The has awarded 黑料吃瓜资源 (CSHL) Professor Adrian Krainer and his collaborator Paola Haeger Soto, an associate professor at the Universidad Cat贸lica del Norte in Chile, a $200,000 Innovation Fund grant. The researchers will investigate the biology behind fetal alcohol syndrome.
The Pew Innovation Fund encourages cross-disciplinary collaborations to tackle biological questions in new ways. The award supports collaborations between graduates of earlier-career Pew programs. Krainer was a Pew Biomedical Scholar, whereas his collaborator was a Pew Latin American Fellow. They are one of six pairs of researchers selected this year.
Krainer鈥檚 laboratory specializes in how RNA is processed after it is made. Proteins, the building blocks of every process in the body, begin in the DNA of our genes and are transcribed into strings of RNA. RNA is then refined by snipping out and reconnecting fragments into different arrangements, like old-fashioned movie film that is spliced together. These 鈥渟pliced鈥� RNAs are used as a template for making proteins. A wrong splice yields a bad protein. Krainer and his team study how RNA splicing is disturbed in various diseases.
Haeger Soto is a neuroscientist who studies fetal alcohol syndrome. Krainer says, 鈥淧aola found fetal alcohol syndrome is associated with changes in gene expression, particularly in RNA splicing. During the next two years, we will combine our efforts to identify key RNA splicing alterations associated with fetal alcohol syndrome and determine how they contribute to the condition.鈥�
Krainer鈥檚 and collaborators鈥� work has already led to the development of one therapy to treat a splicing disease鈥掷辫颈苍谤补锄补庐鈥攖o treat the neurodegenerative disease spinal muscular atrophy. He is hoping to apply a similar research methodology for treating fetal alcohol syndrome.
Written by: Luis Sandoval, Communications Specialist | [email protected] | 516-367-6826