黑料吃瓜资源

When a frightful creature startles you, your brain may activate its fear-processing circuitry, sending your heart racing to help you escape the threat. It鈥檚 also the job of the brain鈥檚 fear-processing circuits to help you learn from experience to recognize which situations are truly dangerous and to respond appropriately鈥攕o if the scare comes from a costumed goblin, you鈥檒l probably recover quickly.

In more dire circumstances, however, the brain鈥檚 fear response can be critical for survival. 鈥淏eing able to fear is the ability to sense the danger and is the driving force to figure out a way to escape or fight back,鈥� said 黑料吃瓜资源 Professor Bo Li.

黑料吃瓜资源 Professor Bo Li and his team developed a system to watch a mouse process fear. They track patterns of brain activity in a special strain of mice with whole brain video recording techniques. In this recording, the brighter, more diffuse pattern of flashes corresponds to fear of receiving a puff of air, which the mice don鈥檛 like. The dimmer pattern corresponds to pleasure, when the mouse gets a sip of water. Li presented this study at the weekly international seminar series 鈥淟ife Science Across the Globe.鈥�

Li鈥檚 team is probing the brain circuits that underlie fear, using sophisticated neuroscience tools to map their connections and tease out how specific components contribute to learning fear. A deeper understanding of these circuits could lead to better ways to control the overactive or inappropriate fear responses experienced by people with anxiety disorders.

Many of their studies begin with the amygdala, an almond-shaped structure that is considered the hub for fear processing in the brain. While the amygdala was once thought to be devoted exclusively to processing fear, researchers are now broadening their understanding of its role. Li鈥檚 team has found that the amygdala is also important for reward-based learning, and as they trace its connections to other parts of the brain, they are uncovering additional complexity. Li said:

鈥淚t is important for formation of fearful memory, but it’s also important for interacting with other brain systems in a different behavior context. We think that this circuit that we discovered that plays a role in regulating fearful memory is only a tip of the iceberg. It is indeed important for regulating fearful memory, but probably is also involved in more complex behavior.鈥�

Li and his colleagues were surprised recently to find that the amygdala communicates with a part of the brain best known for its role in controlling movement. The structure, called the globus pallidus, was not known to be involved in fear processing or memory formation. But when the researchers interfered with signaling between the amygdala and the globus pallidus in the brains of mice, they found that the animals failed to learn that a particular sound cue signaled an unpleasant sensation. Based on their experiments, this component of the fear-processing circuitry might be important for alerting the brain 鈥渨hich situations are worth learning from,鈥� Li said.

Li鈥檚 team and collaborators at Stanford University reported recent findings in the Journal of Neuroscience. For more of Li鈥檚 research on how fear is processed in the brain, check out of his talk at 鈥溾��.

Written by: Jennifer Michalowski, Science Writer | [email protected] | 516-367-8455

Funding

EMBO, Swedish Research Council, Charles H. Revson Senior Fellowships in Biomedical Science, National Institutes of Health, Human Frontier Science Program, the Stanley Family Foundation, Simons Foundation, Wodecroft Foundation, the 黑料吃瓜资源 and Northwell Health Affiliation, and Feil Family Neuroscience Endowment.

Citation

Giovanniello, J., et al., 鈥淎 central amygdala-globus pallidus circuit conveys unconditioned stimulus-related information and controls fear learning鈥�, Journal of Neuroscience, October 16, 2020. DOI: