Seungtai (Chris) Yoon
Research Assistant Professor
Ph.D., Stony Brook University, 2006
[email protected] | 516-367-5024
Genetics contribute to Autism in large degree. Modern genetics research demands an interdisciplinary approach to interpreting data generated from various high-throuput technologies. We are developing computational and statistical methods to analyze genomic data, with the goal of identifying mechanisms that cause genetic changes underlying autism.
Autism has been known for high heritability. Recently, high-throughput technologies such as microarray and next-generation sequencing enabled identification of de novo mutations associated with autism in simplex cohorts. Thus, the Yoon lab is working on finding de novo CNVs (Copy Number Variations) in higher resolution from sequencing data. Furthermore, causal mechanisms due to those mutations can be found by various approaches such as single-cell sequencing and RNA analysis. Thus, the Yoon lab is also analyzing data from these various platforms to explain genetic etiology of autism.
All Publications
14 Jun 2023 | Cell Genomics | 3(6):100319
Wroten, Mathew; Yoon, Seungtai; Andrews, Peter; Yamrom, Boris; Ronemus, Michael; Buja, Andreas; Krieger, Abba; Levy, Dan; Ye, Kenny; Wigler, Michael; Iossifov, Ivan;
1 Sep 2021 | Communications Biology | 4(1):1026
Yoon, Seungtai; Munoz, Adriana; Yamrom, Boris; Lee, Yoon-Ha; Andrews, Peter; Marks, Steven; Wang, Zihua; Reeves, Catherine; Winterkorn, Lara; Krieger, Abba; Buja, Andreas; Pradhan, Kith; Ronemus, Michael; Baldwin, Kristin; Levy, Dan; Wigler, Michael; Iossifov, Ivan;
30 Sep 2015 | Nature | 526(7571):68-74
Consortium, 1000;
14 Nov 2014 | Nature | 515(7526):216-221
Iossifov, I; O'Roak, B; Sanders, S; Ronemus, M; Krumm, N; Levy, D; Stessman, H; Witherspoon, K; Vives, L; Patterson, K; Smith, J; Paeper, B; Nickerson, D; Dea, J; Dong, S; Gonzalez, L; Mandell, J; Mane, S; Murtha, M; Sullivan, C; Walker, M; Waqar, Z; Wei, L; Willsey, A; Yamrom, B; Lee, Y; Grabowska, E; Dalkic, E; Wang, Z; Marks, S; Andrews, P; Leotta, A; Kendall, J; Hakker, I; Rosenbaum, J; Ma, B; Rodgers, L; Troge, J; Narzisi, G; Yoon, S; Schatz, M; Ye, K; McCombie, W; Shendure, J; Eichler, E; State, M; Wigler, M;
30 Jun 2014 | Genome Biology | 15(6):R88
Colonna, Vincenza; Ayub, Qasim; Chen, Yuan; Pagani, Luca; Luisi, Pierre; Pybus, Marc; Garrison, Erik; Xue, Yali; Tyler-Smith, Chris; 1000 Genomes Project Consortium; Abecasis, Goncalo; Auton, Adam; Brooks, Lisa; DePristo, Mark; Durbin, Richard; Handsaker, Robert; Kang, Hyun; Marth, Gabor; McVean, Gil;
13 Jun 2014 | Nature Communications | 5:3934
