diabetes Archives | ��ϳԹ��Դ

A steadfast commitment to discovery

Lisa Cruz — Tue, 14 Apr 2026 11:30:21 +0000

For more than 30 years, Edward Chernoff has been a devoted champion of ��ϳԹ��Դ (CSHL), offering both leadership and friendship to the institution he first encountered as a young science enthusiast. While his professional life led him into the family’s air-conditioning and refrigeration business, Motors & Armatures (MARS), Chernoff’s early academic grounding...

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Researchers find new way to slow memory loss in Alzheimer’s

Gina Dipietro — Thu, 05 Feb 2026 12:30:28 +0000

Alzheimer’s disease is often measured in statistics: millions affected worldwide, cases rising sharply, costs climbing into the trillions. For families, the disease is experienced far more intimately. “It’s a slow bereavement,” says ��ϳԹ��Դ Professor Nicholas Tonks, whose mother lived with Alzheimer’s. “You lose the person piece by piece.” There’s a lot of...

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A recipe to reverse cancer’s sweet tooth

Nick Wurm — Mon, 16 Jun 2025 11:30:58 +0000

Sometimes sugar isn’t so sweet. Sometimes, it’s downright deadly. Glycation occurs when an excess of sugars called reducing sugars attach to important proteins in the body. The process has been linked to diabetes and obesity. It’s usually something to avoid, and the body relies on the FN3K kinase to break glycation down. But cancer flips...

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A CSHL Symposium for the ages

Samuel Diamond — Thu, 05 Jun 2025 11:30:05 +0000

You are not the same person you were a decade ago. Most of your body’s cells are replaced every seven to 10 years. Nevertheless, you retain the genes and memories that help make you, you. Science still doesn’t fully understand how the aging process works. But we’re getting closer, and the answers may hold the...

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Cocktails & Chromosomes: Why do we age?

Communications Department — Thu, 18 Jul 2024 11:30:26 +0000

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Women in science on women’s health

Jennifer Michalowski — Fri, 08 Mar 2024 12:30:18 +0000

You’ve heard the phrase, “Men are from Mars, women are from Venus.” If only it were so simple. The fact is that all of us are from Earth. Yet, there are clear physical and neurological differences between the sexes. Women comprise half the world’s population. However, when it comes to health conditions that primarily affect...

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The fountain of youth is … a T cell?

Luis Sandoval — Wed, 24 Jan 2024 10:00:45 +0000

The fountain of youth has eluded explorers for ages. It turns out the magic anti-aging elixir might have been inside us all along. ��ϳԹ��Դ (CSHL) Assistant Professor Corina Amor Vegas and colleagues have discovered that T cells can be reprogrammed to fight aging, so to speak. Given the right set of genetic...

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Bite into this diet and disease quiz

Communications Department — Wed, 05 Jul 2023 11:30:26 +0000

{“questions”:{“fmpo8”:{“id”:”fmpo8″,”mediaType”:”image”,”answerType”:”text”,”imageCredit”:””,”image”:”https:\/\/www.cshl.edu\/wp-content\/uploads\/2021\/09\/normal-mouse-small-intestine.jpg”,”imageId”:”56101″,”video”:””,”imagePlaceholder”:””,”imagePlaceholderId”:””,”title”:”Which one of these diets makes it harder for the immune system to recognize and attack colorectal cancer in mice?”,”desc”:”CSHL Assistant Professor Semir Beyaz has found that a high-fat diet masks intestinal cancer in mice by suppressing a cell tag called MHC-II. When these tags were reduced in mice, their immune systems didn\u2019t recognize potentially...

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Humans of Banbury: Interview with Marcus Goncalves

Jenna Jacobs — Wed, 31 May 2023 15:24:02 +0000

In March 2023, the Banbury Center welcomed experts for “The Future of Investigational Medicine: Utilizing Science to Optimize the Early Phase Oncology Clinical Trial Effort.” During the meeting, I had the opportunity to sit down with Marcus Goncalves, M.D., Ph.D. Dr. Goncalves is an endocrinologist and laboratory scientist at Weill Cornell Medicine. He received his...

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Your diet is your future

Communications Department — Wed, 03 May 2023 11:30:50 +0000

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Amor Vegas wins NIH Director’s Early Independence Award

Nick Wurm — Tue, 04 Oct 2022 19:00:32 +0000

��ϳԹ��Դ (CSHL) Fellow Corina Amor Vegas has been awarded the U.S. National Institutes of Health (NIH) Director’s Early Independence Award. The grant provides up to $1.25 million over five years. It supports Amor Vegas’ investigations into how the aging process is affected by cellular senescence—when cells stop dividing but don’t die. She...

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Targeted delivery of CRISPR interference system against Fabp4 to white adipocyte ameliorates obesity, inflammation, hepatic steatosis, and insulin resistance

Communications Department — Thu, 29 Aug 2019 13:44:04 +0000

Gene therapy reduces obesity and reverses type 2 diabetes in mice.

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��ϳԹ��Դ and GSK to develop diabetes and obesity therapeutic

Communications Department — Mon, 23 Mar 2015 06:30:20 +0000

Cold Spring Harbor, NY — ��ϳԹ��Դ (CSHL) today announced a collaboration with GSK to develop a treatment for obesity and type 2 diabetes. Scientists at CSHL and GSK will pursue drug development based on a novel approach to regulate the enzymatic activity of the phosphatase PTP1B. The goal of the multi-year CSHL-GSK...

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Nobelist James Watson proposes an unconventional view of type 2 diabetes causation

Peter Tarr — Thu, 27 Feb 2014 19:30:45 +0000

A new hypothesis published in the British medical journal The Lancet Cold Spring Harbor, NY — At 85, Nobel laureate James D. Watson, the co-discoverer of the double-helix structure of DNA, continues to advance intriguing scientific ideas. His latest, a hypothesis on the causation of type 2 diabetes, appears online February 28th in The Lancet,...

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Powerful antibody-based strategy suggests a new therapeutic approach to diabetes and obesity

Peter Tarr — Thu, 29 Sep 2011 15:19:22 +0000

Cold Spring Harbor, NY — The work of a team of scientists at ��ϳԹ��Դ (CSHL) led by Professor Nicholas Tonks FRS, suggests a way to overcome one of the major technical obstacles preventing a leading therapeutic target for diabetes and obesity from being addressed successfully by novel drugs. The target is an...

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