schizophrenia Archives | ��ϳԹ��Դ

Mind-blowing neuroscience research

Communications Department — Tue, 22 Jul 2025 11:30:19 +0000

The brain is the most complex and powerful part of the human body. When things are working as they should, we don’t notice at all. However, any number of conditions can disrupt healthy brain function. ��ϳԹ��Դ (CSHL) neuroscientists focus on understanding how neural connections in the brain translate into behavior. Their research...

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At the Lab: Dancing with fire

Communications Department — Tue, 29 Apr 2025 11:30:50 +0000

It can cause blackouts, memory loss, and hallucinations. It’s typically diagnosed in people in their 20s and considered more common among women than men. It’s not schizophrenia, but it can be misdiagnosed as such. This week At the Lab, CSHL Professor Hiro Furukawa returns to speak about anti-NMDAR encephalitis, an autoimmune disease discovered less than...

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Cocktails & Chromosomes: Hormones on my mind

Communications Department — Wed, 09 Apr 2025 11:30:14 +0000

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Putting out a brain on fire

Jen A. Miller — Thu, 17 Oct 2024 11:30:47 +0000

Imagine you wake up in a hospital without a single memory of the last month. Doctors say you had a series of violent episodes and paranoid delusions. You’d become convinced you were suffering from bipolar disorder. Then, after a special test, a neurologist diagnoses you with a rare autoimmune disease called anti-NMDAR encephalitis. This is...

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At the Lab Episode 2: Molecular puppetry

Communications Department — Tue, 09 Apr 2024 11:30:36 +0000

It’s easy to think of your brain as your body’s puppet master. This week At the Lab, we speak with CSHL Professor Hiro Furukawa, who studies a part of the brain that actually does work a lot like a puppeteer. Hear how Furukawa figured out the puppet master’s routine. And find out what that might...

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A new look at brain function and psychiatric disorders

Jennifer Michalowski — Wed, 02 Nov 2022 11:30:23 +0000

New images from scientists at ��ϳԹ��Դ (CSHL) reveal for the first time the three-dimensional structures of a set of molecules critical for healthy brain function. The molecules are members of a family of proteins in the brain known as NMDA receptors, which mediate the passage of essential signals between neurons. The detailed...

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The unexpected cells helping to shape young brains

Jennifer Michalowski — Wed, 28 Sep 2022 17:30:26 +0000

When the brain first wires itself up in early development, it creates more connections than it actually needs. Some of these connections, or synapses, will transmit critical signals as young animals begin to sense their surroundings. Others will be eliminated as the brain matures. Only those that the animal needs to understand and interact with...

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Mapping out new routes to treat brain disorders

Daniel Dunaief — Fri, 10 Jun 2022 14:00:01 +0000

��ϳԹ��Դ (CSHL) Professor Hiro Furukawa takes an architectural approach to brain research. He creates structural 3D maps of important proteins that malfunction in brain disorders. Furukawa has zeroed in on a protein called the NMDA (for N-methyl-D-aspartate) receptor that plays a key role in learning and memory. The NMDA receptor acts as...

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Uncovering how immune cells nurture brain connections

Communications Department — Mon, 07 Mar 2022 20:00:54 +0000

Microglia, the immune cells of the brain, are known for eating up unwanted items like germs and debris, much as their counterparts do in the rest of the body. In early childhood, certain microglia remove unneeded connections, or synapses, to shape the adult brain’s organized circuitry. Now, ��ϳԹ��Դ (CSHL) Professor Linda Van...

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Are you sure you heard that sound?

Jasmine Lee — Wed, 14 Apr 2021 13:00:37 +0000

A new study from ��ϳԹ��Դ (CSHL) Research Investigator Katharina Schmack and Adjunct Professor Adam Kepecs uncovered how hallucinations are produced in human and mouse brains. Their new mouse model for hallucination-like behaviors should help uncover mechanisms and treatments for schizophrenia. Schmack was working as a psychiatrist at the Charité–Universitätsmedizin Berlin studying psychosis...

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Brain receptor pulls open electrical gate like a puppet master

Communications Department — Tue, 30 Jun 2020 15:09:08 +0000

For the first time, researchers in the lab of CSHL Professor Hiro Furukawa have been able to track each atom in the NMDA receptor, an important brain protein, as it transmits or inhibits neural signals. Critical for brain development and function, the receptor converts chemical messages between cells into electrical signals within a neuron. The...