Delaneau, O; Marchini, J; McVeanh, G; Donnelly, P; Lunter, G; Marchini, J; Myers, S; Gupta-Hinch, A; Iqbal, Z; Mathieson, I; Rimmer, A; Xifara, D; Kerasidou, A; Churchhouse, C; Altshuler, D; Gabriel, S; Lander, E; Gupta, N; Daly, M; DePristo, M; Banks, E; Bhatia, G; Carneiro, M; Del Angel, G; Genovese, G; Handsaker, R; Hartl, C; McCarroll, S; Nemesh, J; Poplin, R; Schaffner, S; Shakir, K; Sabeti, P; Grossman, S; Tabrizi, S; Tariyal, R; Li, H; Reich, D; Durbin, R; Hurles, M; Balasubramaniam, S; Burton, J; Danecek, P; Keane, T; Kolb-Kokocinski, A; McCarthy, S; Stalker, J; Quail, M; Ayub, Q; Chen, Y; Coffey, A; Colonna, V; Huang, N; Jostins, L; Scally, A; Walter, K; Xue, Y; Zhang, Y; Blackburne, B; Lindsay, S; Ning, Z; Frankish, A; Harrow, J; Chris, T; Abecasis, G; Kang, H; Anderson, P; Blackwell, T; Busonero, F; Fuchsberger, C; Jun, G; Maschio, A; Porcu, E; Sidore, C; Tan, A; Trost, M; Bentley, D; Grocock, R; Humphray, S; James, T; Kingsbury, Z; Bauer, M; Cheetham, R; Cox, T; Eberle, M; Murray, L; Shaw, R; Chakravarti, A; Clark, A; Keinan, A; Rodriguez-Flores, J; De LaVega, F; Degenhardt, J; Eichler, E; Flicek, P; Clarke, L; Leinonen, R; Smith, R; Zheng-Bradley, X; Beal, K;
Jun 2014 | Molecular Psychiatry | 19(6):652-658
McCarthy, S; Gillis, J; Kramer, M; Lihm, J; Yoon, S; Berstein, Y; Mistry, M; Pavlidis, P; Solomon, R; Ghiban, E; Antoniou, E; Kelleher, E; O'Brien, C; Donohoe, G; Gill, M; Morris, D; McCombie, W; Corvin, A;
4 Oct 2013 | Science | 342(6154):1235587
Khurana, Ekta; Fu, Yao; Colonna, Vincenza; Mu, Xinmeng; Kang, Hyun; Lappalainen, Tuuli; Sboner, Andrea; Lochovsky, Lucas; Chen, Jieming; Harmanci, Arif; Das, Jishnu; Abyzov, Alexej; Balasubramanian, Suganthi; Beal, Kathryn; Chakravarty, Dimple; Challis, Daniel; Chen, Yuan; Clarke, Declan; Clarke, Laura; Cunningham, Fiona; Evani, Uday; Flicek, Paul; Fragoza, Robert; Garrison, Erik; Gibbs, Richard; Gümü艧, Zeynep; Herrero, Javier; Kitabayashi, Naoki; Kong, Yong; Lage, Kasper; Liluashvili, Vaja; Lipkin, Steven; MacArthur, Daniel; Marth, Gabor; Muzny, Donna; Pers, Tune; Ritchie, Graham; Rosenfeld, Jeffrey; Sisu, Cristina; Wei, Xiaomu; Wilson, Michael; Xue, Yali; Yu, Fuli; 1000 Genomes Project Consortium; Dermitzakis, Emmanouil; Yu, Haiyuan; Rubin, Mark; Tyler-Smith, Chris; Gerstein, Mark;
Oct 2013 | Genomics | 102(4):270-277
Schafer, Chad; Campbell, Nicholas; Cai, Guiqing; Yu, Fei; Makarov, Vladimir; Yoon, Seungtai; Daly, Mark; Gibbs, Richard; Schellenberg, Gerard; Devlin, Bernie; Sutcliffe, James; Buxbaum, Joseph; Roeder, Kathryn;
2013 | PLoS ONE | 8(8):e70376
Ozomaro, Uzoezi; Cai, Guiqing; Kajiwara, Yuji; Yoon, Seungtai; Makarov, Vladimir; Delorme, Richard; Betancur, Catalina; Ruhrmann, Stephan; Falkai, Peter; Grabe, Hans; Maier, Wolfgang; Wagner, Michael; Lennertz, Leonhard; Moessner, Rainald; Murphy, Dennis; Buxbaum, Joseph; Züchner, Stephan; Grice, Dorothy;