research highlights Archives | ��ϳԹ��Դ

The next evolution of AI begins with ours

Samuel Diamond — Mon, 25 Nov 2024 12:30:54 +0000

In a sense, each of us begins life ready for action. Many animals perform amazing feats soon after they’re born. Spiders spin webs. Whales swim. But where do these innate abilities come from? Obviously, the brain plays a key role as it contains the trillions of neural connections needed to control complex behaviors. However, the...

The post The next evolution of AI begins with ours appeared first on ��ϳԹ��Դ.

Vitamin K supplement slows prostate cancer in mice

Jen A. Miller — Thu, 24 Oct 2024 18:00:34 +0000

Science, shows that menadione significantly slows prostate cancer growth in mice and in human-derived cancer cells, as seen here." data-description="" />Prostate cancer is a quiet killer. In most men, it’s treatable. However, in some cases, it resists all known therapies and turns extremely deadly. A new discovery at ��ϳԹ��Դ (CSHL) points to a potentially groundbreaking solution. CSHL Professor Lloyd Trotman’s lab has found that the pro-oxidant supplement menadione slows prostate cancer progression...

The post Vitamin K supplement slows prostate cancer in mice appeared first on ��ϳԹ��Դ.

Putting out a brain on fire

Jen A. Miller — Thu, 17 Oct 2024 11:30:47 +0000

Imagine you wake up in a hospital without a single memory of the last month. Doctors say you had a series of violent episodes and paranoid delusions. You’d become convinced you were suffering from bipolar disorder. Then, after a special test, a neurologist diagnoses you with a rare autoimmune disease called anti-NMDAR encephalitis. This is...

The post Putting out a brain on fire appeared first on ��ϳԹ��Դ.

Corn’s ‘missing link’

Margaret Osborne — Wed, 07 Aug 2024 15:00:25 +0000

Teosinte Pollen Drive (TPD) is a selfish genetic system in maize-teosinte hybrids, which allows only pollen with both toxin and antidote to survive. Here, we see the pollen-producing part of the maize-teosinte hybrid. Image: Jon Cahn/Martienssen lab" data-description="" />��ϳԹ��Դ (CSHL) has begun to unravel a mystery millennia in the making. Our story begins 9,000 years ago. It was then that maize was first domesticated in the Mexican lowlands. Some 5,000 years later, the crop crossed with a species from the Mexican highlands called teosinte mexicana. This resulted in cold adaptability....

The post Corn’s ‘missing link’ appeared first on ��ϳԹ��Դ.

Every rose has its thorns … or does it?

Margaret Osborne — Thu, 01 Aug 2024 18:00:23 +0000

According to Greek mythology, red roses first appeared when Aphrodite pricked her foot on a thorn, spilling blood on a white rose. Since then, roses’ thorns have captured the imaginations of countless poets and forlorn lovers. But they aren’t the only plants with these dangerous protrusions, technically called prickles. Prickles have evolved independently in species...

The post Every rose has its thorns … or does it? appeared first on ��ϳԹ��Դ.

A link between breast changes and . . . UTIs?

Jennifer Michalowski — Thu, 02 May 2024 11:30:55 +0000

Women’s health is often talked about in terms of major, life-altering events like pregnancy and menopause. A new study from ��ϳԹ��Դ (CSHL) underscores the importance of considering everyday occurrences’ impact on women’s well-being. CSHL researchers have made a surprising discovery involving urinary tract infections (UTIs). The scientists found that UTIs in mice...

The post A link between breast changes and . . . UTIs? appeared first on ��ϳԹ��Դ.

Why some RNA drugs work better than others

Jennifer Michalowski — Wed, 06 Mar 2024 12:30:20 +0000

Spinal muscular atrophy, or SMA, is the leading genetic cause of infant death. Less than a decade ago, ��ϳԹ��Դ (CSHL) Professor Adrian Krainer showed this brutal disease can be treated by tweaking a process called RNA splicing. This breakthrough resulted in Spinraza, the first effective treatment for SMA. It also opened a...

The post Why some RNA drugs work better than others appeared first on ��ϳԹ��Դ.

Pancreatic cancer lives on mucus

Luis Sandoval — Wed, 28 Feb 2024 12:30:22 +0000

Knowing exactly what’s inside a tumor can maximize our ability to fight cancer. But that knowledge doesn’t come easy. Tumors are clusters of constantly changing cancer cells. Some become common cancer variants. Others morph into deadlier, drug-resistant varieties. No one truly understands what governs this chaotic behavior. Now, ��ϳԹ��Դ (CSHL) Professor David...

The post Pancreatic cancer lives on mucus appeared first on ��ϳԹ��Դ.

Chronic stress spreads cancer … here’s how

Margaret Osborne — Thu, 22 Feb 2024 16:00:10 +0000

Stress is inevitable. But too much of it can be terrible for our health. Chronic stress can increase our risk for heart disease and strokes. It may also help cancer spread. How this works has remained a mystery—a challenge for cancer care. Xue-Yan He, a former postdoc in ��ϳԹ��Դ (CSHL) Adjunct Professor...

The post Chronic stress spreads cancer … here’s how appeared first on ��ϳԹ��Դ.

The fountain of youth is … a T cell?

Luis Sandoval — Wed, 24 Jan 2024 10:00:45 +0000

The fountain of youth has eluded explorers for ages. It turns out the magic anti-aging elixir might have been inside us all along. ��ϳԹ��Դ (CSHL) Assistant Professor Corina Amor Vegas and colleagues have discovered that T cells can be reprogrammed to fight aging, so to speak. Given the right set of genetic...

The post The fountain of youth is … a T cell? appeared first on ��ϳԹ��Դ.

