pancreatic cancer Archives | ��ϳԹ��Դ

Let’s get on pancreatic cancer’s nerves

Margaret Osborne — Mon, 09 Feb 2026 13:54:57 +0000

Pancreatic cancer has a lot of nerve. Notoriously tricky to detect, the disease also often resists traditional therapy. So, researchers are urgently looking for new ways to disrupt tumor formation. Though scientists know that the nervous system can help cancer spread, its role in the disease’s earliest stages remains unclear. “One phenomenon that is known...

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Short-circuiting pancreatic cancer

Nick Wurm — Thu, 08 Jan 2026 16:00:45 +0000

Pancreatic ductal adenocarcinoma (PDAC) is the most lethal form of pancreas cancer. It’s also the most common form of the disease. Potential treatments typically target a key mutated oncogene called KRAS. In some cases, PDAC tumors with these mutations have resisted therapeutic efforts. However, combination therapies involving alternative drug targets may one day help clinicians...

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Shapeshifting cancers’ masters, unmasked

Jen A. Miller — Mon, 24 Nov 2025 12:30:01 +0000

Some tumors are almost impossible to treat. That’s especially true for carcinomas, which don’t behave like other malignancies. Some of these tumors act as shapeshifters and start to resemble cells from other organs of the human body, such as skin. This bizarre behavior presents a challenge for existing therapies. “The tumors are notoriously plastic in...

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NCI grants support ‘natural’ cancer research

Margaret Osborne — Mon, 11 Aug 2025 11:30:42 +0000

Complex chemical and biological processes are fundamental for all life on Earth and all the organs inside us. When something goes wrong with these processes, diseases like cancer can arise. At the ��ϳԹ��Դ (CSHL) Cancer Center, Professor John Moses and colleagues use click chemistry, a fast and reliable technique for linking molecules,...

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At the Lab: Catch me if you cancer

Communications Department — Tue, 03 Jun 2025 11:30:16 +0000

Earlier this year, one ��ϳԹ��Դ discovery ended up on FOX TV and the cover of Newsday. Now, hear more about the knowledge gaps that make this discovery so crucial and the noble goals that fuel this work in the first place.

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In pancreatic cancer, a race against time

Samuel Diamond — Wed, 02 Apr 2025 04:05:05 +0000

Cancer Research and conducted with generous support from the Lustgarten Foundation, shows that inhibiting the FGFR2 and EGFR proteins in pancreatic cells can delay or even prevent tumor formation." data-description="" />AI generated voice with David Tuveson’s actual voice Pancreatic cancer is projected to become the second-deadliest cancer by 2030. By the time it’s diagnosed, it’s often difficult to treat. So, for both individual patients and the general population, fighting pancreatic cancer can feel like a race against time. ��ϳԹ��Դ (CSHL) Professor and...

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Cocktails & Chromosomes: Cancer’s identity crisis

Communications Department — Thu, 19 Dec 2024 12:30:14 +0000

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Flipping cancer’s off switch

Communications Department — Thu, 07 Nov 2024 12:30:54 +0000

If there’s one thing cancer knows, it’s growth. Over the last two decades, scientists have observed that many cancers progress by activating a set of proteins called YAP and TAZ, which control cell growth and organ size. When left uncontrolled, YAP/TAZ can lead to tumor formation. So, if you’re looking for new drug targets, why...

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At the Lab Season 1 Research Rewind: Cancer

Communications Department — Tue, 08 Oct 2024 11:30:26 +0000

Miss an episode or two from the first season of our new podcast? Over the next few weeks, we’ll revisit each in a series we call ‘Research Rewind.’ This week At the Lab, you’ll hear all about our cutting-edge cancer research from CSHL scientists Semir Beyaz, Mikala Egeblad, Alea Mills, John Moses, and Christopher Vakoc....

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Old chemo drug, new pancreatic cancer therapy?

Nick Wurm — Mon, 26 Aug 2024 11:30:57 +0000

The fight against cancer is an arms race, and one of the most effective weapons in clinicians’ arsenals is immunotherapy. Immune checkpoint therapy has become the standard for treating several types of cancer. However, the Nobel Prize-winning strategy is ineffective for most pancreatic ductal adenocarcinoma (PDAC) patients. “Immune checkpoint therapy is only an option in...

