Kenneth Chang
Research Associate Professor/Director, Functional Genomics
Cancer Center Member
Ph.D., Stony Brook University, 2002
[email protected] | 516-367-5418
RNA interference (RNAi) and CRISPR are widely used to functionally investigate mammalian genomes. It is our goal to develop and optimize these gene perturbation platforms to improve their effectiveness in understanding the biology of diseases.
Loss-of-function genetics has proven essential for interrogating the functions of genes and for probing their roles within the complex circuitry of biological pathways. Kenneth Chang developed genetic approaches for perturbing genes using shRNAs (RNAi), optimized the effectiveness of these shRNA designs, and created shRNA infrastructure and resources for genetic screens in mammalian cells. These resources include shRNA libraries modeled after microRNAs (miRNAs) and algorithms for predicting highly potent shRNA designs. Dr. Chang has performed many genetic screens in cancer cells and has expanded his research to include a significant focus on CRISPR technologies and their applications. The lab鈥檚 goal is to leverage these technologies to promote a deeper understanding of cancer pathways and dependencies, with the potential for discovery of new therapeutic targets and generation of disease-relevant models for improving human health. As the Director of the Functional Genomics Shared Resource, Dr. Chang and his lab also provide access to advanced RNAi/CRISPR technologies, construction of custom RNAi/CRISPR libraries, and assists in the design and implementation of genetic screens to support research programs at CSHL and the scientific community.
- New research explains why even targeted therapies eventually fail in lung cancer
- CSHL team finds a way to make shRNA gene knockdown more effective
- New method powerfully boosts efficiency of RNA interference (RNAi) in shutting down genes
- CSHL scientists harness logic of 鈥淪udoku鈥� math puzzle to vastly enhance genome-sequencing capability
- Scientists at 黑料吃瓜资源 hone method to selectively target cancer genes and cells
- RNA Interference Library covers entire human genome
All Publications
28 Nov 2024 | Nature Communications | 15(1):10364
Song, Dongyan; Cen, Yuxin; Qian, Zhe; Wu, Xiaoli; Rivera, Keith; Wee, Tse-Luen; Demerdash, Osama; Chang, Kenneth; Pappin, Darryl; Vakoc, Christopher; Tonks, Nicholas;
25 Oct 2024 | Science | 386(6720):eadk9167
Swamynathan, Manojit; Kuang, Shan; Watrud, Kaitlin; Doherty, Mary; Gineste, Charlotte; Mathew, Grinu; Gong, Grace; Cox, Hilary; Cheng, Eileen; Reiss, David; Kendall, Jude; Ghosh, Diya; Reczek, Colleen; Zhao, Xiang; Herzka, Tali; Špokait臈, Saul臈; Dessus, Antoine; Kim, Seung; Klingbeil, Olaf; Liu, Juan; Nowak, Dawid; Alsudani, Habeeb; Wee, Tse-Luen; Park, Youngkyu; Minicozzi, Francesca; Rivera, Keith; Almeida, Ana; Chang, Kenneth; Chakrabarty, Ram; Wilkinson, John; Gimotty, Phyllis; Diermeier, Sarah; Egeblad, Mikala; Vakoc, Christopher; Locasale, Jason; Chandel, Navdeep; Janowitz, Tobias; Hicks, James; Wigler, Michael; Pappin, Darryl; Williams, Roger; Cifani, Paolo; Tuveson, David; Laporte, Jocelyn; Trotman, Lloyd;
20 May 2024 | Cancer Discovery
Zhang, Xu; Duan, Shoufu; Apostolou, Panagiota; Wu, Xiaoping; Watanabe, Jun; Gallitto, Matthew; Barron, Tara; Taylor, Kathryn; Woo, Pamelyn; Hua, Xu; Zhou, Hui; Wei, Hong-Jian; McQuillan, Nicholas; Kang, Kyung-Don; Friedman, Gregory; Canoll, Peter; Chang, Kenneth; Wu, Cheng-Chia; Hashizume, Rintaro; Vakoc, Christopher; Monje, Michelle; McKhann, Guy; Gogos, Joseph; Zhang, Zhiguo;
5 Sep 2023 | Proceedings of the National Academy of Sciences of the United States of America | 120(36):e2303859120
Sroka, Martyna; Skopelitis, Damianos; Vermunt, Marit; Preall, Jonathan; El Demerdash, Osama; de Almeida, Larissa; Chang, Kenneth; Utama, Raditya; Gryder, Berkley; Caligiuri, Giuseppina; Ren, Diqiu; Nalbant, Benan; Milazzo, Joseph; Tuveson, David; Dobin, Alexander; Hiebert, Scott; Stengel, Kristy; Mantovani, Roberto; Khan, Javed; Kohli, Rahul; Shi, Junwei; Blobel, Gerd; Vakoc, Christopher;
21 Dec 2022 | Nature
Sun, Xueqin; Klingbeil, Olaf; Lu, Bin; Wu, Caizhi; Ballon, Carlos; Ouyang, Meng; Wu, Xiaoli; Jin, Ying; Hwangbo, Yon; Huang, Yu-Han; Somerville, Tim; Chang, Kenneth; Park, Jung; Chung, Taemoon; Lyons, Scott; Shi, Junwei; Vogel, Hannes; Schulder, Michael; Vakoc, Christopher; Mills, Alea;
28 Oct 2022 | Cancer Discovery | :CD-21
Mo, Yan; Duan, Shoufu; Zhang, Xu; Hua, Xu; Zhou, Hui; Wei, Hong-Jian; Watanabe, Jun; McQuillan, Nicholas; Su, Zhenyi; Gu, Wei; Wu, Cheng-Chia; Vakoc, Christopher; Hashizume, Rintaro; Chang, Kenneth; Zhang, Zhiguo;
22 Feb 2022 | Nature Communications | 13(1):1001
Gutbrod, M; Roche, B; Steinberg, J; Lakhani, A; Chang, K; Schorn, A; Martienssen, R;
29 Jan 2022 | Oncogene
Bharathy, Narendra; Cleary, Megan; Kim, Jin-Ah; Nagamori, Kiyo; Crawford, Kenneth; Wang, Eric; Saha, Debarya; Settelmeyer, Teagan; Purohit, Reshma; Skopelitis, Damianos; Chang, Kenneth; Doran, Jessica; Kirschbaum, C; Bharathy, Suriya; Crews, Davis; Randolph, Matthew; Karnezis, Anthony; Hudson-Price, Lisa; Dhawan, Jyotsna; Michalek, Joel; Ciulli, Alessio; Vakoc, Christopher; Keller, Charles;
16 Sep 2021 | Cancer Discovery | :candisc.1849.2020
Wei, Yiliang; Huang, Yu-Han; Skopelitis, Damianos; Iyer, Shruti; Costa, Ana; Yang, Zhaolin; Kramer, Melissa; Adelman, Emmalee; Klingbeil, Olaf; Demerdash, Osama; Polyanskaya, Sofya; Chang, Kenneth; Goodwin, Sara; Hodges, Emily; McCombie, W; Figueroa, Maria; Vakoc, Christopher;
23 Apr 2021 | Cancer Discovery
Yang, Zhaolin; Wu, Xiaoli; Wei, Yiliang; Polyanskaya, Sofya; Iyer, Shruti; Jung, Moonjung; Lach, Francis; Adelman, Emmalee; Klingbeil, Olaf; Milazzo, Joseph; Kramer, Melissa; Demerdash, Osama; Chang, Kenneth; Goodwin, Sara; Hodges, Emily; McCombie, W; Figueroa, Maria; Smogorzewska, Agata; Vakoc, Christopher;