organoids Archives | ��ϳԹ��Դ

CSHL develops endometrial cancer organoid platform

Nick Wurm — Thu, 26 Mar 2026 13:00:21 +0000

More than 68,000 women will be diagnosed with endometrial cancer in 2026. More than 14,000 will die from this condition. While some forms of the disease are treatable, high grade endometrial cancer often resists available immunotherapies. “High grade endometrial cancers (HGEC) are very aggressive,” explains ��ϳԹ��Դ Associate Professor Semir Beyaz. “Even when...

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Our Daughters Foundation donates $200,000 to CSHL

Gina Dipietro — Mon, 23 Mar 2026 11:30:29 +0000

This Endometriosis Awareness Month, there is much to be hopeful for at ��ϳԹ��Դ (CSHL). CSHL Associate Professor Semir Beyaz’s lab, in collaboration with Northwell Health, has published results from the world’s first endometrial biobank. This new platform for discovery was made possible through patient volunteers who donated tissue for fundamental biology research...

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Special edition: Breast Cancer Awareness Month

Communications Department — Thu, 23 Oct 2025 11:30:49 +0000

Today, the five-year survival rate for early-stage breast cancer is about 99%. Awareness drives detection. But what about those breast cancers that aren’t caught early? What about those that evade common therapies? For Breast Cancer Awareness Month, we sat down with CSHL Professor David Spector to discuss some of his lab’s latest research and the...

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NCI grants support ‘natural’ cancer research

Margaret Osborne — Mon, 11 Aug 2025 11:30:42 +0000

Complex chemical and biological processes are fundamental for all life on Earth and all the organs inside us. When something goes wrong with these processes, diseases like cancer can arise. At the ��ϳԹ��Դ (CSHL) Cancer Center, Professor John Moses and colleagues use click chemistry, a fast and reliable technique for linking molecules,...

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A new “link” to triple-negative breast cancer

Margaret Osborne — Mon, 30 Jun 2025 14:00:38 +0000

LINC01235 is seen in red." data-description="" />Breast cancer is one of the most common cancers among women in the United States. Thanks to decades of fundamental research, it’s also one of the most curable. The exception is a particularly aggressive variant known as triple-negative breast cancer (TNBC). It accounts for 10 to 15 percent of all breast cancer cases. It disproportionately...

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In pancreatic cancer, a race against time

Samuel Diamond — Wed, 02 Apr 2025 04:05:05 +0000

Cancer Research and conducted with generous support from the Lustgarten Foundation, shows that inhibiting the FGFR2 and EGFR proteins in pancreatic cells can delay or even prevent tumor formation." data-description="" />AI generated voice with David Tuveson’s actual voice Pancreatic cancer is projected to become the second-deadliest cancer by 2030. By the time it’s diagnosed, it’s often difficult to treat. So, for both individual patients and the general population, fighting pancreatic cancer can feel like a race against time. ��ϳԹ��Դ (CSHL) Professor and...

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Tuveson elected to American Academy of Arts & Sciences

Nick Wurm — Wed, 24 Apr 2024 16:00:11 +0000

��ϳԹ��Դ (CSHL) Professor and Cancer Center Director David Tuveson has been elected to the American Academy of Arts and Sciences. He is one of 250 new members elected to the venerable institution in 2024. Tuveson is a pioneer in cancer research. His groundbreaking work with cancer organoids—miniature versions of tumors—led to the...

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Pancreatic cancer hijacks a brain-building protein

Nick Wurm — Wed, 14 Feb 2024 12:30:53 +0000

Scientists at ��ϳԹ��Դ (CSHL) and the University of California, Davis have reached a new breakthrough in pancreatic cancer research—eight years in the making. It could help slow the disease’s deadly spread. In 2017, as a postdoc in CSHL’s Tuveson lab, Chang-il Hwang and collaborators from the Vakoc lab uncovered a protein essential...

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Growing human organs in the lab

Communications Department — Thu, 03 Aug 2023 11:30:11 +0000

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President’s essay: Bringing bold visions to life

Communications Department — Fri, 26 May 2023 11:30:08 +0000

The art of high-impact research, which is at the core of ��ϳԹ��Դ (CSHL), is to pursue important questions, follow unanticipated leads, and be bold in crafting new ideas. In this way, we challenge our researchers to move science into new frontiers. While our scientists have freedom to pursue their ideas, they are...

