Every gene has a job to do, but genes rarely act alone. Biologists have built models of molecular interaction networks that represent the complex relationships between thousands of different genes. I am using computational approaches to help define these relationships, work that is helping us to understand the causes of common diseases including autism, bipolar disorder, and cancer.
Ivan Iossifov focuses on the development of new methods and tools for genomic sequence analysis and for building and using molecular networks, and he applies them to specific biomedical problems. He studies the genetics of common diseases in humans using two main tools: next-generation sequencing and molecular networks representing functional relationships among genetic loci. These approaches in combination enable the kind of large-scale studies necessary for furthering our understanding of the complex etiology of disorders such as autism, bipolar disorder, and cancer.
Empowering Insights: The science behind health
November 18, 2024
鈥淭he opportunity to turn curiosity into discoveries that impact the human condition is at the core of CSHL鈥檚 mission,鈥 writes President Stillman.
At the Lab Season 1 Research Rewind: Genetics
October 22, 2024
It鈥檚 the code for all life on Earth. This week At the Lab, we鈥檙e hacking it with the help of 黑料吃瓜资源鈥檚 geneticists.
Autism genetics: The faces behind the data
May 16, 2024
CSHL research on autism involves massive databases with thousands of genomes. Meet a few of the brave individuals who help make this work possible.
President鈥檚 essay: Bringing bold visions to life
May 26, 2023
CSHL President & CEO Bruce Stillman sees the Laboratory as a global hub for scientific expertise and a powerful launchpad for early-career scientists.
The evolution of autism research
May 25, 2023
The conversation around autism has evolved over the past two decades. So has CSHL research. This retrospective shows how we鈥檝e helped move the needle.
Autism in the family tree
May 23, 2023
CSHL scientists have studied the genetics of autism across hundreds of family trees. This animated video shows what they鈥檝e found.
Siblings with autism share more of dad鈥檚 genome, not mom鈥檚
May 22, 2023
CSHL study of more than 6,000 volunteer families overturns a long-held assumption about the genetic origins of autism spectrum disorder.
How well do you know autism spectrum disorders?
April 24, 2023
April is National Autism Awareness Month. Test your knowledge of autism spectrum disorders with this short quiz.
Portrait of a Neuroscience Powerhouse
April 27, 2018
A relatively small neuroscience group at CSHL is having an outsized impact on a dynamic and highly competitive field
Autism genetics study calls attention to impaired motor skills, general cognitive impairment
February 7, 2018
New research on the genetic causes of autism calls attention to diminished motor skills and suggests the importance of broad cognitive impairment
All Publications
16 Sep 2025 | Genome Research
Chorbadjiev, Liubomir; Cokol, Murat; Weinstein, Zohar; Shi, Kevin; Fleisch, Christopher; Dimitrov, Nikolay; Mladenov, Svetlin; Todorov, Ivo; Ivanov, Iordan; Xu, Simon; Ford, Steven; Lee, Yoon-Ha; Yamrom, Boris; Marks, Steven; Munoz, Adriana; Lash, Alex; Volfovsky, Natalia; Iossifov, Ivan;
11 Feb 2024 | bioRxiv
Chorbadjiev, Liubomir; Cokol, Murat; Weinstein, Zohar; Shi, Kevin; Fleisch, Chris; Dimitrov, Nikolay; Mladenov, Svetlin; Xu, Simon; Hall, Jake; Ford, Steven; Lee, Yoon-Ha; Yamrom, Boris; Marks, Steven; Munoz, Adriana; Lash, Alex; Volfovsky, Natalia; Iossifov, Ivan;
5 Oct 2023 | American Journal of Human Genetics | 110(10):1750-1768
Shi, Xi; Lu, Congyi; Corman, Alba; Nikish, Alexandra; Zhou, Yang; Platt, Randy; Iossifov, Ivan; Zhang, Feng; Pan, Jen; Sanjana, Neville;
9 Aug 2023 | Genetics | 224(4):iyad115
Einson, Jonah; Glinos, Dafni; Boerwinkle, Eric; Castaldi, Peter; Darbar, Dawood; de Andrade, Mariza; Ellinor, Patrick; Fornage, Myriam; Gabriel, Stacey; Germer, Soren; Gibbs, Richard; Hersh, Craig; Johnsen, Jill; Kaplan, Robert; Konkle, Barbara; Kooperberg, Charles; Nassir, Rami; Loos, Ruth; Meyers, Deborah; Mitchell, Braxton; Psaty, Bruce; Vasan, Ramachandran; Rich, Stephen; Rienstra, Michael; Rotter, Jerome; Saferali, Aabida; Shoemaker, Moore; Silverman, Edwin; Smith, Albert; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Mohammadi, Pejman; Castel, Stephane; Iossifov, Ivan; Lappalainen, Tuuli; Zhao, H;
14 Jun 2023 | Cell Genomics | 3(6):100319
Wroten, Mathew; Yoon, Seungtai; Andrews, Peter; Yamrom, Boris; Ronemus, Michael; Buja, Andreas; Krieger, Abba; Levy, Dan; Ye, Kenny; Wigler, Michael; Iossifov, Ivan;
31 Jan 2023 | bioRxiv
Einson, Jonah; Glinos, Dafni; Boerwinkle, Eric; Castaldi, Peter; Darbar, Dawood; de Andrade, Mariza; Ellinor, Patrick; Fornage, Myriam; Gabriel, Stacey; Germer, Soren; Gibbs, Richard; Hersh, Craig; Johnsen, Jill; Kaplan, Robert; Konkle, Barbara; Kooperberg, Charles; Nassir, Rami; Loos, Ruth; Meyers, Deborah; Mitchell, Braxton; Psaty, Bruce; Vasan, Ramachandran; Rich, Stephen; Rienstra, Michael; Rotter, Jerome; Saferali, Aabida; Shoemaker, M; Silverman, Edwin; Smith, Albert; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Mohammadi, Pejman; Castel, Stephane; Iossifov, Ivan; Lappalainen, Tuuli;
12 Dec 2022 | bioRxiv
Yamrom, Boris; Lee, Yoon-ha; Marks, Steven; Chorbadjiev, Lubomir; Meyer, Hannah; Iossifov, Ivan;
1 Sep 2021 | Communications Biology | 4(1):1026
Yoon, Seungtai; Munoz, Adriana; Yamrom, Boris; Lee, Yoon-Ha; Andrews, Peter; Marks, Steven; Wang, Zihua; Reeves, Catherine; Winterkorn, Lara; Krieger, Abba; Buja, Andreas; Pradhan, Kith; Ronemus, Michael; Baldwin, Kristin; Levy, Dan; Wigler, Michael; Iossifov, Ivan;
Jul 2020 | Nature | 583(7814):83-89
Abel, Haley; Larson, David; Regier, Allison; Chiang, Colby; Das, Indraniel; Kanchi, Krishna; Layer, Ryan; Neale, Benjamin; Salerno, William; Reeves, Catherine; Buyske, Steven; NHGRI Centers for Common Disease Genomics; Matise, Tara; Muzny, Donna; Zody, Michael; Lander, Eric; Dutcher, Susan; Stitziel, Nathan; Hall, Ira;
5 Mar 2020 | Neurobiology of Learning and Memory | 171(107203)
Venkatasubramani, J; Subramanyam, P; Pal, R; Reddy, B; Srinivasan, D; Chattarji, S; Iossifov, I; Klann, E; Bhattacharya, S;