Zihua Wang
Research Assistant Professor
Cancer Center Member
Ph.D., National University of Singapore, 2008
[email protected] | 516-367-5259
As a molecular biologist, I am fascinated by the new technologies in molecular genetic studies. My research is aimed at developing new technologies and applying them mainly to cancer studies, such as early detection, prognosis, and measuring minimal residual disease.
Wang has developed, optimized, and finalized several bench technologies for cancer tumor profile studies and fetal genotyping. To rapidly and cost-effectively evaluate large numbers of samples, all of these techniques are based on next-generation sequencing platforms. Working with the Wigler lab, Wang’s research focused on the detection of rare point mutations, indels, copy number variations, and the length variants of microsatellites. By achieving high accuracy, specificity, and sensitivity with these technologies, Wang’s group has confirmed their applications in measuring minimal residual disease and prognosis of cancer. In collaboration with clinical partners, the applications of early detection of cancer and embryo genotyping by cell-free DNA sequencing in spent culture mediums are being tested. Moreover, most of these technologies are being translated into medically actionable tests.
All Publications
7 Jul 2023 | Cancer Discovery | 13(7):1678-1695
Wan, Ledong; Lin, Kuan-Ting; Rahman, Mohammad; Ishigami, Yuma; Wang, Zhikai; Jensen, Mads; Wilkinson, John; Park, Youngkyu; Tuveson, David; Krainer, Adrian;
12 Sep 2022 | Nucleic Acids Research (NAR) | :gkac723
Wang, Zihua; Moffitt, Andrea; Andrews, Peter; Wigler, Michael; Levy, Dan;
1 Sep 2021 | Communications Biology | 4(1):1026
Yoon, Seungtai; Munoz, Adriana; Yamrom, Boris; Lee, Yoon-Ha; Andrews, Peter; Marks, Steven; Wang, Zihua; Reeves, Catherine; Winterkorn, Lara; Krieger, Abba; Buja, Andreas; Pradhan, Kith; Ronemus, Michael; Baldwin, Kristin; Levy, Dan; Wigler, Michael; Iossifov, Ivan;
2 Aug 2021 | Developmental Cell
Lukow, Devon; Sausville, Erin; Suri, Pavit; Chunduri, Narendra; Wieland, Angela; Leu, Justin; Smith, Joan; Girish, Vishruth; Kumar, Ankith; Kendall, Jude; Wang, Zihua; Storchova, Zuzana; Sheltzer, Jason;
30 Jun 2021 | Journal of Integrative Neuroscience | 20(2):393-397
Zhang, Qin-Qin; Wang, Zi-Hua; Zhang, Jun-Shi; Guo, Jun-Nan; Lin, Xu-Hong; An, Lei;
24 Feb 2020 | Developmental Cell | 52(4):413-428
Vasudevan, A; Baruah, P; Smith, J; Wang, Z; Sayles, N; Andrews, P; Kendall, J; Leu, J; Chunduri, N; Levy, D; Wigler, M; Storchova, Z; Sheltzer, J;
21 Feb 2020 | Nucleic Acids Research (NAR) | 48(7):e40
Moffitt, A; Spector, M; Andrews, P; Kendall, J; Alexander, J; Stepansky, A; Ma, B; Kolitz, J; Chiorazzi, N; Allen, S; Krasnitz, A; Wigler, M; Levy, D; Wang, Z;
23 Dec 2019 | Nature Medicine | 26(1):143-150
Breuss, M; Antaki, D; George, R; Kleiber, M; James, K; Ball, L; Hong, O; Mitra, I; Yang, X; Wirth, S; Gu, J; Garcia, C; Gujral, M; Brandler, W; Musaev, D; Nguyen, A; McEvoy-Venneri, J; Knox, R; Sticca, E; Botello, M; Uribe Fenner, J; Perez, M; Arranz, M; Moffitt, A; Wang, Z; Hervas, A; Devinsky, O; Gymrek, M; Sebat, J; Gleeson, J;
14 Nov 2019 | Genome Research | 30(1):49-61
Li, S; Kendall, J; Park, S; Wang, Z; Alexander, J; Moffitt, A; Ranade, N; Danyko, C; Gegenhuber, B; Fischer, S; Robinson, B; Lepor, H; Tollkuhn, J; Gillis, J; Brouzes, E; Krasnitz, A; Levy, D; Wigler, M;
12 Aug 2019 | PLoS ONE | 14(8):e0220617
Liang, D; McHugh, K; Brophy, P; Shaikh, N; Manak, J; Andrews, P; Hakker, I; Wang, Z; Schwaderer, A; Hains, D;