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Michael Wigler

Michael Wigler

Professor
Russell and Janet Doubleday Professor of Cancer Research
Cancer Center Member

Ph.D., Columbia University, 1978

[email protected] | 516-367-8377

 

Devastating diseases like cancer and autism can be caused by spontaneous changes to our DNA—mutations first appearing in the child, or in our tissues as we age. We are developing methods to discover these changes in individuals, tumors, and even single cells, to promote early detection and treatments

Michael Wigler鈥檚 work provides a new paradigm for understanding and exploring human disease. The Wigler lab studies human cancer and the contribution of new mutation to genetic disorders. The cancer effort (with James Hicks, Alex Krasnitz, and Lloyd Trotman) focuses on breast and prostate cancers. It involves collaborative clinical studies to discover mutational patterns predicting treatment response and outcome and the development of diagnostics to detect cancer cells in bodily fluids such as blood and urine. The major tools are single-cell DNA and RNA analysis. The single-cell methods, which are in development, are also being applied to problems in neurobiology (with Josh Huang and Pavel Osten) to characterize neuronal subtypes, somatic mutation, and monoallelic expression. The Wigler lab鈥檚 genetic efforts are a collaboration with Ivan Iossifov and Dan Levy, and this team focuses on determining the role of new mutations in pediatric disorders. In a large-scale population sequencing project with W. Richard McCombie and the Genome Sequencing Center at Washington University in St. Louis, and supported by the Simons Foundation, the team has proven the contribution of this mechanism to autism. The work further suggests a relationship between the mutational targets in autism and the process of neuroplasticity that lies at the heart of learning. Smaller-scale population studies of congenital heart disease and pediatric cancer (collaborations with scientists at Columbia University and Memorial Sloan- Kettering Cancer Center, respectively) also point to new mutation as a causal factor in these disorders.

Wigler elected AACR Academy Fellow

See all Wigler news

Selected Publications

20 May 2020 | JCO clinical cancer informatics | 4:464-471
Chorbadjiev, L;  Kendall, J;  Alexander, J;  Zhygulin, V;  Song, J;  Wigler, M;  Krasnitz, A;  

13 May 2020 | eLife | 9:e51480
Baslan, T;  Kendall, J;  Volyanskyy, K;  McNamara, K;  Cox, H;  D'Italia, S;  Ambrosio, F;  Riggs, M;  Rodgers, L;  Leotta, A;  Song, J;  Mao, Y;  Wu, J;  Shah, R;  Gularte-Merida, R;  Chadalavada, K;  Nanjangud, G;  Varadan, V;  Gordon, A;  Curtis, C;  Krasnitz, A;  Dimitrova, N;  Harris, L;  Wigler, M;  Hicks, J;  

24 Feb 2020 | Developmental Cell | 52(4):413-428
Vasudevan, A;  Baruah, P;  Smith, J;  Wang, Z;  Sayles, N;  Andrews, P;  Kendall, J;  Leu, J;  Chunduri, N;  Levy, D;  Wigler, M;  Storchova, Z;  Sheltzer, J;  

21 Feb 2020 | Nucleic Acids Research (NAR) | 48(7):e40
Moffitt, A;  Spector, M;  Andrews, P;  Kendall, J;  Alexander, J;  Stepansky, A;  Ma, B;  Kolitz, J;  Chiorazzi, N;  Allen, S;  Krasnitz, A;  Wigler, M;  Levy, D;  Wang, Z;  

14 Nov 2019 | Genome Research | 30(1):49-61
Li, S;  Kendall, J;  Park, S;  Wang, Z;  Alexander, J;  Moffitt, A;  Ranade, N;  Danyko, C;  Gegenhuber, B;  Fischer, S;  Robinson, B;  Lepor, H;  Tollkuhn, J;  Gillis, J;  Brouzes, E;  Krasnitz, A;  Levy, D;  Wigler, M;  

All Publications

27 Sep 2025 | Genome Biology | 26(1):314
Li, Siran;  Alexander, Joan;  Kendall, Jude;  Andrews, Peter;  Rose, Elizabeth;  Orjuela, Hope;  Park, Sarah;  Podszus, Craig;  Shanley, Liam;  Ranade, Nissim;  Morris, Patrick;  Stauder, Danielle;  Bradford, Daniel;  Laster, Zachary;  Ronemus, Michael;  Rishi, Arvind;  Frimer, Marina;  Ma, Rong;  Donoho, David;  Goldberg, Gary;  Wigler, Michael;  Levy, Dan;  

25 Oct 2024 | Science | 386(6720):eadk9167
Swamynathan, Manojit;  Kuang, Shan;  Watrud, Kaitlin;  Doherty, Mary;  Gineste, Charlotte;  Mathew, Grinu;  Gong, Grace;  Cox, Hilary;  Cheng, Eileen;  Reiss, David;  Kendall, Jude;  Ghosh, Diya;  Reczek, Colleen;  Zhao, Xiang;  Herzka, Tali;  Špokait臈, Saul臈;  Dessus, Antoine;  Kim, Seung;  Klingbeil, Olaf;  Liu, Juan;  Nowak, Dawid;  Alsudani, Habeeb;  Wee, Tse-Luen;  Park, Youngkyu;  Minicozzi, Francesca;  Rivera, Keith;  Almeida, Ana;  Chang, Kenneth;  Chakrabarty, Ram;  Wilkinson, John;  Gimotty, Phyllis;  Diermeier, Sarah;  Egeblad, Mikala;  Vakoc, Christopher;  Locasale, Jason;  Chandel, Navdeep;  Janowitz, Tobias;  Hicks, James;  Wigler, Michael;  Pappin, Darryl;  Williams, Roger;  Cifani, Paolo;  Tuveson, David;  Laporte, Jocelyn;  Trotman, Lloyd;  

14 Jun 2023 | Cell Genomics | 3(6):100319
Wroten, Mathew;  Yoon, Seungtai;  Andrews, Peter;  Yamrom, Boris;  Ronemus, Michael;  Buja, Andreas;  Krieger, Abba;  Levy, Dan;  Ye, Kenny;  Wigler, Michael;  Iossifov, Ivan;  

1 Jan 2023 | Advanced Materials Technologies
Lammertse, E;  Li, S;  Kendall, J;  Kim, C;  Morris, P;  Ranade, N;  Levy, D;  Wigler, M;  Brouzes, E;  

12 Sep 2022 | Nucleic Acids Research (NAR) | :gkac723
Wang, Zihua;  Moffitt, Andrea;  Andrews, Peter;  Wigler, Michael;  Levy, Dan;