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How to stop cancer cachexia? Start at the top

Nick Wurm — Mon, 08 Jul 2024 11:30:11 +0000

Cancer is insidious. Throughout tumor progression, the disease hijacks otherwise healthy biological processes—like the body’s immune response—to grow and spread. When tumors elevate levels of an immune system molecule called Interleukin-6 (IL-6), it can cause severe brain dysfunction. In about 50%-80% of cancer patients, this leads to a lethal wasting disease called cachexia. “It’s a...

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At the Lab Episode 13: A more sustainable chemistry

Communications Department — Tue, 02 Jul 2024 11:30:33 +0000

Some of the world’s most precious chemicals are biological in nature. But what can we do when nature offers only a limited supply? This week’s podcast starts on the other side of the globe and ends up back here At the Lab with CSHL’s resident click chemist, Professor John Moses.

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Pancreatic cancer’s cellular amnesia

Margaret Osborne — Mon, 17 Jun 2024 09:00:13 +0000

Things aren’t always as they seem. Take pancreatic cancer, for example. In up to one in 10 cases, researchers have documented a peculiar characteristic. Some of the pancreatic cells appear to have lost their identity. It’s as if they forget what they are. Former ��ϳԹ��Դ (CSHL) postdoc Diogo Maia-Silva, now at Massachusetts...

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Tour CSHL’s Foundations for the Future project

Communications Department — Thu, 09 May 2024 16:00:46 +0000

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Governor Hochul announces $15 million for CSHL expansion

Samuel Diamond — Thu, 09 May 2024 11:30:46 +0000

This year, more than 66,000 people in the U.S. will be diagnosed with pancreatic cancer. That includes about 3,600 New Yorkers. Here on Long Island, ��ϳԹ��Դ (CSHL) has already made great progress in the fight against this deadly disease. But with more than 51,000 people expected to die from pancreatic cancer this...

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Tuveson elected to American Academy of Arts & Sciences

Nick Wurm — Wed, 24 Apr 2024 16:00:11 +0000

��ϳԹ��Դ (CSHL) Professor and Cancer Center Director David Tuveson has been elected to the American Academy of Arts and Sciences. He is one of 250 new members elected to the venerable institution in 2024. Tuveson is a pioneer in cancer research. His groundbreaking work with cancer organoids—miniature versions of tumors—led to the...

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Click, click, boom—150 new molecules

Jennifer Michalowski — Thu, 04 Apr 2024 11:30:05 +0000

Chemical Science, the Royal Society of Chemistry’s flagship journal, calls accelerated SuFEx click chemistry “a robust platform for drug discovery.” Image: © alex_aldo - stock.adobe.com" data-description="" />��ϳԹ��Դ (CSHL) chemists have created a new collection of molecular compounds and begun testing them as potential leads in the search for new drugs. Among these molecules, they found several that show promise for development as antibiotics and cancer therapies. Sounds like a eureka moment? Well, sort of. But it’s more a...

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One Experiment: Pancreatic mucus

Nick Wurm — Tue, 26 Mar 2024 11:30:58 +0000

Is this a scene straight out of the latest Star Trek? No, think much more down-to-earth. What we’re seeing here isn’t the Starship Enterprise on fire in the void. It’s a cross-section of precancerous lesions in the pancreas. These mutated cells have a higher risk of turning into cancer than their healthy counterparts. The image...

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Pancreatic cancer lives on mucus

Luis Sandoval — Wed, 28 Feb 2024 12:30:22 +0000

Knowing exactly what’s inside a tumor can maximize our ability to fight cancer. But that knowledge doesn’t come easy. Tumors are clusters of constantly changing cancer cells. Some become common cancer variants. Others morph into deadlier, drug-resistant varieties. No one truly understands what governs this chaotic behavior. Now, ��ϳԹ��Դ (CSHL) Professor David...

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Pancreatic cancer hijacks a brain-building protein

Nick Wurm — Wed, 14 Feb 2024 12:30:53 +0000

Scientists at ��ϳԹ��Դ (CSHL) and the University of California, Davis have reached a new breakthrough in pancreatic cancer research—eight years in the making. It could help slow the disease’s deadly spread. In 2017, as a postdoc in CSHL’s Tuveson lab, Chang-il Hwang and collaborators from the Vakoc lab uncovered a protein essential...

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pancreatic cancer Archives | ���ϳԹ���Դ