cancer genetics Archives | ��ϳԹ��Դ

The Unspoken Truth: A Dialogue on Prostate Cancer

Communications Department — Tue, 30 Jun 2026 16:00:01 +0000

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Why does cancer keep growing?

Jen A. Miller — Fri, 10 Oct 2025 11:30:24 +0000

Why do cancer cells keep dividing over and over? The answer can be found in fundamental biology breakthroughs of the late 20th century. In 1982, ��ϳԹ��Դ (CSHL) geneticist Michael Wigler helped identify the first known human oncogenes. When mutated, these genes produce an excess of proteins that cause uncontrolled cell growth. Soon...

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Pancakes may never taste this good again

Communications Department — Thu, 15 May 2025 11:30:25 +0000

round seven years ago, I was a super eager undergraduate student studying biochemistry and starting my very first research internship at the Spanish Center for Biotechnology. I did not know much about how cancer worked, how it arises, or what makes it grow. All I knew was that I wanted to make an impact. I...

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Lessons of the past, leaders of tomorrow

Emma Courtney — Mon, 21 Apr 2025 11:30:31 +0000

BRCA1, the first gene associated with hereditary breast cancer." data-description="" />From March 26–29, 2025, ��ϳԹ��Դ’s Center for Humanities & History of Modern Biology, in collaboration with the CSHL Meetings & Courses Program, hosted Cancer Genetics: History & Consequences. The extraordinary international gathering brought together the field’s pioneers with today’s leading innovators and future trailblazers. Over four days, attendees were immersed in a...

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Cancer Genetics: History & Consequences

Communications Department — Thu, 17 Apr 2025 11:30:04 +0000

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At the Lab Season 1 Research Rewind: Cancer

Communications Department — Tue, 08 Oct 2024 11:30:26 +0000

Miss an episode or two from the first season of our new podcast? Over the next few weeks, we’ll revisit each in a series we call ‘Research Rewind.’ This week At the Lab, you’ll hear all about our cutting-edge cancer research from CSHL scientists Semir Beyaz, Mikala Egeblad, Alea Mills, John Moses, and Christopher Vakoc....

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At the Lab Episode 16: Bats!

Communications Department — Tue, 23 Jul 2024 16:00:17 +0000

Sometimes one word says it all. Case in point: Bats. This week At the Lab, we hear from CSHL Professor W. Richard McCombie about the curious origin story behind a recent headline-making study his lab conducted with Professor Adam Siepel, postdoc Armin Scheben, and the American Museum of Natural History.

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Pancreatic cancer’s cellular amnesia

Margaret Osborne — Mon, 17 Jun 2024 09:00:13 +0000

Things aren’t always as they seem. Take pancreatic cancer, for example. In up to one in 10 cases, researchers have documented a peculiar characteristic. Some of the pancreatic cells appear to have lost their identity. It’s as if they forget what they are. Former ��ϳԹ��Դ (CSHL) postdoc Diogo Maia-Silva, now at Massachusetts...

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Pancreatic cancer hijacks a brain-building protein

Nick Wurm — Wed, 14 Feb 2024 12:30:53 +0000

Scientists at ��ϳԹ��Դ (CSHL) and the University of California, Davis have reached a new breakthrough in pancreatic cancer research—eight years in the making. It could help slow the disease’s deadly spread. In 2017, as a postdoc in CSHL’s Tuveson lab, Chang-il Hwang and collaborators from the Vakoc lab uncovered a protein essential...

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Test your breast cancer awareness

Communications Department — Wed, 18 Oct 2023 11:30:33 +0000

{“questions”:{“equ3q”:{“id”:”equ3q”,”mediaType”:”image”,”answerType”:”text”,”imageCredit”:””,”image”:”https:\/\/www.cshl.edu\/wp-content\/uploads\/2019\/12\/novel-therapy-target-triple-negative-breast-cancer.jpg”,”imageId”:”36481″,”video”:””,”imagePlaceholder”:””,”imagePlaceholderId”:””,”title”:”Some breast cancers lack two key hormone receptors as well as the HER2 receptor. What is this type of breast cancer called?”,”desc”:”In triple-negative breast cancer, the cancer cells don\u2019t have estrogen, progesterone, or HER2 receptors. As a result, this kind of cancer is very difficult to treat. CSHL Professor John Moses and Assistant Professor Michael...

