Scott Lowe Archives | ��ϳԹ��Դ

A fellowship of curiosity

Communications Department — Tue, 26 May 2026 16:00:56 +0000

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Her science could help you live healthier, longer

Margaret Osborne — Mon, 17 Nov 2025 12:30:51 +0000

When Corina Amor Vegas was just 7 years old, her mother, Esperanza, was diagnosed with breast cancer. Esperanza’s treatment would take over a decade. However, after participating in a clinical trial for a new cancer drug, she entered remission. Today, Amor Vegas is happy to say her mother is doing “very well.” The clinical trial...

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Zombie cells: The intersection of cancer and aging

Communications Department — Tue, 01 Jul 2025 11:30:13 +0000

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Clusters of cooperating tumor-suppressor genes are found in large regions deleted in common cancers

Communications Department — Mon, 07 May 2012 15:56:25 +0000

Michael Wigler, in collaboration with Alexander Krasnitz, James Hicks and Scott Powers, used a new computational method called CORES to propose an alternative to the “two-hit” hypothesis to explain how cancers arise.

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CSHL scientists reveal mechanism behind ‘oncogene addiction’ in acute leukemia

Peter Tarr — Fri, 29 Jul 2011 19:16:21 +0000

Fusion oncoprotein MLL-AF9 ‘hijacks’ Myb to enforce a program of aberrant self-renewal Cold Spring Harbor, NY — A team of scientists at ��ϳԹ��Դ (CSHL) has laid bare the mechanism behind a phenomenon called oncogene addiction in mice suffering from a form of leukemia that mimics acute myelogenous leukemia (AML) in humans. Significantly,...

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CSHL team perfects non-lethal way of switching off essential genes in mice

Communications Department — Wed, 13 Apr 2011 15:19:54 +0000

Cold Spring Harbor, NY — One way of discovering a gene’s function is to switch it off and observe how the loss of its activity affects an organism. If a gene is essential for survival, however, then switching it off permanently will kill the organism before the gene’s function can be determined. Researchers at Cold Spring...

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Researchers identify therapeutic target for liver cancer and a predictive biomarker of response

Communications Department — Mon, 14 Mar 2011 17:00:00 +0000

FGF19 protein dramatically decreases tumor growth in mice" data-description="" />The research points to a clear strategy for identifying the subset of liver cancer patients who might benefit from treatment with a therapeutic monoclonal antibody. Cold Spring Harbor, NY — In a research study appearing in the journal Cancer Cell on March 14, scientists from ��ϳԹ��Դ (CSHL) and four other institutions have identified...

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New method powerfully boosts efficiency of RNA interference (RNAi) in shutting down genes

Communications Department — Thu, 24 Feb 2011 19:05:32 +0000

CSHL-led team finds an accurate, scalable way to identify potent RNAi triggers for biological studies and for RNA therapeutics Cold Spring Harbor, NY — A research team led by scientists at ��ϳԹ��Դ (CSHL) has developed a powerful method that allows them to sift through thousands of candidate hairpin-shaped RNA molecules at a time...

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��ϳԹ��Դ team shows how loss of key protein promotes aggressive form of leukemia

Peter Tarr — Thu, 01 Jul 2010 21:19:32 +0000

p53 loss promotes acute myeloid leukemia (AML) by enabling aberrant self-renewal of myeloid precursors Cold Spring Harbor, NY — New research by scientists at ��ϳԹ��Դ (CSHL) has illuminated in fine detail one of the genetic paths that leads to a particularly aggressive form of leukemia. CSHL Professor Scott W. Lowe, Ph.D., an...

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CSHL scientists discover how a tumor suppressor gene induces cellular senescence and staves off cancer

Communications Department — Tue, 13 Apr 2010 20:52:50 +0000

The tumor suppressor Retinoblastoma (RB) represses DNA replication genes during senescence Cold Spring Harbor, NY — A frequently mutated gene in human cancers is the retinoblastoma (RB) gene, which controls a potent tumor suppression pathway. Mutations in the gene disable the vast and intricate RB pathway in virtually all tumor cells, leading to disturbances in...

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CSHL study shows that malignant tumors can be shut down after all

Communications Department — Mon, 09 Nov 2009 14:39:23 +0000

Aggressive tumors lacking p53 protein stop dead in their tracks when p53’s sister protein—TAp63—steps in Cold Spring Harbor, NY — Oncologists have had their hands tied because more than half of all human cancers have mutations that disable a protein called p53. As a critical anti-cancer watchdog, p53 masterminds several cancer-fighting operations within cells. When...

