Stanley Institute for Cognitive Genomics Archives | ��ϳԹ��Դ

Detailed images of NMDA receptor show how zinc and a potential drug affect its function

Peter Tarr — Thu, 01 Dec 2016 12:00:26 +0000

Drugs precisely targeting portions of this receptor may have applications in Alzheimer’s, depression and schizophrenia Cold Spring Harbor, NY — The difference between mental health and mental illness can turn on changes in brain cells and their connections that are almost incomprehensibly tiny, at least in physical terms. This irony is brought to light by...

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Was it better or worse than you expected? Your basal ganglia know – so you can act accordingly

Peter Tarr — Wed, 21 Sep 2016 13:01:44 +0000

Identifying a neural circuit that processes evaluations, with implications for understanding depression Cold Spring Harbor, NY — You make reservations at a restaurant, expecting the food to be good. If the meal turns out to be superb—even better than expected—that’s information you will want to remember, so you can go back again. The reverse applies...

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Innovative tools will shed clarifying light on inhibitory neurons

Communications Department — Wed, 21 Sep 2016 13:00:06 +0000

Cold Spring Harbor, NY — Imagine if every time you got in your car, you fired it up, put it in drive, slammed on the gas, and didn’t let up until you reached your destination. Now imagine every driver on the road did the same thing. It would be pile up after pile up. A...

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Our brain uses statistics to calculate confidence, make decisions

Communications Department — Wed, 04 May 2016 12:00:48 +0000

The brain produces feelings of confidence that inform decisions the same way statistics pulls patterns out of noisy data Cold Spring Harbor, NY — The directions, which came via cell phone, were a little garbled, but as you understood them: “Turn left at the 3rd light and go straight; the restaurant will be on your...

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First structural views of the NMDA receptor in action will aid drug development

Communications Department — Mon, 02 May 2016 11:00:26 +0000

Cold Spring Harbor, NY — Structural biologists at ��ϳԹ��Դ (CSHL) and Janelia Research Campus/HHMI, have obtained snapshots of the activation of an important type of brain-cell receptor. Dysfunction of the receptor has been implicated in a range of neurological illnesses, including Alzheimer’s disease, Parkinson’s disease, depression, seizure, schizophrenia, autism, and injuries related...

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CSHL scientists Bo Li and Je Lee win HFSP Research Grant awards

Communications Department — Tue, 12 Apr 2016 15:03:41 +0000

Cold Spring Harbor, NY — Two scientists, both leaders of research labs at ��ϳԹ��Դ (CSHL), are among 25 teams that have won Human Frontier Science Program (HFSP) Research Program Grants for 2016. The awards were announced by the International Human Frontier Science Program Organization (HFSPO), based in Strasbourg, France. The two CSHL...

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Discovery of a new X-linked intellectual disability syndrome is aided by web communication tools

Peter Tarr — Thu, 03 Dec 2015 12:00:07 +0000

TAF1 gene is located. Lyon and colleagues discovered that this gene is mutated in all patients with the newly described TAF1 syndrome. Image courtesy Wikimedia Commons." data-description="" />Cold Spring Harbor, NY — It’s a genetic detective story with a distinct 21st-century flavor. A geneticist from ��ϳԹ��Դ (CSHL) in the United States has used powerful internet and social media tools to find doctors and researchers in nine U.S. states and eight other nations to help him confirm, document and describe in...

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Surprised? Cholinergic neurons send brain-wide broadcasts enabling us to learn from the unexpected

Communications Department — Tue, 25 Aug 2015 15:42:04 +0000

Cold Spring Harbor, NY — When a large combat unit, widely dispersed in dense jungle, goes to battle, no single soldier knows precisely how his actions are affecting the unit’s success or failure. But in modern armies, every soldier is connected via an audio link that can instantly receive broadcasts—reporting both positive and negative surprises—based...

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Drs. Kepecs and Li honored with 2015 NARSAD Independent Investigator grant awards

Communications Department — Tue, 12 May 2015 15:20:33 +0000

Cold Spring Harbor, NY — Two neuroscientists at ��ϳԹ��Դ (CSHL) have been awarded prestigious NARSAD Independent Investigator grants. The announcement was made by the New York City-based Brain and Behavior Research Foundation (BBRF). Adam Kepecs, Ph.D., and Bo Li, Ph.D., both CSHL associate professors, were among 40 mid-career scientists from 30 institutions in...

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Scientists discover important communication mechanism between two brain areas implicated in schizophrenia

Communications Department — Tue, 07 Apr 2015 20:00:00 +0000

Disruptions in an inhibitory brain circuit between the thalamus and prefrontal cortex may underlie cognitive disorders such as schizophrenia Cold Spring Harbor, NY — The prefrontal cortex (PFC) plays an important role in cognitive functions such as attention, memory and decision-making. Faulty wiring between PFC and other brain areas is thought to give rise to...