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Holy immunity! Bat genes key against COVID, cancer

Nick Wurm — Mon, 16 Oct 2023 11:30:39 +0000

Artibeus jamaicensis, the Jamaican fruit bat (seen here), and Pteronotus mesoamericanus, the Mesoamerican mustached bat." data-description="" />Bats have acquired remarkable traits throughout their evolution. They’re the only mammals that can fly, and they live much longer than other animals their size. But perhaps most impressive is their robust immune system. It protects bats from viruses that wreak havoc in humans, like COVID-19 or Ebola. It also keeps bats relatively cancer-free. How?...

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Metastatic breast cancer’s Trojan horse

Nick Wurm — Wed, 26 Jul 2023 11:30:34 +0000

Lymph nodes are one of the body’s first lines of defense against disease. Immune cells are dispatched from these biological police stations to fight off intruders. But somehow, lymph nodes are also the first stop for most metastatic cancers. “It’s paradoxical,” ��ϳԹ��Դ (CSHL) Assistant Professor Semir Beyaz says. “The cancer goes right...

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Unlocking cancer’s ancestry

Nick Wurm — Tue, 27 Dec 2022 12:30:39 +0000

RAIDS (Robust Ancestry Inference using Data Synthesis) could help fill these knowledge gaps. Image: © Tex vector – stock.adobe.com" data-description="" />Could knowing where your ancestors came from be the key to better cancer treatments? Maybe, but where would that key fit? How can we trace cancer’s ancestral roots to modern-day solutions? For ��ϳԹ��Դ (CSHL) Research Professor Alexander Krasnitz, the answers may lie deep within vast databases and hospital archives containing hundreds of...

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Breaking the chain that culminates in cancer

Luis Sandoval — Wed, 01 Dec 2021 14:00:04 +0000

In a line of dominos, if you take out a single piece, the last one will never fall. Similarly, a lot of pieces have to line up and be pushed at the same time in a cell to result in cancer. Twenty-two years ago, ��ϳԹ��Դ (CSHL) Professor Alea Mills discovered the protein...

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When cancer cells “put all their eggs in one basket”

Jasmine Lee — Thu, 27 May 2021 12:00:35 +0000

Normal cells usually have multiple solutions for fixing problems. For example, when DNA becomes damaged, healthy white blood cells can use several different strategies to make repairs. But cancer cells may “put all their eggs in one basket,” getting rid of all backup plans and depending on just one pathway to mend their DNA. Cold...

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One experiment: Organoids as living laboratories

Luis Sandoval — Fri, 30 Oct 2020 18:45:43 +0000

Organoids are tiny balls of cells that look and behave like the organs or tumors from which they were taken. ��ϳԹ��Դ (CSHL) Cancer Center Director David Tuveson pioneered their use in pancreatic cancer research. Scientists use organoids to study how cancers grow, develop, metastasize, and can be detected and treated. At the...

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How two CSHL programs adapted during the COVID-19 pandemic

Sara Roncero-Menendez — Thu, 16 Jul 2020 20:48:04 +0000

On July 8, ��ϳԹ��Դ (CSHL) Associate Professor Mikala Egeblad and CSHL DNA Learning Center Executive Director David Micklos presented an overview of their research to over 400 digital participants as part of the “Life Science Across the Globe” seminar series. CSHL is one of six sister institutions giving both a science talk...

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How breast cancer cells sneak past local immune defenses

Brian Stallard — Wed, 15 Jul 2020 14:00:17 +0000

��ϳԹ��Դ (CSHL) Associate Professor Mikala Egeblad and her colleagues describe a newly understood way by which breast cancer cells sabotage a key player in the body’s immune system. That key player provides local immune surveillance by activating killer T-cells, but if it cannot mature and do its job, breast cancer cells can...

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Blocking cholesterol storage could stop growth of pancreatic tumors

Jennifer Michalowski — Tue, 07 Jul 2020 14:00:04 +0000

Scientists at ��ϳԹ��Դ (CSHL) have found that they can stop the growth of pancreatic cancer cells by interfering with the way the cells store cholesterol. Their findings in mice and lab-grown pancreas models point toward a new strategy for treating the deadly disease. The study, reported in the Journal of Experimental Medicine,...

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Why pancreatic ductal adenocarcinoma is so lethal

Communications Department — Tue, 19 May 2020 13:28:31 +0000

Pancreatic ductal adenocarcinoma (PDA) is a deadly cancer, killing patients within a year. CSHL Professor Christopher Vakoc and his former postdoc Timothy Somerville discovered how pancreatic cells lose their identity, acquire a deadly new identity, and recruit nearby cells to help them grow, promote inflammation, and invade nearby tissues. This understanding could lead to new...

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cancer genetics Archives | ���ϳԹ���Դ