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Using RNAi-based technique, CSHL scientists find new tumor suppressor genes in lymphoma

Peter Tarr — Fri, 09 Oct 2009 14:52:14 +0000

in vivo RNAi screen in the Eμ-Myc lymphoma model." data-description="" />Discovery reveals gene activity networks that let tumors thrive and suggests new modes of therapy Cold Spring Harbor, NY — Researchers from ��ϳԹ��Դ (CSHL) have uncovered a large, new cache of genes that act as built-in barriers against cancer. Known as tumor suppressors, the newly identified genes and the insight that they...

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CSHL thanks the Don Monti Memorial Research Foundation for $500,000 contribution in support of leading-edge cancer research

Dagnia Zeidlickis — Tue, 05 May 2009 15:48:59 +0000

Cold Spring Harbor, NY — A growing partnership between ��ϳԹ��Դ (CSHL) and the Don Monti Memorial Research Foundation has been significantly strengthened. The Foundation, based in Cold Spring Harbor, New York, has donated $500,000 to CSHL’s cancer genetics research program. The funds will support research that is the basis for the development of...

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CSHL team develops mouse models of leukemia that accurately predict response to chemotherapy

Peter Tarr — Wed, 01 Apr 2009 17:27:26 +0000

p53 gene network is key determinant of response; its attenuation causes drug resistance Cold Spring Harbor, NY — Being able to accurately predict how a given cancer will respond to chemotherapy would spare patients with non-responsive tumors the burden of dealing with a toxic and ultimately unhelpful treatment. Just as important, knowing which of a patient’s...

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Three studies by ��ϳԹ��Դ scientists appear in the latest issue of Cell

Peter Tarr — Wed, 26 Nov 2008 18:24:18 +0000

Cold Spring Harbor, NY — Three separate research teams, each led by faculty at ��ϳԹ��Դ (CSHL), report results in the journal Cell on Nov. 26. It is unusual for multiple, unrelated studies emanating from the same institution to appear in a single issue of the prestigious journal, which typically publishes 10 to...

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Science teams at ��ϳԹ��Դ identify 13 new tumor-suppressor genes in liver cancer

Communications Department — Mon, 17 Nov 2008 18:30:20 +0000

A powerful new approach to validate linkages between suspect genes and their functional contributions to cancer Cold Spring Harbor, NY — Over the years, hunting for cancer-related genes and understanding how they work has been an important, although time-consuming, exercise. At ��ϳԹ��Դ (CSHL), five different research groups have now combined their expertise...

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Senescence in liver cells is found by CSHL Scientists to help limit acute tissue damage

Peter Tarr — Thu, 21 Aug 2008 18:54:24 +0000

Studies in living mice demonstrate senescent liver cells can provoke a beneficial immune reaction Cold Spring Harbor, NY — Although post-reproductive life in humans is often associated with decline and a loss of powers, an analogous state in certain cells—called senescence—is proving to be one of ironic potency. Scientists at ��ϳԹ��Դ (CSHL)...

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CSHL scientists correlate enzyme expression levels with chemotherapy drug response

Communications Department — Fri, 18 Jul 2008 19:00:01 +0000

A method that could be applied widely to explore genetic basis of cancer drug resistance Cold Spring Harbor, NY — Why do cancer patients develop resistance to chemotherapy drugs, sometimes abruptly, after a period in which the drugs seem to be working well to reduce tumors or hold them in check? Although largely a mystery to...

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CSHL scientists trace causal link between a tumor suppressor gene and liver cancer

Communications Department — Mon, 02 Jun 2008 19:07:59 +0000

DLC1 is likely altered in many human cancers and points to new drug targets Cold Spring Harbor, NY — Scientists at ��ϳԹ��Դ (CSHL) have taken the search for cancer-causing genes an important step forward. In a newly published paper, they confirm that a gene called DLC1 is a tumor suppressor. They have...

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The Don Monti Foundation awards $500,000 grant to ��ϳԹ��Դ

Communications Department — Fri, 25 Apr 2008 19:24:22 +0000

Grant to provide Cutting-Edge DNA-Sequencing Equipment Cold Spring Harbor, NY — The Don Monti Memorial Research Foundation recently awarded a $500,000 grant to support ��ϳԹ��Դ (CSHL) professor Scott Lowe’s Leukemia Research. The funds will be used to purchase a Genome Analyzer System, for use in the Tita Monti Cancer Research Laboratory. Cancer...

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Scott Lowe Archives | ���ϳԹ���Դ