Linda Van Aelst Archives | ��ϳԹ��Դ

Veronica Beard hosts CSHL–Penny’s Flight fundraiser

Caroline Cosgrove — Mon, 07 Apr 2025 16:00:45 +0000

Fashion and philanthropy came together to support crucial scientific research, as ��ϳԹ��Դ (CSHL) and the Penny’s Flight Foundation recently partnered with women’s designer clothing brand Veronica Beard for an exclusive in-person shopping event at the brand’s luxury storefront in Manhasset, NY. The event featured a sit-down discussion between CSHL’s Sarah Kitt and...

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CSHL high schoolers named top Regeneron Scholars

Nick Wurm — Mon, 03 Mar 2025 12:30:03 +0000

��ϳԹ��Դ’s (CSHL’s) Ishana Chadha and Keita Takahashi have been named among the top high school scientists in the country. Each year, about 2,500 high school seniors compete in the Regeneron Science Talent Search. These teenagers represent the future of science, technology, engineering, and mathematics. Chadha, a volunteer intern in CSHL’s Van Aelst...

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New hope in the fight against neurofibromatosis

Nick Wurm — Mon, 18 Mar 2024 11:30:31 +0000

It’s the most common single-gene neurological disorder in the world. It is typically diagnosed in children. It’s often accompanied by learning challenges. It can lead to tumors in the brain, spinal cord, and throughout the body. It’s called neurofibromatosis type 1 (NF1). One out of every 3,000 people is born with the disease. And there...

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Chronic stress spreads cancer … here’s how

Margaret Osborne — Thu, 22 Feb 2024 16:00:10 +0000

Stress is inevitable. But too much of it can be terrible for our health. Chronic stress can increase our risk for heart disease and strokes. It may also help cancer spread. How this works has remained a mystery—a challenge for cancer care. Xue-Yan He, a former postdoc in ��ϳԹ��Դ (CSHL) Adjunct Professor...

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President’s essay: Bringing bold visions to life

Communications Department — Fri, 26 May 2023 11:30:08 +0000

The art of high-impact research, which is at the core of ��ϳԹ��Դ (CSHL), is to pursue important questions, follow unanticipated leads, and be bold in crafting new ideas. In this way, we challenge our researchers to move science into new frontiers. While our scientists have freedom to pursue their ideas, they are...

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Communication breakdown in the brain

Communications Department — Tue, 03 Jan 2023 12:30:21 +0000

Seizures come suddenly, triggered by stress, fever, flashing lights, or even just feeling tired. Some cause the body to jerk and shake while others can produce strange sensations, make one lose a sense of awareness, or faint. They can happen when the person is awake or asleep. When they pass, after a few seconds or...

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Uncovering how immune cells nurture brain connections

Communications Department — Mon, 07 Mar 2022 20:00:54 +0000

Microglia, the immune cells of the brain, are known for eating up unwanted items like germs and debris, much as their counterparts do in the rest of the body. In early childhood, certain microglia remove unneeded connections, or synapses, to shape the adult brain’s organized circuitry. Now, ��ϳԹ��Դ (CSHL) Professor Linda Van...

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Reversing a genetic cause of poor stress responses in mice

Jasmine Lee — Wed, 07 Apr 2021 15:00:06 +0000

Ophn1 gene causes mice to respond to stressful situations with an inappropriate helpless behavior. CSHL Professor Linda Van Aelst and her lab wanted to know the exact location in the mouse brain affected by the lack of Ophn1 that leads to this helpless/depressive behavior. In this image of a mouse brain, the green color shows the prelimbic region of the medial prefrontal cortex, where the researchers injected a virus to delete Ophn1. Ophn1 (red) is still present in other parts of the brain. The researchers discovered that deleting the gene in only this part of the brain caused the observed failure in stress adaptation. Human brains are organized similarly, so their findings in mice may be applicable to helping human patients who experience an inability to deal with stressful situations. Image: Minghui Wang/Van Aelst Lab." data-description="" />Everyone faces stress occasionally, whether in school, at work, or during a global pandemic. However, some cannot cope as well as others. In a few cases, the cause is genetic. In humans, mutations in the OPHN1 gene cause a rare X-linked disease that includes poor stress tolerance. ��ϳԹ��Դ (CSHL) Professor Linda Van...

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How chandelier cells light up the brain

Jennifer Michalowski — Thu, 18 Jun 2020 15:00:51 +0000

Within the intricate network of cells that make up the brain, chandelier cells stand out for their elaborate, branching structure. With an elegant shape similar to that of its namesake, a single chandelier cell reaches out to connect and communicate with more than 100 other neurons. Abnormalities in chandelier cells have been linked to epilepsy,...

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Historic building—groundbreaking science

Brian Stallard — Tue, 29 Oct 2019 14:48:10 +0000

��ϳԹ��Դ (CSHL) is unique among cutting-edge research campuses. Along the waterside, you’ll find quaint cottages looking unchanged from their nineteenth-century whaling town origins. Deeper into these grounds, cottages are eclipsed by the red brick facades and sweeping arches that housed some of science’s first forays into genetics in the early 1900s. Deeper...

