Bo Li Archives | ��ϳԹ��Դ

The CSHL School of Biological Sciences’ class of 2025

Communications Department — Mon, 05 May 2025 18:00:58 +0000

The ��ϳԹ��Դ (CSHL) School of Biological Sciences (SBS) takes an innovative approach to advanced science education. Graduates of the doctoral program go on to pursue a wide range of careers. On May 4, the SBS awarded nine graduates Ph.D. degrees. Here, the class of 2025 reflects on their time and experiences at...

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A perception quiz to blow your mind

Communications Department — Wed, 26 Mar 2025 11:30:40 +0000

{“questions”:{“7fxb8”:{“id”:”7fxb8″,”mediaType”:”image”,”answerType”:”text”,”imageCredit”:”\u00a9 mh.desing – stock.adobe.com”,”image”:”https:\/\/www.cshl.edu\/wp-content\/uploads\/2024\/08\/mosaic_face_diversity.jpg”,”imageId”:”71410″,”video”:””,”imagePlaceholder”:””,”imagePlaceholderId”:””,”title”:”How long, on average, does it take for the human brain to perceive and respond to visual stimuli?”,”desc”:”Fruit flies can respond to visual stimuli in less than five milliseconds. Our average reaction time is about 200 milliseconds\u2014i.e., one-fifth of a second. Interestingly, this is also about the amount of time that usually...

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At the Lab Season 1 Research Rewind: Neuroscience

Communications Department — Tue, 15 Oct 2024 11:30:25 +0000

Trying to remember that one thing that one CSHL scientist said about the brain that one time? Jog your memory and catch up on what you might have missed in our latest Research Rewind. This week At the Lab, you’ll hear all about our innovative neuroscience research from CSHL scientists Arkarup Banerjee, Benjamin Cowley, Hiro...

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At the Lab Episode 20: Cleanup on IL-6

Communications Department — Tue, 20 Aug 2024 11:30:30 +0000

“The power of mind” has long been a calling card of herbalists and mystics of all stripes. Most often, it should be taken with a big grain of salt. This week At the Lab, CSHL Professor Bo Li discusses new scientific research that could bring us closer to understanding the true connections between mind and...

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How to stop cancer cachexia? Start at the top

Nick Wurm — Mon, 08 Jul 2024 11:30:11 +0000

Cancer is insidious. Throughout tumor progression, the disease hijacks otherwise healthy biological processes—like the body’s immune response—to grow and spread. When tumors elevate levels of an immune system molecule called Interleukin-6 (IL-6), it can cause severe brain dysfunction. In about 50%-80% of cancer patients, this leads to a lethal wasting disease called cachexia. “It’s a...

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Bite into this diet and disease quiz

Communications Department — Wed, 05 Jul 2023 11:30:26 +0000

{“questions”:{“fmpo8”:{“id”:”fmpo8″,”mediaType”:”image”,”answerType”:”text”,”imageCredit”:””,”image”:”https:\/\/www.cshl.edu\/wp-content\/uploads\/2021\/09\/normal-mouse-small-intestine.jpg”,”imageId”:”56101″,”video”:””,”imagePlaceholder”:””,”imagePlaceholderId”:””,”title”:”Which one of these diets makes it harder for the immune system to recognize and attack colorectal cancer in mice?”,”desc”:”CSHL Assistant Professor Semir Beyaz has found that a high-fat diet masks intestinal cancer in mice by suppressing a cell tag called MHC-II. When these tags were reduced in mice, their immune systems didn\u2019t recognize potentially...

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The CSHL School of Biological Sciences’ class of 2023

Communications Department — Sun, 07 May 2023 22:01:03 +0000

The ��ϳԹ��Դ (CSHL) School of Biological Sciences (SBS) takes an innovative approach to advanced science education. Graduates of the doctoral program go on to pursue diverse careers. This year, the SBS awarded 11 Ph.D. degrees. Here, members of the class of 2023 share memories and experiences from their time at CSHL. Lyndsey...

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Danger or pleasure? How we learn to tell the difference

Margaret Osborne — Wed, 05 Apr 2023 15:00:22 +0000

Deep within our brain’s temporal lobes, two almond-shaped cell masses help keep us alive. This tiny region, called the amygdala, assists with a variety of brain activities. It helps us learn and remember. It triggers our fight-or-flight response. It even promotes the release of a feel-good chemical called dopamine. Scientists have learned all this by...

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Got junk food on the brain? These cells may be to blame

Jennifer Michalowski — Thu, 20 Oct 2022 15:00:09 +0000

A region of the brain called the amygdala is responsible for powerful emotions like fear. Now, researchers have found the amygdala may also be to blame for overeating. ��ϳԹ��Դ (CSHL) Professor Bo Li has discovered a group of neurons in the amygdala that drives mice to eat fatty or sugary foods—even when...

