obesity Archives | ��ϳԹ��Դ

Researchers find new way to slow memory loss in Alzheimer’s

Gina Dipietro — Thu, 05 Feb 2026 12:30:28 +0000

Alzheimer’s disease is often measured in statistics: millions affected worldwide, cases rising sharply, costs climbing into the trillions. For families, the disease is experienced far more intimately. “It’s a slow bereavement,” says ��ϳԹ��Դ Professor Nicholas Tonks, whose mother lived with Alzheimer’s. “You lose the person piece by piece.” There’s a lot of...

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A recipe to reverse cancer’s sweet tooth

Nick Wurm — Mon, 16 Jun 2025 11:30:58 +0000

Sometimes sugar isn’t so sweet. Sometimes, it’s downright deadly. Glycation occurs when an excess of sugars called reducing sugars attach to important proteins in the body. The process has been linked to diabetes and obesity. It’s usually something to avoid, and the body relies on the FN3K kinase to break glycation down. But cancer flips...

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Cocktails & Chromosomes: How the brain and body communicate

Communications Department — Thu, 19 Sep 2024 11:30:08 +0000

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The science behind Ozempic and Wegovy

Communications Department — Thu, 11 Jul 2024 11:30:12 +0000

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How diet may impact cancer and possible treatments

Margaret Osborne — Thu, 01 Feb 2024 12:30:30 +0000

About 10 million people die every year of cancer. It’s the second leading cause of death in the U.S., behind heart disease, with more than 1,500 fatalities here each day. Yet, much about it remains unknown. Researchers have linked some behaviors to a higher risk of developing the disease. People who smoke, for example, tend...

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Cocktails & Chromosomes: You are what you eat

Communications Department — Thu, 14 Dec 2023 17:00:40 +0000

The question is how! Whet your appetite for discovery with this mouthwatering talk on diet and nutrition from CSHL’s Semir Beyaz.

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Bite into this diet and disease quiz

Communications Department — Wed, 05 Jul 2023 11:30:26 +0000

{“questions”:{“fmpo8”:{“id”:”fmpo8″,”mediaType”:”image”,”answerType”:”text”,”imageCredit”:””,”image”:”https:\/\/www.cshl.edu\/wp-content\/uploads\/2021\/09\/normal-mouse-small-intestine.jpg”,”imageId”:”56101″,”video”:””,”imagePlaceholder”:””,”imagePlaceholderId”:””,”title”:”Which one of these diets makes it harder for the immune system to recognize and attack colorectal cancer in mice?”,”desc”:”CSHL Assistant Professor Semir Beyaz has found that a high-fat diet masks intestinal cancer in mice by suppressing a cell tag called MHC-II. When these tags were reduced in mice, their immune systems didn\u2019t recognize potentially...

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Humans of Banbury: Interview with Marcus Goncalves

Jenna Jacobs — Wed, 31 May 2023 15:24:02 +0000

In March 2023, the Banbury Center welcomed experts for “The Future of Investigational Medicine: Utilizing Science to Optimize the Early Phase Oncology Clinical Trial Effort.” During the meeting, I had the opportunity to sit down with Marcus Goncalves, M.D., Ph.D. Dr. Goncalves is an endocrinologist and laboratory scientist at Weill Cornell Medicine. He received his...

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Your diet is your future

Communications Department — Wed, 03 May 2023 11:30:50 +0000

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Got junk food on the brain? These cells may be to blame

Jennifer Michalowski — Thu, 20 Oct 2022 15:00:09 +0000

A region of the brain called the amygdala is responsible for powerful emotions like fear. Now, researchers have found the amygdala may also be to blame for overeating. ��ϳԹ��Դ (CSHL) Professor Bo Li has discovered a group of neurons in the amygdala that drives mice to eat fatty or sugary foods—even when...

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How high-fat diets allow cancer cells to go unnoticed

Luis Sandoval — Tue, 28 Sep 2021 12:00:48 +0000

A high-fat diet increases the incidence of colorectal cancer. ��ϳԹ��Դ Fellow Semir Beyaz and collaborators from Harvard Medical School and Massachusetts Institute of Technology have discovered that in mice, fat disrupts the relationship between intestinal cells and the immune cells that patrol them looking for emerging tumors. Reconfiguring the gut microbiome may...

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Plus-sized fly: a model to understand the mechanisms underlying human obesity

Peter Tarr — Tue, 10 Jan 2017 12:00:06 +0000

Cold Spring Harbor, NY — Why do people become obese? Poor dietary choices and overeating seem like clear causes, but what is at the root of these behaviors? Significantly overweight people may be genetically predisposed to be affected disproportionately when faced with the ready availability of calorie-laden treats. It appears, in others words, that some...

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��ϳԹ��Դ and GSK to develop diabetes and obesity therapeutic

Communications Department — Mon, 23 Mar 2015 06:30:20 +0000

Cold Spring Harbor, NY — ��ϳԹ��Դ (CSHL) today announced a collaboration with GSK to develop a treatment for obesity and type 2 diabetes. Scientists at CSHL and GSK will pursue drug development based on a novel approach to regulate the enzymatic activity of the phosphatase PTP1B. The goal of the multi-year CSHL-GSK...

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Study shows how neurons enable us to know smells we like and dislike, whether to approach or retreat

Peter Tarr — Mon, 07 Oct 2013 17:14:18 +0000

Some basic biology learned from study of fruit flies could help us understand food choice in obese people. Cold Spring Harbor, NY — Think of the smell of freshly baking bread. There is something in that smell, without any other cues—visual or tactile—that steers you toward the bakery. On the flip side, there may be a...

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Powerful antibody-based strategy suggests a new therapeutic approach to diabetes and obesity

Peter Tarr — Thu, 29 Sep 2011 15:19:22 +0000

Cold Spring Harbor, NY — The work of a team of scientists at ��ϳԹ��Դ (CSHL) led by Professor Nicholas Tonks FRS, suggests a way to overcome one of the major technical obstacles preventing a leading therapeutic target for diabetes and obesity from being addressed successfully by novel drugs. The target is an...

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