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Semir Beyaz

Semir Beyaz

Assistant Professor
Cancer Center Member

Ph.D., Harvard University, 2017

[email protected] | 516-367-4128

 

Are you really what you eat? Our goal is to uncover the precise mechanisms that link nutrition to organismal health and disease states at the cellular and molecular level. A particular focus in our lab is to understand how dietary perturbations affect the immune system and contribute to the risk of diseases that are associated with immune dysfunction such as cancer.

Our laboratory deciphers how nutritional cues and metabolic鈥揺pigenetic cross-talk sculpt cellular networks that sustain healthy tissue function鈥攁nd how their disruption drives maladaptive remodeling in diseases such as colon and endometrial cancers as well as in endometriosis. We integrate genomic, transcriptomic, and epigenomic profiling with metabolic measurements, biochemical assays, and microbiome analyses to deconstruct the signaling circuits underlying these outcomes. Anchoring our studies in patient-derived tissue specimens and organoid platforms ensures every mechanistic insight is rooted in human biology鈥攁nd directly informs the discovery of biomarkers and therapeutic targets for prevention, early diagnosis, and treatment of these debilitating diseases.

Cells respond and adapt to the signals that they receive from their environment. Environmental factors such as nutrients affect cellular states by altering cell state-specific gene expression or metabolic programs. My research group investigates the causal cellular and molecular mechanisms that link nutrition to organismal health and disease. For example, diets that lead to obesity, such as high fat diets are significant environmental risk factors that influence cancer incidence and progression in several tissues. Although the interactions between tumor cells and the immune system play a significant role in tumorigenesis, little is known about how dietary perturbations impact immunity against cancer. Our studies interrogate the functional consequences of diets on immune recognition and response pathways that play critical role in cancer immunity. By identifying the altered gene expression and metabolic programs in the immune system in response to dietary perturbations, our goal is to uncover mechanistic links that can be therapeutically exploited for the treatment of diseases associated with immune dysfunction such as cancer.

I have joined forces with Dr. Tamer Seckin at Northwell Health to tackle endometriosis.

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CSHL Fellow Semir Beyaz wins three awards
The Janeway Award, New England Immunology Conference
Trainee Award, American Association of Immunologists
Outstanding Poster Award, International Society for Stem Cell Research
Zhongmei Chen Yong Travel Award for Scientific Excellence, International Society for Stem Cell Research
Merit Award, International Society for Stem Cell Research
Thermo-Fisher Trainee Achievement Award, American Association of Immunologists



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Selected Publications

1 Apr 2021 | Cell Stem Cell | 28(4):598-599
Beyaz, Semir;  Mana, Miyeko;  Yilmaz, Ömer;  

15 Oct 2020 | Mucosal Immunology
Gaudino, S;  Beaupre, M;  Lin, X;  Joshi, P;  Rathi, S;  McLaughlin, P;  Kempen, C;  Mehta, N;  Eskiocak, O;  Yueh, B;  Blumberg, R;  van der Velden, A;  Shroyer, K;  Bialkowska, A;  Beyaz, S;  Kumar, P;  

8 Sep 2020 | bioRxiv
Beyaz, S;  Roper, J;  Bauer-Rowe, K;  Xifaras, M;  Ergin, I;  Dohnalova, L;  Biton, M;  Shekar, K;  Mou, H;  Eskiocak, O;  Ozata, D;  Papciak, K;  Chung, C;  Almeqdadi, M;  Fein, M;  Valle-Encinas, E;  Erdemir, A;  Dogum, K;  Garipcan, A;  Meyer, H;  Fox, J;  Elinav, E;  Kucukural, A;  Kumar, P;  McAleer, J;  Thaiss, C;  Regev, A;  Orkin, S;  Yilmaz, O;  

3 Feb 2020 | Nature Reviews Immunology | 20(5):308-320
Ordovas-Montanes, J;  Beyaz, S;  Rakoff-Nahoum, S;  Shalek, A;  

25 Jul 2019 | Gastroenterology | 157(5)
Luo, Y;  Yang, Y;  Liu, M;  Wang, D;  Wang, F;  Bi, Y;  Ji, J;  Li, S;  Liu, Y;  Chen, R;  Huang, H;  Wang, X;  Swidnicka-Siergiejko, A;  Janowitz, T;  Beyaz, S;  Wang, G;  Xu, S;  Bialkowska, A;  Luo, C;  Pin, C;  Liang, G;  Lu, X;  Wu, M;  Shroyer, K;  Wolff, R;  Plunkett, W;  Ji, B;  Li, Z;  Li, E;  Li, X;  Yang, V;  Logsdon, C;  Abbruzzese, J;  Lu, W;  

All Publications

1 Apr 2025 | Cell Stem Cell
Bhattacharya, Swarnabh;  Tie, Guodong;  Singh, Pratik;  Malagola, Ermanno;  Eskiocak, Onur;  He, Ruiyang;  Kraiczy, Judith;  Gu, Wei;  Perlov, Yakov;  Alici-Garipcan, Aybuke;  Beyaz, Semir;  Wang, Timothy;  Zhou, Qiao;  Shivdasani, Ramesh;  

8 Feb 2025 | bioRxiv
Bhattacharya, Swarnabh;  Tei, Guodong;  Singh, Pratik;  Malagola, Ermanno;  Eskiocak, Onur;  He, Ruiyang;  Kraiczy, Judith;  Gu, Wei;  Perlov, Yakov;  Beyaz, Semir;  Wang, Timothy;  Zhou, Qiao;  Shivdasani, Ramesh;  

20 Oct 2024 | Bio-protocol | 14(20):e5093
Barbi, Mali;  Gowthaman, Divya;  Katcher, Arielle;  Gorman, Megan;  Yueh, Brian;  Nizam, Aaron;  Chung, Charlie;  Akyildiz, Erdogan;  Frimer, Marina;  Goldberg, Gary;  Beyaz, Semir;  

7 Aug 2024 | Nature
Soula, Mariluz;  Unlu, Gokhan;  Welch, Rachel;  Chudnovskiy, Aleksey;  Uygur, Beste;  Shah, Vyom;  Alwaseem, Hanan;  Bunk, Paul;  Subramanyam, Vishvak;  Yeh, Hsi-Wen;  Khan, Artem;  Heissel, Søren;  Goodarzi, Hani;  Victora, Gabriel;  Beyaz, Semir;  Birsoy, K谋vanç;  

11 Jun 2024 | Nature Microbiology
Tierney, Braden;  Kim, JangKeun;  Overbey, Eliah;  Ryon, Krista;  Foox, Jonathan;  Sierra, Maria;  Bhattacharya, Chandrima;  Damle, Namita;  Najjar, Deena;  Park, Jiwoon;  Garcia Medina, J;  Houerbi, Nadia;  Meydan, Cem;  Wain Hirschberg, Jeremy;  Qiu, Jake;  Kleinman, Ashley;  Al-Ghalith, Gabriel;  MacKay, Matthew;  Afshin, Evan;  Dhir, Raja;  Borg, Joseph;  Gatt, Christine;  Brereton, Nicholas;  Readhead, Benjamin;  Beyaz, Semir;  Venkateswaran, Kasthuri;  Wiseman, Kelly;  Moreno, Juan;  Boddicker, Andrew;  Zhao, Junhua;  Lajoie, Bryan;  Scott, Ryan;  Altomare, Andrew;  Kruglyak, Semyon;  Levy, Shawn;  Church, George;  Mason, Christopher;