David McCandlish Archives | ��ϳԹ��Դ

Branching out: Tomato genes point to new medicines

Samuel Diamond — Wed, 09 Jul 2025 15:00:49 +0000

Picture juicy red tomatoes on the vine. What do you see? Some tomato varieties have straight vines. Others are branched. The question is why. New research from ��ϳԹ��Դ (CSHL) provides the strongest evidence to date that the answer lies in what are called cryptic mutations. The findings have implications for agriculture and...

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In nature’s math, freedoms are fundamental

Samuel Diamond — Wed, 28 May 2025 11:30:07 +0000

Numbers have a funny way about them. Young math students are taught various strategies to make problem-solving easier. Comparing fractions? Find a common denominator or convert to decimals. The strategies get more complex when doing the kind of math used to describe the activities of DNA, RNA, or protein sequences. In science, when you make...

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You say genome editing, I say natural mutation

Luis Sandoval — Thu, 19 Oct 2023 18:00:46 +0000

For tens of thousands of years, evolution shaped tomatoes through natural mutations. Then, humans came along. For centuries, we’ve bred and cherry-picked tomatoes with our preferred traits. Today, CRISPR genome editing allows us to make new crop mutations that improve traits even further. However, individual mutations, whether natural or engineered, don’t work alone. Each operates...

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How evolved is your knowledge?

Nick Fiore — Thu, 26 Jan 2023 12:30:06 +0000

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Getting a step ahead of TB’s drug resistance evolution

Jennifer Michalowski — Tue, 15 Feb 2022 12:30:17 +0000

In the face of natural selection, genetic mutations set some individuals up for success. A single change to the sequence of a gene can give an organism an advantage—and if that mutation is passed to future generations, it may shape the fate of the species. Now, scientists have determined that evolutionary adaptation is steered in...

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Calculating the path of cancer

Jennifer Michalowski — Mon, 04 Oct 2021 17:00:02 +0000

Biologists at ��ϳԹ��Դ (CSHL) are using a mathematical approach developed in CSHL Assistant Professor David McCandlish’s lab to find solutions to a diverse set of biological problems. Originally created as a way to understand interactions between different mutations in proteins, the tool is now being used by McCandlish and his collaborators to...

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How to outwit evolution

Communications Department — Wed, 21 Jul 2021 12:30:41 +0000

Every 15 minutes, someone in America dies from antibiotic-resistant bacteria or fungi, adding up to 35,000 annual deaths. Globally, the United Nations reports that a mind-boggling 700,000 people a year die from infections that antibiotics can no longer fight. The report warns that this number could reach 10 million by 2050 if scientists don’t find...

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Predicting the evolution of genetic mutations

Brian Stallard — Tue, 14 Apr 2020 09:00:04 +0000

Quantitative biologists David McCandlish and Juannan Zhou at ��ϳԹ��Դ have developed an algorithm with predictive power, giving scientists the ability to see how specific genetic mutations can combine to make critical proteins change over the course of a species’s evolution. Described in Nature Communications, the algorithm called “minimum epistasis interpolation” results in...

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A science career path: David McCandlish

Brian Stallard — Fri, 10 Apr 2020 13:00:19 +0000

His interdisciplinary research began by reading a book. hen you see his office, with books stacked from floor to ceiling and papers strewn across desks, it’s clear that David McCandlish is an avid reader. As an assistant professor and quantitative biologist at CSHL, McCandlish endeavors to stay up to date on the newest and greatest...

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Peter Koo wants to understand how machines learn biology

Charlotte Hu — Fri, 20 Sep 2019 13:00:59 +0000

The science world is sitting at the cusp of an artificial intelligence revolution that impacts applications such as speech recognition and computer vision. Peter Koo is on the front line of those changes. As ��ϳԹ��Դ’s new Assistant Professor at the Simons Center for Quantitative Biology, Koo will explore how AI integrates with...

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Public Lecture: Seeing With Sequencing

Public Affairs Administrator — Thu, 08 Aug 2019 15:58:37 +0000

Come hear from three quantitative biologists as they discuss how they see with sequencing to solve mysteries ranging from the genetics of evolution.

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Seeing with sequencing—A public lecture with three CSHL experts

Communications Department — Fri, 19 Apr 2019 18:15:03 +0000

Over 400 years ago, the invention of the microscope opened up a new world of discovery. Just sixteen years ago, the completion of the Human Genome Project launched a similar revolution in science.

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David McCandlish named Sloan Research Fellow

Sara Roncero-Menendez — Tue, 19 Feb 2019 15:00:31 +0000

Assistant Professor David McCandlish has been named a 2019 Sloan Research Fellow. McCandlish is a quantitative biologist at ��ϳԹ��Դ (CSHL), where he develops computational and mathematical tools to analyze genetic data. His lab focuses specifically on analyzing data from so-called “deep mutational scanning” experiments, which determine, for a single protein, the functional...

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David McCandlish Archives | ���ϳԹ���Դ