Paolo Cifani
Research Associate Professor/Director, Mass Spectrometry Shared Resource
Cancer Center Member
Ph.D., Lund University, 2013
[email protected] | 516-367-6806
We develop innovative mass spectrometry-based approaches to measure how protein activities are regulated under physiologic conditions and in pathological states.
The vast majority of cellular biochemical processes are mediated by the coordinated activities of proteins. Protein activities are in turn controlled by their concentration and localization, by chemical modification of specific amino acids, by interaction with other biomolecules, and by several other mechanisms. Different cellular functional states, including those observed in cancer and other diseases, are almost invariably defined by specific patterns of protein regulation. The Cifani lab develops innovative approaches to study protein regulation using high-resolution mass spectrometry and liquid chromatography. Using these methods, we aim to reveal differences in concentration, structure, and chemical modification of cellular proteins from minimal sample amounts, such as those obtained from clinical specimens.
All Publications
12 Aug 2025 | ACS Nano
Bellat, Vanessa; Glaser, Adam; Gong, Henry; Gill, Aman; Lee, Young; Cifani, Paolo; Stokol, Tracy; Vahdat, Linda; Law, Benedict;
1 Jul 2025 | Proceedings of the National Academy of Sciences of the United States of America | 122(27):e2426218122
Moresco, Philip; Kastan, Jonathan; Yang, Jung-In; Prabakar, Rishvanth; Kelley, Z; Minicozzi, Francesca; Adams, Dexter; Cifani, Paolo; Tuveson, David; Fearon, Douglas;
20 Apr 2025 | bioRxiv
Gaur, Mohita; Liang, Xulong; Brooks, Matthew; Jiang, Ke; Kumari, Anjani; English, Milton; Cifani, Paolo; Panepinto, Maria; Nellissery, Jacob; Fariss, Robert; Campello, Laura; Marchal, Claire; Swaroop, Anand;
15 Apr 2025 | bioRxiv
Chen, Yanyang; Toufektchan, Eleonore; Luan, Xiaohan; Hickling, James; Norman, Roshan; Cifani, Paolo; Kentsis, Alex; Zhou, Wen; Maciejowski, John;
22 Jan 2025 | Nature Communications | 16(1):941
Garg, Ankur; On, Kin; Xiao, Yang; Elkayam, Elad; Cifani, Paolo; David, Yael; Joshua-Tor, Leemor;
20 Jan 2025 | bioRxiv
Moresco, Philip; Kastan, Jonathan; Yang, Jung-In; Prabakar, Rishvanth; Minicozzi, Francesca; Adams, Dexter; Cifani, Paolo; Tuveson, David; Fearon, Douglas;
25 Oct 2024 | Science | 386(6720):eadk9167
Swamynathan, Manojit; Kuang, Shan; Watrud, Kaitlin; Doherty, Mary; Gineste, Charlotte; Mathew, Grinu; Gong, Grace; Cox, Hilary; Cheng, Eileen; Reiss, David; Kendall, Jude; Ghosh, Diya; Reczek, Colleen; Zhao, Xiang; Herzka, Tali; Špokait臈, Saul臈; Dessus, Antoine; Kim, Seung; Klingbeil, Olaf; Liu, Juan; Nowak, Dawid; Alsudani, Habeeb; Wee, Tse-Luen; Park, Youngkyu; Minicozzi, Francesca; Rivera, Keith; Almeida, Ana; Chang, Kenneth; Chakrabarty, Ram; Wilkinson, John; Gimotty, Phyllis; Diermeier, Sarah; Egeblad, Mikala; Vakoc, Christopher; Locasale, Jason; Chandel, Navdeep; Janowitz, Tobias; Hicks, James; Wigler, Michael; Pappin, Darryl; Williams, Roger; Cifani, Paolo; Tuveson, David; Laporte, Jocelyn; Trotman, Lloyd;
31 Aug 2024 | Cell Reports | 43(9):114676
Yang, Xiaochun; Bhowmick, Krishanu; Rao, Shuyun; Xiang, Xiyan; Ohshiro, Kazufumi; Amdur, Richard; Hassan, Md; Mohammad, Taj; Crandall, Keith; Cifani, Paolo; Shetty, Kirti; Lyons, Scott; Merrill, Joseph; Vegesna, Anil; John, Sahara; Latham, Patricia; Crawford, James; Mishra, Bibhuti; Dasarathy, Srinivasan; Wang, Xin; Yu, Herbert; Wang, Zhanwei; Huang, Hai; Krainer, Adrian; Mishra, Lopa;
5 Aug 2024 | bioRxiv
Garg, Ankur; On, Kin; Xiao, Yang; Elkayam, Elad; Cifani, Paolo; David, Yael; Joshua-Tor, Leemor;
26 Jul 2024 | Cancer Discovery
Klingbeil, Olaf; Skopelitis, Damianos; Tonelli, Claudia; Yoshimoto, Toyoki; Alpsoy, Aktan; Panepinto, Maria; Minicozzi, Francesca; Merrill, Joseph; Cafiero, Amanda; Aggarwal, Disha; Russo, Suzanne; Ha, Taehoon; Demerdash, Osama; Wee, Tse-Luen; Spector, David; Lyons, Scott; Tuveson, David; Cifani, Paolo; Vakoc, Christopher;