one experiment Archives | ��ϳԹ��Դ

One Experiment: The brain’s landscapers

Nick Wurm — Thu, 10 Oct 2024 11:30:04 +0000

Imagine yourself sometime in the far future aboard a routine rocket to Mars. Someone just spilled their drink. Without gravity, it collects in floating blobs that ripple right before your eyes. Now freeze. What you see might look something like the above image from ��ϳԹ��Դ’s (CSHL’s) Cheadle lab. But those purple and...

The post One Experiment: The brain’s landscapers appeared first on ��ϳԹ��Դ.

One Experiment: Brain-body’s feathery display

Nick Wurm — Mon, 15 Jul 2024 11:30:54 +0000

Peacocks symbolize a variety of things—beauty, luck, royalty, and more. But beneath those tall, colorful feathers lurks a hidden aggression. At a glance, the above image may bear some resemblance to peacock plumage. But it’s actually human breast cells (yellow) mingling with mouse neurons. It comes courtesy of ��ϳԹ��Դ (CSHL) Assistant Professor...

The post One Experiment: Brain-body’s feathery display appeared first on ��ϳԹ��Դ.

One Experiment: Pancreatic mucus

Nick Wurm — Tue, 26 Mar 2024 11:30:58 +0000

Is this a scene straight out of the latest Star Trek? No, think much more down-to-earth. What we’re seeing here isn’t the Starship Enterprise on fire in the void. It’s a cross-section of precancerous lesions in the pancreas. These mutated cells have a higher risk of turning into cancer than their healthy counterparts. The image...

The post One Experiment: Pancreatic mucus appeared first on ��ϳԹ��Դ.

One Experiment: The brain’s power lines

Nick Wurm — Mon, 22 Jan 2024 12:30:55 +0000

No, that’s not a bird’s-eye view of the Earth at night. Those glowing green lines connecting each dot aren’t highways. And the big dots aren’t cities or towns either. But there are power lines and, in a way, it is still a map. What you’re looking at is a close-up view of neural circuits deep...

The post One Experiment: The brain’s power lines appeared first on ��ϳԹ��Դ.

One experiment: Organoids as living laboratories

Luis Sandoval — Fri, 30 Oct 2020 18:45:43 +0000

Organoids are tiny balls of cells that look and behave like the organs or tumors from which they were taken. ��ϳԹ��Դ (CSHL) Cancer Center Director David Tuveson pioneered their use in pancreatic cancer research. Scientists use organoids to study how cancers grow, develop, metastasize, and can be detected and treated. At the...

The post One experiment: Organoids as living laboratories appeared first on ��ϳԹ��Դ.

One experiment: DNA barcoding

Jennifer Michalowski — Tue, 14 Apr 2020 16:00:27 +0000

Apocorophium lacustre specimen pictured above was collected, sequenced, and identified by DNA Learning Center students Irene Kowalski and Leah Kesten. Its 250 base pair sequence or colorful “bar code” is superimposed under the specimen's photo. Shrimp photo: Ryan Lauter" data-description="image of shrimp with barcoding in background" />Cold Spring Harbor is teeming with life. Detailed inventories of the organisms that live here began in the late 1800s, with naturalists who carefully classified the flora and fauna. Today, scientists are using sophisticated DNA analyses to survey the plants, animals, and microbes in local habitats—including the shrimp-like creature pictured above, which was collected by...

The post One experiment: DNA barcoding appeared first on ��ϳԹ��Դ.

One experiment: The shape of norovirus

Charlotte Hu — Fri, 25 Oct 2019 20:51:36 +0000

Viruses encapsulate their genetic cargo in a shell of proteins. These shells can form in various shapes and sizes. The shapes of the virus shells are important for developing vaccines against future viral infections. They provide target outlines of the virus for the immune system, which then creates a type of protein called antibodies that...

The post One experiment: The shape of norovirus appeared first on ��ϳԹ��Դ.

One experiment: Observing cancer’s progress in a mouse prostate

Brian Stallard — Thu, 14 Mar 2019 20:16:40 +0000

Experts have long known that tumors arise from the migration of cancer cells across organs. But observing the progression of those cancer cells in high resolution, and in turn being able to more effectively hinder their advances, has been a challenge for scientists. Now, a cutting-edge technique originally developed by Associate Professor Pavel Osten’s lab...

The post One experiment: Observing cancer’s progress in a mouse prostate appeared first on ��ϳԹ��Դ.

One experiment: Building a brain

Peter Tarr — Thu, 16 Aug 2018 15:14:21 +0000

We think of ourselves as unique individuals, yet developmental biology reveals what all of us must have in common before our experiences even begin to differentiate us. ��ϳԹ��Դ Professor Josh Huang and his team show in these images how a program that has evolved over eons and is imprinted in genes unfurls...

The post One experiment: Building a brain appeared first on ��ϳԹ��Դ.

One experiment: Twice the tomatoes

Andrea Alfano — Thu, 22 Mar 2018 18:22:44 +0000

Those plump red fruits aren’t the only sweets spots of a tomato plant. The branches have them too. When breeding plants to produce more fruit, “you want to be in a sweet spot” in terms of branching because “plants have to be balanced in their growth,” says Professor Zachary Lippman. That two-pronged plant on the...

The post One experiment: Twice the tomatoes appeared first on ��ϳԹ��Դ.

