Michael Ronemus
Research Assistant Professor
Ph.D., Yale University 1998
My research is aimed at uncovering the basis of sporadic genetic diseases such as autism, congenital heart defects and early-onset cancers.
Ronemus develops wet bench and bioinformatics techniques to detect different classes of rare mutations that underlie sporadic genetic disease in humans. The work utilizes novel next-gen sequencing approaches to rapidly and inexpensively evaluate large numbers of affected individuals. Working with the Wigler lab, Ronemus has mainly focused on the autism spectrum, but these these techniques are also being applied to other common pediatric disorders with similar genetic etiology such as congenital heart disease. In collaboration with clinical partners, the researchers are now in the process of translating these technologies into medically actionable tests.
All Publications
27 Sep 2025 | Genome Biology | 26(1):314
Li, Siran; Alexander, Joan; Kendall, Jude; Andrews, Peter; Rose, Elizabeth; Orjuela, Hope; Park, Sarah; Podszus, Craig; Shanley, Liam; Ranade, Nissim; Morris, Patrick; Stauder, Danielle; Bradford, Daniel; Laster, Zachary; Ronemus, Michael; Rishi, Arvind; Frimer, Marina; Ma, Rong; Donoho, David; Goldberg, Gary; Wigler, Michael; Levy, Dan;
5 Feb 2025 | Biochemical Society Transactions | 53(1)
Ronemus, Michael; Bradford, Daniel; Laster, Zachary; Li, Siran;
14 Jun 2023 | Cell Genomics | 3(6):100319
Wroten, Mathew; Yoon, Seungtai; Andrews, Peter; Yamrom, Boris; Ronemus, Michael; Buja, Andreas; Krieger, Abba; Levy, Dan; Ye, Kenny; Wigler, Michael; Iossifov, Ivan;
1 Sep 2021 | Communications Biology | 4(1):1026
Yoon, Seungtai; Munoz, Adriana; Yamrom, Boris; Lee, Yoon-Ha; Andrews, Peter; Marks, Steven; Wang, Zihua; Reeves, Catherine; Winterkorn, Lara; Krieger, Abba; Buja, Andreas; Pradhan, Kith; Ronemus, Michael; Baldwin, Kristin; Levy, Dan; Wigler, Michael; Iossifov, Ivan;
Dec 2020 | Journal of Molecular Diagnostics | 22(12):1476-1481
Jobanputra, Vaidehi; Andrews, Peter; Felice, Vanessa; Abhyankar, Avinash; Kozon, Lukasz; Robinson, Dino; London, Ferrah; Hakker, Inessa; Wrzeszczynski, Kazimierz; Ronemus, Michael;
25 Jan 2018 | Nucleic Acids Research (NAR) | 46(2):e10
Kumar, V; Rosenbaum, J; Wang, Z; Forcier, T; Ronemus, M; Wigler, M; Levy, D;
13 Jun 2017 | bioRxiv
Kumar, Vijay; Rosenbaum, Julie; Wang, Zihua; Forcier, Talitha; Ronemus, Michael; Wigler, Michael; Levy, Dan;
Dec 2016 | Nature Protocols | 11(12):2529-2548
Fang, H; Bergmann, E; Arora, K; Vacic, V; Zody, M; Iossifov, I; O'Rawe, J; Wu, Y; Jimenez Barron, L; Rosenbaum, J; Ronemus, M; Lee, Y; Wang, Z; Dikoglu, E; Jobanputra, V; Lyon, G; Wigler, M; Schatz, M; Narzisi, G;
Jun 2016 | Genome Research | 26(6):844-51
Wang, Z; Andrews, P; Kendall, J; Ma, B; Hakker, I; Rodgers, L; Ronemus, M; Wigler, M; Levy, D;
Indel variant analysis of short-read sequencing data with Scalpel (vol 11, pg 2529, 2016)
2016 | Nature Protocols | 11(12)
Fang, Han; Bergmann, Ewa; Arora, Kanika; Vacic, Vladimir; Zody, Michael; Iossifov, Ivan; O'Rawe, Jason; Wu, Yiyang; Barron, Laura; Rosenbaum, Julie; Ronemus, Michael; Lee, Yoon-ha; Wang, Zihua; Dikoglu, Esra; Jobanputra, Vaidehi; Lyon, Gholson; Wigler, Michael; Schatz, Michael; Narzisi, Giuseppe;