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Fine-tuning motivation in the brain

Luis Sandoval — Thu, 09 Dec 2021 16:00:38 +0000

Fezf2 and are connected to and activate other neurons, which are stained green in this image of a mouse brain. Image: Li lab" data-description="" />A characteristic of depression is a lack of motivation. ��ϳԹ��Դ (CSHL) Professor Bo Li, in collaboration with CSHL Adjunct Professor Z. Josh Huang, discovered a group of neurons in the mouse brain that influences the animal’s motivation to perform tasks for rewards. Dialing up the activity of these neurons makes a mouse...

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Mammalian motivation circuits: Maybe they’re born with it

Jasmine Lee — Mon, 18 Oct 2021 15:00:12 +0000

Are we born to fear punishment or crave rewards? Or do those capacities evolve with experience? ��ϳԹ��Դ (CSHL) Professor Bo Li and his lab found that mice have pre-programmed circuits that process “positive” and “negative” stimuli. These neurons are found in the mouse’s amygdala, a section of the brain that deals with...

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NIH BRAIN Initiative invests $9.7 million in CSHL scientists

Luis Sandoval — Tue, 29 Dec 2020 13:30:45 +0000

The National Institute of Health (NIH) Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative awarded a total of $9.7 million in new grants to ��ϳԹ��Դ (CSHL) professors, a senior fellow, and a visiting scientist. Started in 2013, the BRAIN Initiative funds innovative neuroscience projects. The goal is to better treat, prevent, and...

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Bo Li and Richard Sever present at “Life Science Across the Globe”

Sara Roncero-Menendez — Wed, 18 Nov 2020 15:00:23 +0000

On October 28th, ��ϳԹ��Դ (CSHL) participated in the weekly seminar series “Life Science Across the Globe”. CSHL, along with five other institutions around the world, presented both science and science culture talks to a global audience via video conference. CSHL Professor and HHMI Investigator Leemor Joshua-Tor welcomed the digital attendees and introduced...

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How does the brain process fear?

Jennifer Michalowski — Tue, 03 Nov 2020 17:45:33 +0000

When a frightful creature startles you, your brain may activate its fear-processing circuitry, sending your heart racing to help you escape the threat. It’s also the job of the brain’s fear-processing circuits to help you learn from experience to recognize which situations are truly dangerous and to respond appropriately—so if the scare comes from a...

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The motivation center of the mouse brain in 3D

Marc Persad — Tue, 15 Sep 2020 15:06:27 +0000

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Reward and punishment take similar paths in the mouse brain

Jennifer Michalowski — Tue, 15 Sep 2020 15:00:21 +0000

Allen Brain Atlas, Mouse Brain Connectivity Atlas, Dorsal Striatum" data-description="" />��ϳԹ��Դ (CSHL) scientists have discovered neurons in the mouse brain that help an animal learn to avoid negative experiences. The cells reside in a part of the brain involved in regulating the motivations that influence behavior. Previously, this part of the brain, known as the striosome, was thought to be dedicated to...

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How the brain balances pleasure and pain

Jennifer Michalowski — Tue, 31 Dec 2019 16:00:47 +0000

As our brains take in information about the world and use it to steer our actions, two key principles guide our choices: seek pleasure and avoid pain. Researchers at ��ϳԹ��Դ (CSHL) have zeroed in on an information-processing hub in the brains of mice to discover how neurons there divide the labor to...

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CSHL postdocs receive NARSAD Young Investigator Grants

Communications Department — Wed, 30 Oct 2019 17:37:19 +0000

��ϳԹ��Դ’s Roman Dvorkin, Ph.D., and Xian Zhang, Ph.D., were recently selected by the Brain and Behavior Research Foundation to each receive a 2019 NARSAD Young Investigator Grant (pdf). The grants, which support young scientists conducting neurobiological and psychiatric research, provide promising investigators with up to $70,000 over two years to help them...

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Interview with a neuroscientist

Charlotte Hu — Fri, 31 May 2019 13:18:26 +0000

Comprised of a M.C. Escher-esque network of pathways, the brain is a maze of chaotic proportions. In its full-functioning glory, the brain helps us move, think, dream, and create. It’s a beautiful marvel of evolution that coordinates and translates messages from cells into emotions, memories, and actions. But what happens in the brain when its...

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Brain, interrupted

Charlotte Hu — Fri, 31 May 2019 13:09:13 +0000

{“questions”:{“nk5k0”:{“id”:”nk5k0″,”mediaType”:”image”,”answerType”:”text”,”imageCredit”:”Edvard Munch ‘The Scream'”,”image”:”https:\/\/www.cshl.edu\/wp-content\/uploads\/2019\/05\/The_Scream-Edvard-Munch.jpg”,”imageId”:”28655″,”video”:””,”imagePlaceholder”:””,”imagePlaceholderId”:””,”title”:”In a normal brain, we have a programmed response to a threatening situation. In a brain riddled with anxiety, that normal program is overriden. These reactionary responses are processed in a part of the brain that codes emotions, called the:”,”desc”:”The amygdala is the brain\u2019s seat of emotion, otherwise known as the alarm...

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Bo Li Archives | ���ϳԹ���Դ