Novatt proclaims, 鈥淚 firmly believe science doesn’t have to be hard and it doesn’t have to be scary.鈥� Her story shows how that determination can pay off. She landed her dream job because of a tour she led, which became a kind of impromptu interview with the dean of Long Island University鈥檚 College of Pharmacy. He was blown away by her ability to make science accessible.
This would have been even more improbable if the tour was completely scripted and impersonal. But that isn’t how it works at CSHL. Scientists themselves volunteer their free time to lead tours because they want to show the public their world. And with the number of science journalists shrinking鈥�, only 2% of news coverage between 2007 and 2012 focused on science and technology鈥攖he need for scientists to connect with the public directly is growing. This year鈥檚 campus tours will start up again on March 18, and you can sign up here.
The tour that changed Novatt鈥檚 life happened on Father鈥檚 Day Sunday in 2016. She invited her parents along because of the holiday, but it fit with her approach to leading tours. 鈥淚 made a point on my tours to tell people that I was a mom, that I play cello, that I do theater, that I work at my synagogue, and I’m a human as well as a scientist,鈥� Novatt says.
Being human also means failing sometimes. 鈥淚 found it important to tell people about the failed experiments too,鈥� says Novatt, 鈥渂ecause that’s not something that you hear a lot about,鈥� yet it鈥檚 a huge part of life for even the most successful scientists. Novatt explains that it鈥檚 taking scientists so long to cure cancer, for example, because 鈥渋t’s really complicated and a lot of experiments fail.鈥� But she鈥檚 mindful of how the media presents science, and sees how misconceptions can arise 鈥渋f we only communicate that A leads to B leads to C leads to this beautiful conclusion.鈥�
Her experiences in her own lab gave her plenty of stories of failed experiments, but it also gave her a truly . She was part of Professor Adrian Krainer鈥檚 lab, where some of her colleagues had done research that led to the development of the first-ever treatment for spinal muscular atrophy, or SMA, long known as the leading genetic cause of death among infants. Children who were expected to weaken until they could no longer even breathe on their own were instead learning to walk after receiving the drug.
This SciTech Now video includes scenes from a CSHL campus tour led by Jackie Novatt.
On that fateful Father鈥檚 Day, Novatt explained what causes SMA and how the drug addresses this, just as she normally would. The problem is with a process called RNA splicing, which is the focus of all of the work in Krainer Lab. She compares this complex genetic phenomenon to editing a word in different ways. During RNA splicing, the information in genes gets rearranged and repurposed in a way that鈥檚 like editing a word. She liked to use 鈥渃ataloging鈥� as an example. Chop off the 鈥渋ng鈥� and you get a related word, 鈥渃atalog.鈥� Or, 鈥渒eep chopping and you get 鈥榗at,鈥� which is a furry animal with whiskers that makes me sneeze,鈥� she adds with a laugh. But in SMA, the editing process of RNA splicing yields a nonsense word, in the same way you can get 鈥渓ogi鈥� from 鈥渃ataloging鈥� if you cut in the right spots.
It鈥檚 explanations like these that caught the attention of the LIU Pharmacy dean. At the end of the tour, he was 鈥渏ust kind of hovering鈥� as people made their way to their cars, Novatt remembers. When she asked if he had questions, his response was, 鈥測es, are you interested in a teaching job?鈥�
Today, Novatt is not only teaching as an assistant professor at LIU Pharmacy, but teaching a program that she designed. “I had this dream to be a lab professor collaborating with a real research lab, where instead of doing random experiments to throw them away, my students would learn laboratory techniques while doing something to contribute to an actual ongoing research project,鈥� she explains. Now, that is exactly what she鈥檚 doing.
Students in her course learn important techniques as they purify a particular protein that a research lab at the school needs in order to study HIV. Just like in the real world of science, the experiments don鈥檛 always work. But there are more than enough successes to make the endeavor worthwhile.