David L. Spector Archives | ��ϳԹ��Դ

Breast cancer case study could inform clinical trials

Jen A. Miller — Mon, 10 Nov 2025 12:30:14 +0000

MALAT1 (pink) than the surrounding tissues." data-description="Fluorescent microscopy image showing clusters of blue and purple cells on a black background." />When researchers look for potential cancer therapy targets, they typically go after protein-coding genes that participate in disease progression. Disrupt them and negate whatever role they play in cancer’s development or spread. Researchers at ��ϳԹ��Դ (CSHL) have also been working on another kind of target. They’re studying a long non-coding RNA called...

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Special edition: Breast Cancer Awareness Month

Communications Department — Thu, 23 Oct 2025 11:30:49 +0000

Today, the five-year survival rate for early-stage breast cancer is about 99%. Awareness drives detection. But what about those breast cancers that aren’t caught early? What about those that evade common therapies? For Breast Cancer Awareness Month, we sat down with CSHL Professor David Spector to discuss some of his lab’s latest research and the...

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Inspiring breast cancer breakthroughs

Communications Department — Mon, 18 Aug 2025 17:30:23 +0000

Breast cancer is one of the most common cancers among women in the United States, second only to skin cancer. Thanks to decades of fundamental research, it’s also one of the most curable. However, challenges remain, especially when confronting aggressive varieties like triple-negative breast cancer. ��ϳԹ��Դ (CSHL) has a rich history of...

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A new “link” to triple-negative breast cancer

Margaret Osborne — Mon, 30 Jun 2025 14:00:38 +0000

LINC01235 is seen in red." data-description="" />Breast cancer is one of the most common cancers among women in the United States. Thanks to decades of fundamental research, it’s also one of the most curable. The exception is a particularly aggressive variant known as triple-negative breast cancer (TNBC). It accounts for 10 to 15 percent of all breast cancer cases. It disproportionately...

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Joshua-Tor named CSHL Director of Research

Samuel Diamond — Tue, 02 Jan 2024 12:35:35 +0000

��ϳԹ��Դ (CSHL) Professor and HHMI Investigator Leemor Joshua-Tor has been named CSHL Director of Research. She takes over the position effective January 2, 2024. Research at CSHL explores the frontiers of cancer, neuroscience, genomics, quantitative biology, and plant biology. The Joshua-Tor lab, one of more than 60 at CSHL, studies gene expression...

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Test your breast cancer awareness

Communications Department — Wed, 18 Oct 2023 11:30:33 +0000

{“questions”:{“equ3q”:{“id”:”equ3q”,”mediaType”:”image”,”answerType”:”text”,”imageCredit”:””,”image”:”https:\/\/www.cshl.edu\/wp-content\/uploads\/2019\/12\/novel-therapy-target-triple-negative-breast-cancer.jpg”,”imageId”:”36481″,”video”:””,”imagePlaceholder”:””,”imagePlaceholderId”:””,”title”:”Some breast cancers lack two key hormone receptors as well as the HER2 receptor. What is this type of breast cancer called?”,”desc”:”In triple-negative breast cancer, the cancer cells don\u2019t have estrogen, progesterone, or HER2 receptors. As a result, this kind of cancer is very difficult to treat. CSHL Professor John Moses and Assistant Professor Michael...

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Cancer lab makes surprise discoveries in heart disease

Margaret Osborne — Wed, 30 Nov 2022 12:30:45 +0000

Sometimes science can lead to unexpected discoveries in unexpected places. That’s what ��ϳԹ��Դ (CSHL) Professor David Spector experienced this year. For nearly four decades, Spector has been researching cancer—the United States’ second-leading cause of death. But this year, he found himself studying the first—heart disease. Spector’s research at CSHL focuses on how...

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Can cancer be treated by changing its cells?

Communications Department — Mon, 11 Apr 2022 11:30:50 +0000

In 2017, Karen Kostroff, a renowned oncology surgeon at Northwell Health in the New York Metropolitan area, added a new talking point to her standard conversation with breast cancer patients facing tumor removal surgery. These conversations are never easy, because a cancer diagnosis is devastating news. But the new topic seemed to give her patients...

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Paving a path to triple-negative breast cancer treatment

Daniel Dunaief — Tue, 29 Mar 2022 12:00:24 +0000

It’s the cancer version of “mini me.” ��ϳԹ��Դ (CSHL) Professor David Spector, among others, has developed organoids, which are miniature, three-dimensional copies of cancers. Organoids can be derived from cancer or healthy cells. They allow scientists to study the basic biology of particular types of tumors, then to test specific drugs on...

