Johannes Yeh
Research Associate Professor & Director, CSHL Antibody and Phage Display Shared Resource
Cancer Center Member
Ph.D., Cambridge University, 2006
[email protected] | 516-367-8812
Cells orchestrate proteins to conduct cell-cell communications and environment sensing in order to execute physiological functions. My lab investigates the mechanisms by which dysregulated signals cause diseases such as cancer, and we are developing therapeutics based on these mechanisms.
Cell signaling plays a central role in executing physiological functions such as cell growth, proliferation and differentiation. Dysregulated cell signaling cause diseases like cancers, diabetes or neurodegeneration. The Yeh lab studies the function of proteins involved in cell signaling and their roles in pathophysiology with the goal of developing therapeutics to abrogate pathological cellular behavior. To this end, we employ biomolecular engineering approaches to dissect signal transduction pathways and to target protein functions. These approaches have led to the development of several therapeutic inhibitors to target oncogenic receptors, transcription factors and extracellular matrix proteins. Most recently, the Yeh lab has been focused on developing therapeutic biologics to modulate the interplay between cancer cells and tumor microenvironment.
All Publications
2 Sep 2025 | ACS Chemical Biology
Fechtmeyer, Phoebe; Martinez, Cameron; Yeh, Johannes;
7 Dec 2024 | bioRxiv
Fechtmeyer, Phoebe; Yeh, Johannes;
26 Sep 2023 | JCI insight | :e172449
Yao, Min; Preall, Jonathan; Yeh, Johannes; Pappin, Darryl; Cifani, Paolo; Zhao, Yixin; Shen, Sophia; Moresco, Philip; He, Brian; Patel, Hardik; Habowski, Amber; King, Daniel; Raphael, Kara; Rishi, Arvind; Sejpal, Divyesh; Weiss, Matthew; Tuveson, David; Fearon, Douglas;
5 Sep 2023 | Genes & Development
Qian, Zhe; Song, Dongyan; Ipsaro, Jonathan; Bautista, Carmelita; Joshua-Tor, Leemor; Yeh, Johannes; Tonks, Nicholas;
01 Sep 2022 | Genes & Development
Farrell, Brian; Gerth, Fabian; Yang, Cheng-Hao; Yeh, Johannes;
The Design and Synthesis of A New Class of Targeted Protein Degradation Inducers
31 Aug 2022 | Genes & Development
Yeh, Johannes; Farrell, Brian; Gerth, Fabian; Yang, Cheng-Hao;
21 Jun 2022 | bioRxiv
Chamberland, Megan; Farrell, Brian; Yeh, Johannes;
10 Sep 2020 | bioRxiv
Oni, Tobiloba; Bautista, Carmelita; Merrill, Joseph; Goos, Jeroen; Rivera, Keith; Miyabayashi, Koji; Biffi, Giulia; Garcia, Libia; Plenker, Dennis; Patel, Hardik; Elyada, Ela; Samaritano, Maria; Yu, Kenneth; Pappin, Darryl; Goggins, Michael; Hruban, Ralph; Lewis, Jason; Lyons, Scott; Yeh, Johannes; Tuveson, David;
28 Sep 2018 | Science | 361(6409)
Albrengues, J; Shields, M; Ng, D; Park, C; Ambrico, A; Poindexter, M; Upadhyay, P; Uyeminami, D; Pommier, A; Kuttner, V; Bruzas, E; Maiorino, L; Bautista, C; Carmona, E; Gimotty, P; Fearon, D; Chang, K; Lyons, S; Pinkerton, K; Trotman, L; Goldberg, M; Yeh, J; Egeblad, M;
20 Aug 2018 | Organic Letters
Howard, T; Cohen, R; Nwajiobi, O; Muneeswaran, Z; Sim, Y; Lahankar, N; Yeh, J; Raj, M;