Cancer Genetics Program Archives | ��ϳԹ��Դ

Zhen Zhao

Marc Persad — Wed, 27 Sep 2023 14:28:56 +0000

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New method to determine before surgery which prostate tumors pose a lethal threat

Peter Tarr — Fri, 01 Dec 2017 16:38:11 +0000

Prostate cancer is common and largely nonlethal. But for some 21,000 men—a small percentage of the total, but a nonetheless substantial number—the disease is fatal. For earlier and more accurate detection, the Krasnitz and Wigler labs have devised a new method to analyze tumor biopsies to identify the most lethal forms of prostate cancer.

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Next-gen cancer test

Peter Tarr — Fri, 24 Nov 2017 17:00:40 +0000

Knowing that cancers become lethal when they spread, investigators at ��ϳԹ��Դ (CSHL) seek a way of detecting tumors much earlier than now possible—when they’re more likely to be curable. Fleshing out an idea Professor Michael Wigler had years ago—before there was technology to act on it—research led by Associate Professor Alexander Krasnitz...

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What a real-life science test looks like

Andrea Alfano — Fri, 24 Mar 2017 18:56:29 +0000

By revealing evidence that contradicts the rationale for a new cancer drug, a pair of student scientists learns firsthand that when you do science, you must ultimately treat everything as a hypothesis. t first, Ann Lin and Chris Giuliano thought, “we must have done something wrong.” The two Stony Brook undergrads are cancer researchers in...

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Relationship between incorrect chromosome number and cancer is reassessed after surprising experiments

Peter Tarr — Thu, 12 Jan 2017 12:00:00 +0000

Copy number variation is a hallmark of most cancers, and it often serves as a driver of cell proliferation. Surprisingly, new research from the Sheltzer lab suggests that an extra chromosome alone is not enough to initially spur tumor growth. Rather, prolonged changes in chromosome number lead to genetic instability that ultimately causes uncontrolled cell proliferation.

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A theoretical physicist’s approach to breast cancer

Andrea Alfano — Fri, 21 Oct 2016 20:56:11 +0000

Ideas borrowed from physics could help scientists improve treatments for breast cancer. Associate Professor Mickey Atwal explains in this guest blog post. reast cancer is more than a group of rogue cells. They exist within an intricate battleground inside patients, which scientists call the “microenvironment.” This consists not only of the wayward tumor cells themselves but also...

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CSHL scientists Bo Li and Je Lee win HFSP Research Grant awards

Communications Department — Tue, 12 Apr 2016 15:03:41 +0000

Cold Spring Harbor, NY — Two scientists, both leaders of research labs at ��ϳԹ��Դ (CSHL), are among 25 teams that have won Human Frontier Science Program (HFSP) Research Program Grants for 2016. The awards were announced by the International Human Frontier Science Program Organization (HFSPO), based in Strasbourg, France. The two CSHL...

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Introducing the mighty Panoramix–defender of genomes!

Jennifer Michalowski — Thu, 15 Oct 2015 14:00:58 +0000

Protein named for comic book hero is no joke: it guides gene-silencing machinery to sites of havoc-causing transposons Cold Spring Harbor, NY — Organisms from bacteria to humans must defend themselves against parasitic genetic elements called transposons, and the stakes are high. These pieces of DNA, which disrupt genes by jumping around in the genome, can...

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CSHL Fellow wins 2015 NIH Early Independence Award for cancer research

Dagnia Zeidlickis — Tue, 06 Oct 2015 14:26:14 +0000

Cold Spring Harbor, NY — ��ϳԹ��Դ (CSHL) today congratulates CSHL Fellow Jason Sheltzer, Ph.D. on receiving the 2015 Early Independence Award from the National Institutes of Health (NIH) High Risk, High Reward Research Program. With a Ph.D. in Biology from MIT, Sheltzer joined CSHL in August 2015 to pursue cancer research. Sheltzer,...

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Scientists sequence genome of worm that can regrow body parts, seek stem cell insights

Communications Department — Mon, 21 Sep 2015 15:00:08 +0000

M. lignano and diagrammatic key. The tiny worm intrigues scientists because it can regenerate almost its whole body following an injury. Hence, their effort to sequence its genome." data-description="" />Worm’s genome could lead to better understanding of its regenerative prowess and advance stem cell biology Cold Spring Harbor, NY — Tourists spending a recuperative holiday on the Italian coast may be envious of the regenerative abilities of locally found flatworm Macrostomum lignano. Named for its discovery near the Italian beach town of Lignano Sabbiadoro,...

