Pavel Osten Archives | ��ϳԹ��Դ

The prostate cancer cell that got away

Luis Sandoval — Tue, 16 Nov 2021 16:00:34 +0000

��ϳԹ��Դ (CSHL) Associate Professor Pavel Osten and Professor Lloyd Trotman have developed a new way to study the life history of prostate cancer in mice. The pair combined their expertise in whole-organ imaging and prostate cancer to track how prostate cancer cells grow into tumors and spread to other organs. Their method...

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Building on 150 years of neuroanatomy

Jasmine Lee — Thu, 07 Oct 2021 14:30:38 +0000

Learn about some of the milestones in neuroanatomy history with our interactive timeline, and read more about CSHL contributions in recent years. In 1873, an Italian biologist named Camillo Golgi stained nerve cells at high resolution. He thought neurons formed a branched and cohesive network and were not individual cells. Fifteen years later, Santiago Ramón...

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Think a census of humans is hard? Try counting their brain cells!

Jasmine Lee — Wed, 06 Oct 2021 15:00:02 +0000

Read about CSHL’s contributions to neuroanatomy in recent years, and learn more about related milestones in our interactive timeline. How does the human brain work? For the last 150 years, researchers have tried to assess its function from its structure, but the answer is still elusive. On October 7, 2021, scientists reached a major milestone,...

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qBrain: Mapping out brain similarities and differences

Jasmine Lee — Fri, 20 Aug 2021 12:00:47 +0000

��ϳԹ��Դ (CSHL) Associate Professor Pavel Osten and his lab map brain connections and catalog different cell types throughout the brain in a quantitative brain-wide (qBrain) catalog. qBrain combines several techniques developed by CSHL and other scientists to label, preserve, image, visualize, count automatically, and trace cells. With these methods, the researchers can...

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NIH BRAIN Initiative invests $9.7 million in CSHL scientists

Luis Sandoval — Tue, 29 Dec 2020 13:30:45 +0000

The National Institute of Health (NIH) Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative awarded a total of $9.7 million in new grants to ��ϳԹ��Դ (CSHL) professors, a senior fellow, and a visiting scientist. Started in 2013, the BRAIN Initiative funds innovative neuroscience projects. The goal is to better treat, prevent, and...

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One experiment: Observing cancer’s progress in a mouse prostate

Brian Stallard — Thu, 14 Mar 2019 20:16:40 +0000

Experts have long known that tumors arise from the migration of cancer cells across organs. But observing the progression of those cancer cells in high resolution, and in turn being able to more effectively hinder their advances, has been a challenge for scientists. Now, a cutting-edge technique originally developed by Associate Professor Pavel Osten’s lab...

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Portrait of a Neuroscience Powerhouse

Peter Tarr — Fri, 27 Apr 2018 16:07:30 +0000

At noon every Tuesday from September through June, scenes from a revolution in neuroscience are playing out at ��ϳԹ��Դ. Week after week, over 100 scientists cram themselves into a ground-floor meeting room in the Beckman Laboratory. It’s standing-room only as everyone in the Neuroscience Program settles in to hear details of the...

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One experiment: A beautiful brain, neuron by neuron

Peter Tarr — Wed, 22 Nov 2017 21:04:59 +0000

What you see here is not a pointillist masterpiece. It is a rendering of the mouse brain, from above, formed by millions of colored dots. Like the famous canvases painted by post-Impressionist Georges Seurat, the triumph of this image is in the relation of the dots themselves. Each colored dot is an inhibitory neuron, and...

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New leadership roles in BRAIN Initiative and International Brain Lab reflect CSHL’s excellence in neuroscience

Peter Tarr — Tue, 24 Oct 2017 16:30:33 +0000

Cold Spring Harbor, NY — The National Institute of Mental Health (NIMH) yesterday announced multiple grant awards totaling $50 million per year for five years to fund cutting-edge research on the brain. The project, part of the BRAIN Initiative Cell Census Network (BICCN) of the National Institutes of Health (NIH), establishes a Center and a...

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First cell-type census of mouse brains: surprises about structure, male-female differences

Peter Tarr — Thu, 05 Oct 2017 12:00:30 +0000

A multiyear project in the Brain Initiative, qBrain is already revealing the brain as never before Cold Spring Harbor, NY — Neuroscientists at ��ϳԹ��Դ (CSHL) have mobilized advanced imaging and computational methods to comprehensively map—“count”—the total populations of specific types of cells throughout the mouse brain. In a study published today in...

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Mapping social behavior-induced brain activation at cellular resolution in the mouse

Public Affairs Administrator — Mon, 05 Jan 2015 19:39:03 +0000

Osten has adapted an automated method he previously developed called serial two-photon (STP) tomography, to scan the full mouse brain in 280 segments. In the current research, a series of behavioral experiments were run featuring a line of mice whose brain cells express a marker called green fluorescent protein (GFP) that glows whenever the c-fos...

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Imaging method linking brainwide cell activation & behavior shows what it means for mice to have sex in mind

Peter Tarr — Mon, 05 Jan 2015 12:48:24 +0000

Automated method detects activity of neurons during specific behaviors, brain-wide, at cellular resolution Cold Spring Harbor, NY — Most people have seen fMRI scans of the human brain. These use a technology called functional magnetic resonance imaging to identify portions of the brain that are active while a subject is being scanned. Fuzzy, ill-defined areas...

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4 CSHL scientists will contribute to President’s BRAIN Initiative under new NIH grants

Peter Tarr — Tue, 30 Sep 2014 10:39:41 +0000

Cold Spring Harbor, NY — Four scientists at ��ϳԹ��Դ (CSHL) will perform research in President Obama’s BRAIN Initiative under two new CSHL grants announced in Washington today. The CSHL grants are among more than 100 issued by the National Institutes of Health (NIH), totaling $46 million for the 2014-15 fiscal year. They...

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CSHL team introduces automated imaging to greatly speed whole-brain mapping efforts

Communications Department — Thu, 12 Jan 2012 22:06:11 +0000

Cold Spring Harbor, NY — A new technology developed by neuroscientists at ��ϳԹ��Դ (CSHL) transforms the way highly detailed anatomical images can be made of whole brains. Until now, means of obtaining such images—used in cutting-edge projects to map the mammalian brain—have been painstakingly slow and available only to a handful of...

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Pavel Osten Archives | ���ϳԹ���Դ