Holy immunity! Bat genes key against COVID, cancer

Nick Wurm — Mon, 16 Oct 2023 11:30:39 +0000

Artibeus jamaicensis, the Jamaican fruit bat (seen here), and Pteronotus mesoamericanus, the Mesoamerican mustached bat." data-description="" />Bats have acquired remarkable traits throughout their evolution. They’re the only mammals that can fly, and they live much longer than other animals their size. But perhaps most impressive is their robust immune system. It protects bats from viruses that wreak havoc in humans, like COVID-19 or Ebola. It also keeps bats relatively cancer-free. How?...

The post Holy immunity! Bat genes key against COVID, cancer appeared first on ��ϳԹ��Դ.

These worms have rhythm

Nick Wurm — Tue, 05 Sep 2023 11:30:18 +0000

C. elegans worm, seen here, Professor Christopher Hammell’s team at the CSHL Cancer Center expanded upon an imaging technique originally developed for use in single cells. This allowed them to witness, for the first time, active gene expression taking place inside an animal." data-description="" />There’s a rhythm to developing life. Growing from a tiny cell cluster into an adult organism takes precise timing and control. The right genes must turn on at the right time, for the right duration, and in the correct order. Losing the rhythm can lead to diseases like cancer. So, what keeps every gene on...

The post These worms have rhythm appeared first on ��ϳԹ��Դ.

Once rhabdomyosarcoma, now muscle

Luis Sandoval — Mon, 28 Aug 2023 19:00:00 +0000

“Every successful medicine has its origin story. And research like this is the soil from which new drugs are born,” says ��ϳԹ��Դ Professor Christopher Vakoc. For six years, Vakoc’s lab has been on a mission to transform sarcoma cells into regularly functioning tissue cells. Sarcomas are cancers that form in connective tissues...

The post Once rhabdomyosarcoma, now muscle appeared first on ��ϳԹ��Դ.

How plants pass down genetic memories

Jennifer Michalowski — Mon, 28 Aug 2023 15:00:16 +0000

Arabidopsis thaliana is a plant species widely used to make fundamental biological discoveries. With the help of this versatile test subject, CSHL scientists have now dug up the secrets of a process that helps control inheritance." data-description="" />When organisms pass their genes on to future generations, they include more than the code spelled out in DNA. Some also pass along chemical markers that instruct cells how to use that code. The passage of these markers to future generations is known as epigenetic inheritance. It’s particularly common in plants. So, significant findings here...

The post How plants pass down genetic memories appeared first on ��ϳԹ��Դ.

Siblings with autism share more of dad’s genome, not mom’s

Luis Sandoval — Mon, 22 May 2023 11:30:51 +0000

��ϳԹ��Դ (CSHL) researchers have flipped the script on autism spectrum disorder (ASD) genetics. Scientists long thought that siblings born with ASD share more of their mother’s genome than their father’s. But CSHL Associate Professor Ivan Iossifov and Professor Michael Wigler have now shown that, in many cases, it’s dad who might be...

The post Siblings with autism share more of dad’s genome, not mom’s appeared first on ��ϳԹ��Դ.

From tragedy, a potential pediatric cancer treatment

Nick Wurm — Wed, 12 Apr 2023 18:00:35 +0000

Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brain cancer that often kills within a year of diagnosis. Surgery is almost impossible because of the tumors’ location. Chemotherapy has debilitating side effects. New treatment options are desperately needed. ��ϳԹ��Դ Professor Adrian Krainer is best known for his groundbreaking research on antisense...

The post From tragedy, a potential pediatric cancer treatment appeared first on ��ϳԹ��Դ.

Identifying cancer genes’ multiple personalities

Margaret Osborne — Mon, 10 Apr 2023 11:30:01 +0000

Mutations in our genes can lead to severe problems, like colon or liver cancer. But cancer is very complex. Mutations in the same genes can lead to different subtypes of tumors in different people. Currently, scientists don’t have a good way to produce such tumor subtypes for study in the lab. Now, Cold Spring Harbor...

The post Identifying cancer genes’ multiple personalities appeared first on ��ϳԹ��Դ.

New shape-shifting antibiotics could fight deadly infections

Margaret Osborne — Tue, 04 Apr 2023 11:30:40 +0000

Staphylococcus aureus (MRSA). MRSA is a superbug resistant to several kinds of antibiotics. According to one estimate, it killed more than 100,000 people worldwide in 2019. Image: © Kateryna_Kon – stock.adobe.com" data-description="" />In the United States alone, drug-resistant bacteria and fungi infect almost 3 million people per year and kill about 35,000. Antibiotics are essential and effective, but in recent years overuse has led to some bacteria developing resistance to them. The infections are so difficult to treat, the World Health Organization deemed antibiotic resistance a top...

The post New shape-shifting antibiotics could fight deadly infections appeared first on ��ϳԹ��Դ.

A molecular machine’s secret weapon exposed

Luis Sandoval — Thu, 23 Feb 2023 16:00:39 +0000

RNAs are having a moment. The foundation of COVID-19 vaccines, they’ve made their way from biochemistry textbooks into popular magazines and everyday discussions. Entire companies have launched dedicated to RNA research. These tiny molecules are traditionally known for helping cells make proteins, but they can do much more. They come in many shapes and sizes,...

The post A molecular machine’s secret weapon exposed appeared first on ��ϳԹ��Դ.

The science of supermoms

Nick Wurm — Tue, 10 Jan 2023 12:30:07 +0000

When you pick up a baby, you can’t help feeling happy. But where does this feeling come from? How does it influence future behavior? ��ϳԹ��Դ (CSHL) Associate Professor Stephen Shea has found that, when it comes to maternal care, social contact is its own reward. “We know that, as human beings, it’s...

The post The science of supermoms appeared first on ��ϳԹ��Դ.

research highlights Archives | ���ϳԹ���Դ