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David Tuveson elected to National Academy of Medicine

Nick Wurm — Mon, 17 Oct 2022 15:00:19 +0000

��ϳԹ��Դ (CSHL) Professor and Cancer Center Director David Tuveson was elected to the National Academy of Medicine (NAM) on October 17, 2022. He was recognized for his leadership in pancreatic cancer research. Tuveson’s pioneering work with cancer organoids—miniature versions of tumors—led to the development of the first mouse models for two types...

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How organoids can guide pancreatic cancer therapy

Jennifer Michalowski — Wed, 20 Jul 2022 20:30:34 +0000

��ϳԹ��Դ (CSHL) is at the forefront of using organoid technology to study and treat cancer. Organoids are tiny 3D clusters of cells that are miniature versions of patients’ tumors. Now, CSHL Cancer Center Director David Tuveson and Matthew Weiss, a physician at Northwell Health, have found that pancreatic tumor organoids may help...

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Can cancer be treated by changing its cells?

Communications Department — Mon, 11 Apr 2022 11:30:50 +0000

In 2017, Karen Kostroff, a renowned oncology surgeon at Northwell Health in the New York Metropolitan area, added a new talking point to her standard conversation with breast cancer patients facing tumor removal surgery. These conversations are never easy, because a cancer diagnosis is devastating news. But the new topic seemed to give her patients...

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Paving a path to triple-negative breast cancer treatment

Daniel Dunaief — Tue, 29 Mar 2022 12:00:24 +0000

It’s the cancer version of “mini me.” ��ϳԹ��Դ (CSHL) Professor David Spector, among others, has developed organoids, which are miniature, three-dimensional copies of cancers. Organoids can be derived from cancer or healthy cells. They allow scientists to study the basic biology of particular types of tumors, then to test specific drugs on...

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CSHL organoid facility: Cancer custodians

Communications Department — Fri, 02 Jul 2021 13:00:16 +0000

Part of Dennis Plenker’s daily job, as a ��ϳԹ��Դ (CSHL) research investigator, is growing cancer. And a variety of different ones, too. Depending on the day and the project, different tumors may flourish. They might be aggressive breast cancers. They might be glioblastomas, one of the deadliest brain tumors that rob patients...

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1,100 CSHL heroes

Communications Department — Wed, 06 Jan 2021 18:00:57 +0000

��ϳԹ��Դ (CSHL) celebrated its 130-year anniversary in 2020. Throughout our rich history, the Laboratory has consistently demonstrated the value of its research and education programs to society. CSHL’s efforts in response to the COVID-19 pandemic have been significant. Research in our laboratories as well as initiatives to accelerate the exchange of scientific...

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CSHL’s new organoid facility

Dagnia Zeidlickis — Thu, 05 Nov 2020 17:00:05 +0000

Organoid technology has advanced cancer research and is leading to the development of more effective treatments. Organoids are three-dimensional, live tissue models grown from patient tumors. The fact that organoids are alive makes them powerful as tools to understand a tumor’s response to a specific treatment. If a treatment is effective in the organoid model,...

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One experiment: Organoids as living laboratories

Luis Sandoval — Fri, 30 Oct 2020 18:45:43 +0000

Organoids are tiny balls of cells that look and behave like the organs or tumors from which they were taken. ��ϳԹ��Դ (CSHL) Cancer Center Director David Tuveson pioneered their use in pancreatic cancer research. Scientists use organoids to study how cancers grow, develop, metastasize, and can be detected and treated. At the...

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Live @ the Lab with David Tuveson: Studying pancreatic cancer

Marc Persad — Wed, 29 Jul 2020 15:28:27 +0000

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The first mouse model of human pancreas cancer subtypes

Jennifer Michalowski — Thu, 23 Jul 2020 14:00:39 +0000

K-Ras (in red), a notorious driver of many cancers. Cells that express more K-ras behave more dangerously, dividing more frequently and invading surrounding tissues. Note the dense mats of blue stained cell nuclei, indicating that the cells are dividing quickly. Green stains F-actin, which shows the shapes of cells. Credit: Miyabayashi/Tuveson lab." data-description="" />Scientists at ��ϳԹ��Դ (CSHL) have created the first mouse model of pancreatic cancer that recreates two subtypes of the human disease. The model, published July 23, 2020 in Cancer Discovery, will help researchers investigate why some pancreatic cancers are more aggressive than others and what causes them to progress, paving the way...

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organoids Archives | ���ϳԹ���Դ