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A new brain circuit that controls fear is identified

Communications Department — Mon, 19 Jan 2015 11:00:13 +0000

Researchers discover a pathway in that mouse brain that regulates fear memory and behavior Cold Spring Harbor, NY — Some people have no fear, like that 17-year-old kid who drives like a maniac. But for the nearly 40 million adults who suffer from anxiety disorders, an overabundance of fear rules their lives. Debilitating anxiety prevents...

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Imaging method linking brainwide cell activation & behavior shows what it means for mice to have sex in mind

Peter Tarr — Mon, 05 Jan 2015 12:48:24 +0000

Automated method detects activity of neurons during specific behaviors, brain-wide, at cellular resolution Cold Spring Harbor, NY — Most people have seen fMRI scans of the human brain. These use a technology called functional magnetic resonance imaging to identify portions of the brain that are active while a subject is being scanned. Fuzzy, ill-defined areas...

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Neuronal circuits filter out distractions in the brain

Communications Department — Mon, 15 Dec 2014 11:26:17 +0000

Scientists identify a neural pathway that controls attention, with implications for psychiatric disorders Cold Spring Harbor, NY — The next time you are in a crowded room, or a meeting, or even at the park with your kids, take a look around. How many people are on their phone? Distractions invade every aspect of our...

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4 CSHL scientists will contribute to President’s BRAIN Initiative under new NIH grants

Peter Tarr — Tue, 30 Sep 2014 10:39:41 +0000

Cold Spring Harbor, NY — Four scientists at ��ϳԹ��Դ (CSHL) will perform research in President Obama’s BRAIN Initiative under two new CSHL grants announced in Washington today. The CSHL grants are among more than 100 issued by the National Institutes of Health (NIH), totaling $46 million for the 2014-15 fiscal year. They...

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A shift in the code: New method reveals hidden genetic landscape

Communications Department — Mon, 18 Aug 2014 14:33:24 +0000

Scientists develop algorithm to uncover genomic insertions and deletions involved in autism, OCD Cold Spring Harbor, NY — With three billion letters in the human genome, it seems hard to believe that adding a DNA base here or removing a DNA base there could have much of an effect on our health. In fact, such...

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Unprecedented detail of intact neuronal receptor offers blueprint for drug developers

Communications Department — Thu, 29 May 2014 06:28:00 +0000

NMDA receptor malfunction is implicated in Alzheimer’s, Parkinson’s, depression, schizophrenia, autism, and stroke Cold Spring Harbor, NY — Biologists at ��ϳԹ��Դ (CSHL) report today that they have succeeded in obtaining an unprecedented view of a type of brain-cell receptor that is implicated in a range of neurological illnesses, including Alzheimer’s disease, Parkinson’s...

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Dealing with stress—to cope or to quit?

Communications Department — Tue, 27 May 2014 22:10:00 +0000

Researchers identify neurons that determine whether an individual will be depressed or resilient Cold Spring Harbor, NY — We all deal with stress differently. For many of us, stress is a great motivator, spurring a renewed sense of vigor to solve life’s problems. But for others, stress triggers depression. We become overwhelmed, paralyzed by hopelessness...

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Research sees overlap in altered genes found in schizophrenia, autism and intellectual disability

Peter Tarr — Mon, 28 Apr 2014 06:28:00 +0000

Dublin, Ireland and Cold Spring Harbor, NY — In research published today in Molecular Psychiatry, a multinational team of scientists presents new evidence supporting the theory that in at least some cases of schizophrenia, autism and intellectual disability (ID), malfunctions in some of the same genes are contributing to pathology. The team, the product of...

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Scientists discover a new pathway for fear deep within the brain

Communications Department — Wed, 12 Feb 2014 00:00:13 +0000

‘Far-reaching’ neurons connect the amygdala with fear response center to control behavior Cold Spring Harbor, NY — Fear is primal. In the wild, it serves as a protective mechanism, allowing animals to avoid predators or other perceived threats. For humans, fear is much more complex. A normal amount keeps us safe from danger. But in...

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Team demonstrates power of precision medicine in successful treatment of patient with disabling OCD

Peter Tarr — Thu, 03 Oct 2013 08:00:50 +0000

Cold Spring Harbor, NY — A multidisciplinary team led by a geneticist and psychiatrist from ��ϳԹ��Դ’s (CSHL) Stanley Institute for Cognitive Genomics today publish a paper providing a glimpse of both the tremendous power and the current limitations of what is sometimes called “precision medicine.” Precision medicine is an approach to diagnosis...

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Stanley Institute for Cognitive Genomics Archives | ���ϳԹ���Դ