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Regulatory RNAs promote breast cancer metastasis

Jennifer Michalowski — Tue, 22 Dec 2020 10:00:29 +0000

��ϳԹ��Դ (CSHL) scientists have discovered a gene-regulating snippet of RNA that may contribute to the spread of many breast cancers. In animal experiments, the researchers could reduce the growth of metastatic tumors with a molecule designed to target that RNA and trigger its destruction. The same strategy, they say, could be used...

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One experiment: Organoids as living laboratories

Luis Sandoval — Fri, 30 Oct 2020 18:45:43 +0000

Organoids are tiny balls of cells that look and behave like the organs or tumors from which they were taken. ��ϳԹ��Դ (CSHL) Cancer Center Director David Tuveson pioneered their use in pancreatic cancer research. Scientists use organoids to study how cancers grow, develop, metastasize, and can be detected and treated. At the...

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Women’s coalition donates $100k to breast cancer research

Jill Stone — Thu, 06 Dec 2018 15:12:39 +0000

Manhasset Women’s Coalition Against Breast Cancer (MWCABC) has donated $100,000 to support breast cancer research at ��ϳԹ��Դ. The donation supports the research of postdoctoral fellow Dr. Sonam Bhatia whose work focuses on developing new therapeutic targets for breast cancer using organoid technology. Members of the MWCABC’s Research Committee recently visited the Laboratory...

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Undergrad symposium highlights lessons in the lab

Sara Roncero-Menendez — Mon, 20 Aug 2018 20:22:41 +0000

The 2018 Undergraduate Research Program (URP) culminated in an end-of-the-summer symposium on August 9–10, with students presenting the results of their intensive 10-week research projects. Twenty students from universities all around the globe worked in the many labs across campus under the mentorship of ��ϳԹ��Դ (CSHL) researchers in the fields of cancer...

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What does it mean to be an URP?

Communications Department — Mon, 20 Aug 2018 15:33:36 +0000

A quick chat with Matheo Moralis and Professor David Spector, Director of Research, reveals how much the work of our undergraduate researchers mean to CSHL. Hint: A whole lot.

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Portrait of a Neuroscience Powerhouse

Peter Tarr — Fri, 27 Apr 2018 16:07:30 +0000

At noon every Tuesday from September through June, scenes from a revolution in neuroscience are playing out at ��ϳԹ��Դ. Week after week, over 100 scientists cram themselves into a ground-floor meeting room in the Beckman Laboratory. It’s standing-room only as everyone in the Neuroscience Program settles in to hear details of the...

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David Spector is named ASCB Fellow

Sara Roncero-Menendez — Mon, 11 Dec 2017 16:14:06 +0000

David L. Spector, Ph.D., a professor at ��ϳԹ��Դ (CSHL) and the Laboratory’s Director of Research, was named a fellow of The American Society for Cell Biology (ASCB). “This is a great honor, as the ASCB is the premiere society promoting scientific research, diversity in science, and advocating for public policy that impacts...

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Breast cancer’s dark matter

Public Affairs Administrator — Fri, 21 Jul 2017 20:40:06 +0000

Senior Fellow Sarah Diermeier, Ph.D., talks about breast cancer and how she and Spector Lab are exploring the “dark matter of the genome” to find new ways to stop it.

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CSHL to lead international team developing next-generation organoid cancer research

Peter Tarr — Thu, 11 May 2017 09:00:26 +0000

��ϳԹ��Դ (CSHL) has been awarded a research subcontract by Leidos Biomedical Research to lead a Cancer Model Development Center

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Base Pairs Episode 9: Dark matter of the genome, part 2

Communications Department — Sat, 15 Apr 2017 16:48:40 +0000

Base Pairs podcast - We question the mythos that is “junk DNA” and explore how and why scientists are becoming enthralled by the mysterious non-coding portions of the genome.

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Cold Spring Harbor HS football player donates CSHL’s breast cancer research

Jill Stone — Tue, 13 Dec 2016 20:21:47 +0000

Eli Gordon, kicker for the Cold Spring Harbor Seahawks Varsity Football Team, presented a check today for $1,000.00 for breast cancer research, as part of his “Kick Cancer” fundraising initiative, to Dr. David Spector, Director of Research and Professor at Cold Spring Harbor Labs. Gordon pledged $25 for every extra point he made this season;...

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David L. Spector Archives | ���ϳԹ���Դ