One experiment: When cancer is hiding in plain sight

Peter Tarr — Thu, 01 Mar 2018 15:28:20 +0000

Everyone knows how important the immune system is—our lives utterly depend upon it. Its role in fighting bacteria and common viruses is something we take for granted. Few people know that its protection extends to viruses that can cause cancer. And yet cancer is so common. When it strikes, is the immune system letting us...

The post One experiment: When cancer is hiding in plain sight appeared first on ��ϳԹ��Դ.

One experiment: A beautiful brain, neuron by neuron

Peter Tarr — Wed, 22 Nov 2017 21:04:59 +0000

What you see here is not a pointillist masterpiece. It is a rendering of the mouse brain, from above, formed by millions of colored dots. Like the famous canvases painted by post-Impressionist Georges Seurat, the triumph of this image is in the relation of the dots themselves. Each colored dot is an inhibitory neuron, and...

The post One experiment: A beautiful brain, neuron by neuron appeared first on ��ϳԹ��Դ.

One experiment: Bacteria-trapping DNA webs are repurposed by cancer cells

Peter Tarr — Thu, 19 Oct 2017 19:50:43 +0000

Cancer is infamous for repurposing molecules and mechanisms our body routinely uses to sustain itself. This remarkable 3D image, made by CSHL’s expert electron microscopist Stephen Hearn, dramatically captures one such mechanism, spiderweb-like structures made of DNA and studded with toxic enzymes. Normally, these webs are cast out into extracellular space by white blood cells...

The post One experiment: Bacteria-trapping DNA webs are repurposed by cancer cells appeared first on ��ϳԹ��Դ.

One experiment: A drug for SMA visibly repairs defective cells

Peter Tarr — Thu, 01 Dec 2016 18:38:50 +0000

Think of this pair of images as the scientific equivalent of an exclamation point. Here is proof positive of an idea first advanced in 2003 by CSHL Professor Adrian Krainer and colleagues. In a paper entitled “Correction of disease-associated exon skipping,” they suggested a way to make a drug to treat spinal muscular atrophy. A...

The post One experiment: A drug for SMA visibly repairs defective cells appeared first on ��ϳԹ��Դ.

One experiment: How the breast “remembers” a first pregnancy

Peter Tarr — Sat, 02 Jul 2016 16:46:54 +0000

Women consistently report that nursing is easier after a first pregnancy. Some remarkable genomic work led by Professor Greg Hannon provides a biological reason for this effect and shows more broadly how bodily experiences can prepare us to respond to future stimuli. The razor-thin slice of breast tissue pictured here is sampled from a mouse...

The post One experiment: How the breast “remembers” a first pregnancy appeared first on ��ϳԹ��Դ.

One experiment: Cellular highways carry anti-cancer cargoes

Peter Tarr — Thu, 09 Apr 2015 12:00:40 +0000

Super-resolution microscopy provides the surprising answer We’re swimming deep inside the cytoplasm, the watery interior of a cell, which, at the scale of this image, is living room-sized. The membrane—the oily wall that protects everything inside—is perhaps 20 feet away. The green “threads” crisscrossing around us are microtubules, gossamer-thin cargo roads that project inward from...

The post One experiment: Cellular highways carry anti-cancer cargoes appeared first on ��ϳԹ��Դ.

One experiment: McClintock’s historic discovery

Peter Tarr — Mon, 01 Dec 2014 14:01:59 +0000

One of the first things Milislav Demerec did in 1941, after being appointed Director of the Department of Genetics at Cold Spring Harbor, was to hire a young geneticist named Barbara McClintock. It was an inspired choice. She spent the rest of her long career at the Laboratory and won a Nobel Prize in 1983—for...

The post One experiment: McClintock’s historic discovery appeared first on ��ϳԹ��Դ.

One experiment: Sometimes our cells express only one gene copy. Why?

Peter Tarr — Sun, 01 Jun 2014 20:21:32 +0000

Humans, like most mammals, are made up of diploid cells. In the nucleus of each cell there are two copies of every gene, one inherited from each parent. Here, we see the nuclei (circled in white) of several diploid cells from a mouse: neural cells in an early stage of development. Each nucleus contains one...

The post One experiment: Sometimes our cells express only one gene copy. Why? appeared first on ��ϳԹ��Դ.

One experiment: Capturing a drug in its binding pocket

Peter Tarr — Sat, 01 Jun 2013 20:51:01 +0000

This computer-generated 3-D image, from Erkan Karakas, Ph.D., a postdoctoral researcher in the lab of CSHL Associate Professor Hiro Furukawa, reveals in exquisite detail the shape of a previously elusive binding pocket for a drug that may help treat neurodegenerative diseases including Alzheimer’s and Parkinson’s, as well as brain damage from stroke. The neuroprotective drug...

The post One experiment: Capturing a drug in its binding pocket appeared first on ��ϳԹ��Դ.

One experiment: When anti-cancer drug meets tumor

Peter Tarr — Fri, 05 Apr 2013 12:00:48 +0000

A complex interplay of the drug, cancer cells, the tissue surrounding the tumor, and the immune system Studying cancer in its natural environment—at tumor sites in living animals—provides insights scientists can’t obtain when they look at cancer cells isolated in culture dishes. CSHL’s Mikala Egeblad and her team have been making time-lapse images of mouse...

The post One experiment: When anti-cancer drug meets tumor appeared first on ��ϳԹ��Դ.

one experiment Archives | ���ϳԹ���Դ