x-ray crystallography Archives | ��ϳԹ��Դ

DNA replication: A game of precision

Jasmine Lee — Sun, 25 Apr 2021 13:00:40 +0000

Stretching out the DNA in all 46 chromosomes packed into one human cell would make a string of DNA two meters long. Accurately replicating all that DNA is vital to survival; cells must control this process with tremendous precision in time and space. Origin recognition complexes (ORCs) initiate the task of DNA replication throughout an...

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New tool for investigating brain cells, Parkinson’s, & more

Communications Department — Wed, 22 Jan 2020 14:15:46 +0000

Researchers have created a new chemical tool for revealing how specific types of brain cell receptors function in the brain. It’s an important step forward for studying Alzheimers, epilepsy, stroke, and even Parkinson’s disease.

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New tool for investigating brain cells, Parkinson’s, & more

Brian Stallard — Wed, 22 Jan 2020 10:00:53 +0000

NMDARs (N-methyl-D-aspartate receptors) serve as valves on nerve cells, controlling the flow of electrical signals in the brain. This special group of receptors is suspect in many neurological diseases, including Alzheimer’s, epilepsy, stroke, and Parkinson’s. Biologists from ��ϳԹ��Դ (CSHL) and chemists from the University of Bristol have joined forces, creating a chemical...

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One experiment: The shape of norovirus

Charlotte Hu — Fri, 25 Oct 2019 20:51:36 +0000

Viruses encapsulate their genetic cargo in a shell of proteins. These shells can form in various shapes and sizes. The shapes of the virus shells are important for developing vaccines against future viral infections. They provide target outlines of the virus for the immune system, which then creates a type of protein called antibodies that...

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Cryo-EM illuminates intricate designs of noroviruses

Charlotte Hu — Tue, 11 Jun 2019 20:00:56 +0000

In food-poisoning outbreaks, like those caused by noroviruses in hospitals, schools, restaurants and on cruise ships, infections occur and spread quickly. Also known as “stomach flu” and “winter vomiting bug,” noroviruses are the most common and extremely contagious breed of stomach bugs, accounting for 58% of all outbreaks in the United States and causing 685...

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Targeting ‘hidden pocket’ for treatment of stroke and seizure

Brian Stallard — Fri, 18 Jan 2019 21:50:15 +0000

Cold Spring Harbor, NY — The ideal drug is one that only affects the exact cells and neurons it is designed to treat, without unwanted side effects. This concept is especially important when treating the delicate and complex human brain. Now, scientists at ��ϳԹ��Դ have revealed a mechanism that could lead to...

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Portrait of a Neuroscience Powerhouse

Peter Tarr — Fri, 27 Apr 2018 16:07:30 +0000

At noon every Tuesday from September through June, scenes from a revolution in neuroscience are playing out at ��ϳԹ��Դ. Week after week, over 100 scientists cram themselves into a ground-floor meeting room in the Beckman Laboratory. It’s standing-room only as everyone in the Neuroscience Program settles in to hear details of the...

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45 years later, a scientist realizes he’s a star

Andrea Alfano — Wed, 24 Jan 2018 18:59:15 +0000

or decades, David Haas had all but forgotten about the crystal freezing technique he invented in the late 1960s for visualizing molecules. But while he was off working in the manufacturing industry, this technique was helping researchers develop drugs for HIV, among other diseases. It facilitated Nobel Prize-winning advances including cryo-electron microscopy, which won the...

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Research profile: Leemor Joshua-Tor

Peter Tarr — Mon, 27 Nov 2017 18:24:48 +0000

When she was in the 7th grade, Leemor Joshua-Tor came upon a fragrant box that once held her mother’s perfume. It proved the perfect container for a set of flashcards that she was using to learn properties of the chemical elements. “I think my brain connected doing chemistry to good feelings, good smells,” she muses...

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Freeze-frames of enzymes in action have implications for a new cancer treatment concept

Peter Tarr — Mon, 03 Jul 2017 11:00:32 +0000

Tutases are a class of enzymes that regulate the microRNA let-7—a gene that is commonly downregulated in cancers. The Joshua-Tor lab used x-ray crystallography to capture images of the enzyme in action, offering insight into how these potential cancer targets function.

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CSHL’s Dr. Leemor Joshua-Tor is elected to The National Academy of Sciences

Communications Department — Tue, 02 May 2017 13:55:33 +0000

Washington, D.C. and Cold Spring Harbor, NY — ��ϳԹ��Դ Professor Leemor Joshua-Tor, Ph.D., a structural biologist whose work is known and respected worldwide, has been elected to The National Academy of Sciences (NAS). Dr. Joshua-Tor, who since 2008 has been an Investigator of the Howard Hughes Medical Institute, joins a new class whose...

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Protein complex that takes first steps in human DNA replication dance is captured at high atomic resolution

Peter Tarr — Thu, 16 Mar 2017 16:19:54 +0000

The Stillman and Joshua-Tor labs collaborated to obtain the structure of the active human Origin Recognition Complex (ORC), the proteins that control the initiation of DNA replication. Using both cyro-EM and x-ray crystallography, the labs obtained a high-resolution image of the ORC proteins bound to DNA, providing insights into the most fundamental process in cell proliferation.

