world are these individuals connected? Hit play to hear all about it.

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Cocktails & Chromosomes: The hidden world inside our cells

Communications Department — Thu, 20 Mar 2025 11:30:48 +0000

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‘Is cancer immunotherapy right for me?’

Communications Department — Tue, 21 Jan 2025 12:30:40 +0000

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A speckle of hope for cancer patients

Luis Sandoval — Thu, 02 Jan 2025 10:00:42 +0000

Nature Cell Biology. " data-description="" />AI generated voice with Kate Alexander’s actual voice Fighting cancer can seem like a deadly game of chance. While some patients may respond well to certain treatments, others might not be as fortunate. Doctors and scientists have long struggled to explain why. Now, ��ϳԹ��Դ (CSHL) Assistant Professor Katherine Alexander and University of...

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At the Lab Episode 5: A heart of golf

Communications Department — Tue, 30 Apr 2024 11:30:05 +0000

Leonardo da Vinci was a real heartbreaker. Five hundred years ago, he produced a series of sketches breaking down the human heart’s anatomical structure. One part looks like cobblestone and works like … a golf ball? ��ϳԹ��Դ Assistant Professor Hannah Meyer uses modern data science to pick up where da Vinci left...

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In cancer immunotherapy, more isn’t necessarily better

Margaret Osborne — Thu, 14 Sep 2023 15:00:50 +0000

DNA mismatch repair deficiency (MMRd) is a genetic condition often associated with colon cancer. It can happen in otherwise normal cells before cancer forms or after a tumor has already formed. The condition makes it hard for cells to correct mistakes that occur in DNA copying. This can lead to many mutations within tumors, or...

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A full-circle moment in cancer research

Communications Department — Wed, 16 Aug 2023 11:30:45 +0000

High-tech experiments by CSHL Postdoctoral Researcher Asad Lakhani and colleagues allow us to see early 20th-century hypotheses in a whole new light.

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Genome hack reignites century-old cancer debate

Luis Sandoval — Mon, 14 Aug 2023 11:30:10 +0000

What causes cancer? Science and medicine have been trying to answer this question for centuries. In the late 1800s, scientists observed that most tumors have an odd number of chromosomes. They thought this imbalance, called aneuploidy, may be a driving force in cancer development. Since then, technological advancements—and limitations—have pushed science in other directions. But...

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Targeting cancer’s Achilles heel

Communications Department — Fri, 04 Nov 2022 11:30:01 +0000

« Previous Story Next Story » Matthew Weiss dreams of the day when his oncology practice will operate very differently. A surgeon at the Northwell Health System in New York who treats pancreatic cancer—one of the deadliest malignancies known—he doesn’t have a lot of choices when it comes to saving his patients. Some people with...

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Understanding the inner workings of the human heart

Communications Department — Wed, 19 Aug 2020 15:00:25 +0000

Researchers have investigated the function of a complex mesh of muscle fibers that line the inner surface of the heart. The study, published in the journal Nature, sheds light on questions asked by Leonardo da Vinci 500 years ago, and shows how the shape of these muscles impacts heart performance and heart failure. In humans,...

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How an antiviral immune reaction can go too far

Brian Stallard — Sat, 23 May 2020 13:00:18 +0000

Cold Spring Harbor Lab Associate Professor Mikala Egeblad studied cancer before the COVID-19 pandemic. But when she read reports about severe cases of the disease, she realized that those coronavirus patients might suffer from something similar to what some cancer patients experience. Neutrophils, a common type of white blood cells, try to trap and digest...

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Coronavirus research in plants

Eliene Augenbraun — Fri, 15 May 2020 15:21:51 +0000

When ��ϳԹ��Դ (CSHL) was asked to help produce critically needed reagents (coronavirus proteins) for COVID-19 research, the Lab’s plant biologists came up with a plan: Let’s produce the requested proteins cheaply, quickly, and in large quantities, in tobacco and duckweed. CSHL Professor David Jackson said that for the plant researchers, it all...

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Seeking better treatment for ALS, Lou Gehrig’s disease

Charlotte Hu — Tue, 29 Oct 2019 15:00:59 +0000

There is currently no cure for amyotrophic lateral sclerosis (ALS). But new research could open up avenues for better diagnosis and more effective treatment. The study, led by ��ϳԹ��Դ Associate Professor Molly Gale Hammell, analyzed the role proteins called TDP-43 play in ALS, also known as Lou Gehrig’s disease. In ALS, those...

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Sugars that coat proteins are a possible drug target for pancreatitis

Charlotte Hu — Thu, 20 Jun 2019 18:00:22 +0000

Cold Spring Harbor, NY — Pancreatitis is an inflammation of the pancreas that accounts for 275,000 hospitalizations in the United States annually. Patients who suffer from hereditary pancreatitis have a 40 to 50 percent lifetime risk of developing pancreatic cancer. Dannielle Engle, a former ��ϳԹ��Դ (CSHL) Cancer Center postdoctoral fellow who was...

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New method identifies splicing biomarkers for liver cancer

Communications Department — Fri, 02 Mar 2018 17:52:49 +0000

Cold Spring Harbor, NY — Because liver cancer is particularly diverse, genetically, and prone to relapse, identifying biomarkers that can predict disease progression is a critical goal in the fight against it. Researchers at ��ϳԹ��Դ (CSHL), led by CSHL Professor Adrian Krainer, now report in Genome Research that they have developed a...

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