Michael Wigler Archives | ��ϳԹ��Դ

Empowering Insights: The science behind health

Communications Department — Mon, 18 Nov 2024 12:30:22 +0000

The opportunity to turn curiosity into discoveries that impact the human condition is at the core of ��ϳԹ��Դ’s mission. Our scientists are empowered to ask big questions and search for solutions to biology’s most challenging problems. Doing that requires interdisciplinary study, and the Laboratory’s brain-body physiology program encourages our scientists to confront...

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Autism genetics: The faces behind the data

Margaret Osborne — Thu, 16 May 2024 11:30:35 +0000

More than 5.4 million adults in the U.S. have autism. That’s about the populations of Los Angeles and Phoenix combined. Autism, or autism spectrum disorder (ASD), is a developmental disability that affects how a person experiences the world around them. If this definition sounds broad, there’s a reason for that. Autism manifests in many different...

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From cancer genetics to cancer treatments

Jen A. Miller — Thu, 18 Jan 2024 12:30:49 +0000

What is cancer? How does it develop and spread? And how do we stop it? Thanks to science, today’s doctors can better answer all of these questions. That’s not because of one eureka moment. Instead, it’s the result of thousands of discoveries that built upon each other. Case in point: two of the most important...

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The evolution of autism research

Luis Sandoval — Thu, 25 May 2023 11:30:32 +0000

The scientific community’s views on autism spectrum disorder (ASD) have changed significantly over the last two decades. ��ϳԹ��Դ (CSHL) has played an important role in this evolution, as our scientists have uncovered several genetic factors underlying ASD. Of course, that evolution didn’t happen overnight. It is the result of progressive research that...

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Autism in the family tree

Communications Department — Tue, 23 May 2023 11:30:47 +0000

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Siblings with autism share more of dad’s genome, not mom’s

Luis Sandoval — Mon, 22 May 2023 11:30:51 +0000

��ϳԹ��Դ (CSHL) researchers have flipped the script on autism spectrum disorder (ASD) genetics. Scientists long thought that siblings born with ASD share more of their mother’s genome than their father’s. But CSHL Associate Professor Ivan Iossifov and Professor Michael Wigler have now shown that, in many cases, it’s dad who might be...

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How well do you know autism spectrum disorders?

Nick Fiore — Mon, 24 Apr 2023 11:30:32 +0000

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The genetic landscape of autism

Communications Department — Tue, 16 Aug 2022 12:00:20 +0000

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After 100 years of research, autism remains a puzzle

Communications Department — Thu, 04 Aug 2022 11:30:36 +0000

« Previous Story Next Story » Michael Wigler, a professor at ��ϳԹ��Դ (CSHL) was surprised. A molecular biologist and geneticist, with a background in mathematics and medicine, he devoted two decades of his research career to studying the causes of autism. In the early 2000s, Wigler and his team revealed that a...

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Tuveson and Wigler elected AACR Academy Fellows

Sara Roncero-Menendez — Tue, 12 May 2020 14:25:39 +0000

��ϳԹ��Դ (CSHL) Cancer Center Director David Tuveson and Professor Michael Wigler have been elected as Fellows of the American Association for Cancer Research (AACR) Academy. Tuveson is being honored for his work on developing preclinical and clinical therapeutic strategies for pancreatic cancer, and for characterizing many of the barriers to successful pancreatic...

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Dog adaptations are like brain adaptations

Eliene Augenbraun — Wed, 06 May 2020 15:00:32 +0000

Group Of Various Kind Of Purebred Dogs Photos by Pond5" data-description="Illustration of a couple dozen different breeds of dogs" />Autism can sometimes be inherited, but exactly how is complicated. CSHL Professor Michael Wigler defied the field’s common wisdom in the mid-2000s to figure out some of the genetics underlying autism. It turns out that dogs can help explain Wigler’s approach. In a video call conducted March 20, 2020, Wigler mused about how remarkable it...

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The status of autism research—in verse

Communications Department — Wed, 29 Apr 2020 17:30:22 +0000

Where do we stand in our understanding of autism genetics—and what major questions remain? A molecular biologist, supplies answers in stanzas. 1. where have we gotten to from genetic analysis? a. an understanding of the genetic architecture i. role of de novo mutation ii. role of transmission b. a bevy of target genes c. estimates...

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CSHL investigators rank among world’s most highly cited

Brian Stallard — Wed, 11 Dec 2019 14:00:14 +0000

Seven researchers affiliated with ��ϳԹ��Դ (CSHL) have been named among the scientists producing the top 1 percent of the most highly cited research in the world. They join CSHL Professor Michael Wigler, who is listed as one of the most extensively cited researchers of all time. The annual Highly Cited Researchers list...

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Portrait of a Neuroscience Powerhouse

Peter Tarr — Fri, 27 Apr 2018 16:07:30 +0000

At noon every Tuesday from September through June, scenes from a revolution in neuroscience are playing out at ��ϳԹ��Դ. Week after week, over 100 scientists cram themselves into a ground-floor meeting room in the Beckman Laboratory. It’s standing-room only as everyone in the Neuroscience Program settles in to hear details of the...

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Autism genetics study calls attention to impaired motor skills, general cognitive impairment

Peter Tarr — Wed, 07 Feb 2018 19:14:06 +0000

Cold Spring Harbor, NY — A new study of the genetic factors involved in the causation of autism spectrum disorders (ASD) draws fresh attention to the impact these illnesses have on motor skills, and more broadly on cognitive function. “Diminished motor skills appear to be an almost universal property of children with autism,” says Professor...

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New method to determine before surgery which prostate tumors pose a lethal threat

Peter Tarr — Fri, 01 Dec 2017 16:38:11 +0000

Prostate cancer is common and largely nonlethal. But for some 21,000 men—a small percentage of the total, but a nonetheless substantial number—the disease is fatal. For earlier and more accurate detection, the Krasnitz and Wigler labs have devised a new method to analyze tumor biopsies to identify the most lethal forms of prostate cancer.

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Next-gen cancer test

Peter Tarr — Fri, 24 Nov 2017 17:00:40 +0000

Knowing that cancers become lethal when they spread, investigators at ��ϳԹ��Դ (CSHL) seek a way of detecting tumors much earlier than now possible—when they’re more likely to be curable. Fleshing out an idea Professor Michael Wigler had years ago—before there was technology to act on it—research led by Associate Professor Alexander Krasnitz...

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New statistical method finds shared ancestral gene variants involved in autism’s cause

Peter Tarr — Wed, 21 Jun 2017 12:56:26 +0000

Cold Spring Harbor, NY — The way you measure things has a lot to do with the value of the results you get. If you want to know how much a blueberry weighs, don’t use a bathroom scale; it isn’t sensitive enough to register a meaningful result. While much more is at stake, the same...

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The 2016 ��ϳԹ��Դ Double Helix Medals dinner

Communications Department — Fri, 02 Dec 2016 01:02:49 +0000

The 2016 ��ϳԹ��Դ Double Helix Medal Dinner video that debuted at the 2016 dinner, Dec 1, 2016.

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Why is autism more common in boys?

Andrea Alfano — Fri, 29 Apr 2016 15:48:55 +0000

Boys diagnosed with autism far outnumber their female counterparts. Autism genetics researcher Ivan Iossifov lays out what research into the disorder’s genetic basis reveals about the reasons for this striking pattern. any of the numbers pegged to autism are staggering. By some estimates, as many as 1 in 68 children lies somewhere along the autism...

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Michael Wigler Archives | ���ϳԹ���Դ