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New art supplies for visualizing tiny machines in the brain

Andrea Alfano — Wed, 01 Mar 2017 18:57:17 +0000

Neuron." data-description="" />An unusual, but beautiful sight can be found among the figures of a recent scientific paper about some of the tiny machines in our brain: watercolor paintings by Annabel Romero Hernandez, who just graduated from CSHL’s Watson School of Biological Sciences. taring intently at a watercolor painting of what might be mistaken for a bouquet...

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Detailed images of NMDA receptor show how zinc and a potential drug affect its function

Peter Tarr — Thu, 01 Dec 2016 12:00:26 +0000

Drugs precisely targeting portions of this receptor may have applications in Alzheimer’s, depression and schizophrenia Cold Spring Harbor, NY — The difference between mental health and mental illness can turn on changes in brain cells and their connections that are almost incomprehensibly tiny, at least in physical terms. This irony is brought to light by...

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In a role reversal, RNAs proofread themselves

Communications Department — Thu, 29 Jan 2015 15:35:43 +0000

Molecular photographs of an enzyme bound to RNA reveal a new, inherent quality control mechanism Cold Spring Harbor, NY — Building a protein is a lot like a game of telephone: information is passed along from one messenger to another, creating the potential for errors every step of the way. There are separate, specialized enzymatic...

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RNA and U with fifth-year student Jack Walleshauser

Communications Department — Wed, 10 Dec 2014 22:20:07 +0000

Each year at the end of November, ��ϳԹ��Դ holds its annual in-house symposium. The labs present their research to the whole CSHL community. PIs give talks. Students and postdocs present posters. There are many great reasons to participate in the poster session: the excitement of telling lots of scientists about your research, the free...

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Knowing what to keep and what to trash: How an enzyme distinguishes cellular messages

Communications Department — Sun, 03 Aug 2014 13:00:00 +0000

Molecular structure reveals how a protein reads RNAs to preserve stem cell identity Cold Spring Harbor, NY — Every once in a while, we are forced to sort that stack of papers on the kitchen counter. Interspersed between the expired coupons and dozens of takeout menus are important documents like your car insurance or electric...

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Biologists characterize enzymatic identity of key player in generating genome-protecting piRNAs

Peter Tarr — Thu, 11 Oct 2012 19:35:36 +0000

Cold Spring Harbor, NY — Scientists at ��ϳԹ��Դ (CSHL) have made important progress in understanding the earliest steps in a process that protects animal genomes from potentially dangerous genetic elements called transposons. If left unchecked, these genomic parasites can run rampant and cause sterility. The laboratories of CSHL Professors Gregory J. Hannon...

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CSHL team solves a protein complex’s molecular structure to explain its role in gene silencing

Communications Department — Mon, 14 Nov 2011 14:43:02 +0000

The Joshua-Tor lab and colleagues determined how the three components of the RNA-Induced Initiation of Transcriptional gene Silencing (RITS) interact with each other, offering insight into the establishment of heterochromatin and gene silencing.

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CSHL structural biologists reveal novel drug binding site in NMDA receptor subunit

Peter Tarr — Thu, 16 Jun 2011 13:56:20 +0000

Precisely mapped allosteric binding site will facilitate design of drugs with minimal side effects Cold Spring Harbor, NY — Structural biologists at ��ϳԹ��Դ (CSHL) have obtained a precise molecular map of the binding site for an allosteric inhibitor in a subtype of the NMDA (N-methyl-D-aspartate) receptor, which is commonly expressed in brain...

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x-ray crystallography Archives | ���ϳԹ���Դ

DNA replication: A game of precision

New tool for investigating brain cells, Parkinson’s, & more

New tool for investigating brain cells, Parkinson’s, & more

One experiment: The shape of norovirus

Cryo-EM illuminates intricate designs of noroviruses

Targeting ‘hidden pocket’ for treatment of stroke and seizure

Portrait of a Neuroscience Powerhouse

45 years later, a scientist realizes he’s a star

Research profile: Leemor Joshua-Tor

Freeze-frames of enzymes in action have implications for a new cancer treatment concept

CSHL’s Dr. Leemor Joshua-Tor is elected to The National Academy of Sciences

Protein complex that takes first steps in human DNA replication dance is captured at high atomic resolution

New art supplies for visualizing tiny machines in the brain

Detailed images of NMDA receptor show how zinc and a potential drug affect its function

In a role reversal, RNAs proofread themselves

RNA and U with fifth-year student Jack Walleshauser

Knowing what to keep and what to trash: How an enzyme distinguishes cellular messages

Biologists characterize enzymatic identity of key player in generating genome-protecting piRNAs

CSHL team solves a protein complex’s molecular structure to explain its role in gene silencing

CSHL structural biologists reveal novel drug binding site in NMDA receptor subunit

x-ray crystallography Archives | ��ϳԹ��Դ