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How chandelier cells light up the brain

Jennifer Michalowski — Thu, 18 Jun 2020 15:00:51 +0000

Within the intricate network of cells that make up the brain, chandelier cells stand out for their elaborate, branching structure. With an elegant shape similar to that of its namesake, a single chandelier cell reaches out to connect and communicate with more than 100 other neurons. Abnormalities in chandelier cells have been linked to epilepsy,...

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Interview with a neuroscientist

Charlotte Hu — Fri, 31 May 2019 13:18:26 +0000

Comprised of a M.C. Escher-esque network of pathways, the brain is a maze of chaotic proportions. In its full-functioning glory, the brain helps us move, think, dream, and create. It’s a beautiful marvel of evolution that coordinates and translates messages from cells into emotions, memories, and actions. But what happens in the brain when its...

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Brain, interrupted

Charlotte Hu — Fri, 31 May 2019 13:09:13 +0000

{“questions”:{“nk5k0”:{“id”:”nk5k0″,”mediaType”:”image”,”answerType”:”text”,”imageCredit”:”Edvard Munch ‘The Scream'”,”image”:”https:\/\/www.cshl.edu\/wp-content\/uploads\/2019\/05\/The_Scream-Edvard-Munch.jpg”,”imageId”:”28655″,”video”:””,”imagePlaceholder”:””,”imagePlaceholderId”:””,”title”:”In a normal brain, we have a programmed response to a threatening situation. In a brain riddled with anxiety, that normal program is overriden. These reactionary responses are processed in a part of the brain that codes emotions, called the:”,”desc”:”The amygdala is the brain\u2019s seat of emotion, otherwise known as the alarm...

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How key brain receptor works in hostile conditions

Communications Department — Wed, 09 May 2018 19:38:59 +0000

Cold Spring Harbor, NY — During a stroke or an epileptic seizure, neurons in affected parts of the brain fire at an abnormally rapid rate. One byproduct of this condition is that the pH of the brain drops markedly, rendering the local environment inhospitably acidic. Using a powerful microscopy method called cryo-EM, biologists at Cold...

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Portrait of a Neuroscience Powerhouse

Peter Tarr — Fri, 27 Apr 2018 16:07:30 +0000

At noon every Tuesday from September through June, scenes from a revolution in neuroscience are playing out at ��ϳԹ��Դ. Week after week, over 100 scientists cram themselves into a ground-floor meeting room in the Beckman Laboratory. It’s standing-room only as everyone in the Neuroscience Program settles in to hear details of the...

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Detailed images of NMDA receptor show how zinc and a potential drug affect its function

Peter Tarr — Thu, 01 Dec 2016 12:00:26 +0000

Drugs precisely targeting portions of this receptor may have applications in Alzheimer’s, depression and schizophrenia Cold Spring Harbor, NY — The difference between mental health and mental illness can turn on changes in brain cells and their connections that are almost incomprehensibly tiny, at least in physical terms. This irony is brought to light by...

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Innovative tools will shed clarifying light on inhibitory neurons

Communications Department — Wed, 21 Sep 2016 13:00:06 +0000

Cold Spring Harbor, NY — Imagine if every time you got in your car, you fired it up, put it in drive, slammed on the gas, and didn’t let up until you reached your destination. Now imagine every driver on the road did the same thing. It would be pile up after pile up. A...

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Thinking about cognition with recent graduate Kristen Delevich

Communications Department — Wed, 08 Apr 2015 22:44:52 +0000

“I’ve been getting quite good at preparing acute olfactory bulb slices, if I do say so myself.” Recent Watson School graduate Kristen Delevich has been keeping us entertained and informed about her scientific life, as well as what’s exciting and controversial in the field of systems neuroscience, with her tweets. We read about the progress of...

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Scientists discover important communication mechanism between two brain areas implicated in schizophrenia

Communications Department — Tue, 07 Apr 2015 20:00:00 +0000

Disruptions in an inhibitory brain circuit between the thalamus and prefrontal cortex may underlie cognitive disorders such as schizophrenia Cold Spring Harbor, NY — The prefrontal cortex (PFC) plays an important role in cognitive functions such as attention, memory and decision-making. Faulty wiring between PFC and other brain areas is thought to give rise to...

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schizophrenia Archives | ���ϳԹ���Դ