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Mathematical ‘Gingko trees’ reveal mutations in single cells that characterize diseases

Communications Department — Fri, 04 Sep 2015 19:58:10 +0000

The Schatz lab, in collaboration with the Wigler and Atwal labs, has developed a new interactive, open-source analysis program called Gingko that can be used to reduce the uncertainty of single-cell analysis and visualize patterns in copy number mutations across populations of cells.

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12th annual LI2DAY Walk raises over $400,000

Communications Department — Tue, 01 Sep 2015 15:01:55 +0000

Cold Spring Harbor, NY — ��ϳԹ��Դ (CSHL) is among 17 Long Island-based organizations to receive funding from the 2015 Long Island 2 Day Walk to Fight Breast Cancer. This year’s walk raised over $400,000 for outreach services, educational programs and research to benefit women and their families affected by breast and other cancers...

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The biggest beast in the Big Data forest? One field’s astonishing growth is, well, ‘genomical’!

Peter Tarr — Mon, 06 Jul 2015 15:40:03 +0000

Cold Spring Harbor, NY — Who’s about to become the biggest beast in the Big Data forest? A group of math and computing experts have arrived at what they say is a clear answer. It’s not YouTube or Twitter, social media sites that gobble up awesome quantities of bandwidth and generate hard-to-grasp numbers of electronic...

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Scientists show the mammary gland ‘remembers’ prior pregnancy, spurring milk production

Peter Tarr — Thu, 07 May 2015 12:00:24 +0000

Camila dos Santos, as a postdoctoral researcher in the Hannon lab, identified the epigenetic changes that occur after pregnancy in the mouse mammary gland. The work offers insight into how pregnancy early in life may protect against breast cancer later.

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Tumor cells that mimic blood vessels could help breast cancer spread to other sites

Communications Department — Wed, 08 Apr 2015 13:00:01 +0000

The Hannon lab developed a novel mouse model for breast cancer heterogeneity and used it to identify clones that were highly metastatic. The team found that these cells formed tube-like structures that mimic blood vessels, and identified two genes that drive vascular mimicry, which is likely promote growth of the primary tumor as well as metastasis.

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��ϳԹ��Դ engages Hairpin Technologies Inc. to license its short hairpin RNA (shRNA) technology

Communications Department — Tue, 31 Mar 2015 08:00:08 +0000

Cold Spring Harbor, NY — ��ϳԹ��Դ (CSHL) has engaged Hairpin Technologies Inc. to expand the commercial distribution and research use of short hairpin RNA (shRNA) technology. Hairpin Technologies will serve as CSHL’s exclusive agent for negotiating and executing new license agreements with potential licensees of CSHL’s U.S. and international patents covering the shRNA...

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CSHL quantitative biologist Michael Schatz awarded 2015 Sloan Foundation Research Fellowship

Peter Tarr — Fri, 20 Feb 2015 15:40:17 +0000

Cold Spring Harbor, NY — Associate Professor Michael Schatz of ��ϳԹ��Դ (CSHL) will receive a 2015 Alfred P. Sloan Foundation Research Fellowship. This prestigious research award has been issued since 1955. Schatz is one of 126 outstanding early-career scientists from the U.S. and Canada recognized by the Foundation this year. Past honorees...

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Harnessing data from nature’s great evolutionary experiment

Communications Department — Wed, 21 Jan 2015 15:51:41 +0000

Scientists develop a computational method to estimate the importance of each letter in the human genome Cold Spring Harbor, NY — There are 3 billion letters in the human genome, and scientists have endlessly debated how many of them serve a functional purpose. There are those letters that encode genes, our hereditary information, and those...

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CSHL thanks the Don Monti Memorial Research Foundation for $500,000 contribution in support of leading-edge cancer research

Dagnia Zeidlickis — Tue, 05 May 2009 15:48:59 +0000

Cold Spring Harbor, NY — A growing partnership between ��ϳԹ��Դ (CSHL) and the Don Monti Memorial Research Foundation has been significantly strengthened. The Foundation, based in Cold Spring Harbor, New York, has donated $500,000 to CSHL’s cancer genetics research program. The funds will support research that is the basis for the development of...

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Cancer Genetics Program Archives | ���ϳԹ���Դ