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Chandelier neuron requires ‘Velcro-like’ molecule to form connections

Brian Stallard — Mon, 04 Mar 2019 16:00:30 +0000

Cold Spring Harbor, NY — As a brain grows, the neurons within it establish themselves, forming lasting connections with their neighbors. They’re creating the vast cell networks that ensure a mind and body run smoothly. Now, researchers have determined how a crucial kind of neuron called a chandelier cell (ChC) forms connections with other neurons,...

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Portrait of a Neuroscience Powerhouse

Peter Tarr — Fri, 27 Apr 2018 16:07:30 +0000

At noon every Tuesday from September through June, scenes from a revolution in neuroscience are playing out at ��ϳԹ��Դ. Week after week, over 100 scientists cram themselves into a ground-floor meeting room in the Beckman Laboratory. It’s standing-room only as everyone in the Neuroscience Program settles in to hear details of the...

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Watch a baby neuron crawl its way along a brain

Public Affairs Administrator — Thu, 02 Nov 2017 20:21:28 +0000

“Adult neurogenesis” is the process in which new neurons replace old. But how do newborn neurons reach the part of the brain they need to rebuild? CSHL researchers have figured out exactly how these “neuroblasts” inch their way across the brain.

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Fantastic journey: how newborn neurons find their proper place in the brain

Peter Tarr — Thu, 02 Nov 2017 12:00:53 +0000

Cold Spring Harbor, NY — One of the most hopeful discoveries of modern neuroscience is firm proof that the human brain is not static following birth. Rather, it is continually renewing itself, via a process called postnatal neurogenesis—literally, the birth of new neurons. It begins not long after birth and continues into old age. There is...

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Neuroscientists explain how mutated X-linked mental retardation protein impairs neuronal function

Peter Tarr — Tue, 24 Jun 2014 06:28:00 +0000

Cold Spring Harbor, NY — There are new clues about malfunctions in brain cells that contribute to intellectual disability and possibly other developmental brain disorders. Professor Linda Van Aelst of ��ϳԹ��Դ (CSHL) has been scrutinizing how the normal version of a protein called OPHN1 helps enable excitatory nerve transmission in the brain,...

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Scientists discover two proteins that control chandelier cell architecture

Communications Department — Thu, 16 Jan 2014 10:00:56 +0000

Chandelier cells, a group of powerful inhibitory neurons, are important in epilepsy and schizophrenia Cold Spring Harbor, NY — Chandelier cells are neurons that use their unique shape to act like master circuit breakers in the brain’s cerebral cortex. These cells have dozens, often hundreds, of branching axonal projections—output channels from the cell body of...

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Christina Renna Foundation raises $20,000 for pediatric cancer research at CSHL

Communications Department — Fri, 25 Jan 2013 00:00:57 +0000

Foundation started by Long Island family raises funds for CSHL at sixth annual Angel’s Wish Gala Cold Spring Harbor, NY — The Christina Renna Foundation raised $20,000 at their sixth annual Angel’s Wish Gala on January 11, 2013. The funds will be used to support cancer research in the laboratory of Dr. Linda Van Aelst...

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Research identifies protein that regulates key ‘fate’ decision in cortical progenitor cells

Communications Department — Thu, 20 Sep 2012 20:49:12 +0000

+ transfected cells across neocortical layers." data-description="" />DOCK7 expression determines if radial glial cells will proliferate or differentiate Cold Spring Harbor, NY — Researchers at ��ϳԹ��Դ (CSHL) have solved an important piece of one of neuroscience’s outstanding puzzles: how progenitor cells in the developing mammalian brain reproduce themselves while also giving birth to neurons that will populate the emerging...

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X-linked mental retardation protein is found to mediate synaptic plasticity in hippocampus

Communications Department — Wed, 19 Oct 2011 15:34:11 +0000

Cold Spring Harbor, NY — Scientists at ��ϳԹ��Դ (CSHL) have solved part of a puzzle concerning the relationship between changes in the strength of synapses—the tiny gaps across which nerve cells in the brain communicate—and dysfunctions in neural circuits that have been linked with drug addiction, mental retardation and other cognitive disorders....

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CSHL researchers unravel how a protein helps nerve cells recycle neurotransmitter-containing vesicles

Peter Tarr — Wed, 03 Jun 2009 15:40:04 +0000

Oligophrenin-1, faulty in mental retardation, plays a vital pre-synaptic role in normal neural signaling Cold Spring Harbor, NY — Brain cells, or neurons, transmit electrical signals efficiently only when they recycle tiny cellular sacs that store signaling chemicals called neurotransmitters. When a neuron is stimulated, the sacs are expelled into the synapse—the tiny junction between...

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Linda Van Aelst Archives | ���ϳԹ���Դ