Joshua Dubnau Archives | ��ϳԹ��Դ

Plus-sized fly: a model to understand the mechanisms underlying human obesity

Peter Tarr — Tue, 10 Jan 2017 12:00:06 +0000

Cold Spring Harbor, NY — Why do people become obese? Poor dietary choices and overeating seem like clear causes, but what is at the root of these behaviors? Significantly overweight people may be genetically predisposed to be affected disproportionately when faced with the ready availability of calorie-laden treats. It appears, in others words, that some...

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Riding out of the shadows of ALS, toward better treatments

Andrea Alfano — Mon, 01 Aug 2016 19:55:36 +0000

Watson School graduate Lisa Krug studied ALS in flies, but the human element of this research always remained present for her. She explains in this guest blog post. LS is a disease that makes itself nearly invisible. Although each year 6,400 Americans are diagnosed with Amyotrophic Lateral Sclerosis, often called ALS or Lou Gehrig’s disease, they...

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Student Lisa Krug quells the transposon storm of ALS

Communications Department — Mon, 22 Feb 2016 21:45:49 +0000

Every 90 minutes, someone in the US is diagnosed with amyotrophic lateral sclerosis—ALS. Most people live only a few years after they show the first signs of the disease, such as muscle cramps, weakness, and difficulty speaking or swallowing. As the disease progresses, patients lose the ability to move many parts of their bodies. They...

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CSHL neuroscientists show ’jumping genes’ may contribute to aging-related brain defects

Communications Department — Sun, 07 Apr 2013 13:00:27 +0000

Transposon abundance and activity in the fruit fly brain increases with age and correlates with neurological degeneration. Cold Spring Harbor, NY — As the body ages, the physical effects are notable; wrinkles in the skin appear, physical exertion becomes harder. But there are also less visible processes going on. Inside aging brains there is another...

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Neuroscience research brief: Can you smell that?

Communications Department — Wed, 27 Mar 2013 08:00:41 +0000

A discovery about how brain circuits engage memory in response to odor Cold Spring Harbor, NY — An organism’s genetic information is stored in its genes, chemical blueprints for the manufacture of proteins. Over a decade ago, however, a new class of genes was identified that do not code for proteins. Instead, they encode small...

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Storm of ‘awakened’ transposons may cause brain-cell pathologies in ALS, other illnesses

Peter Tarr — Tue, 04 Sep 2012 19:50:33 +0000

Cold Spring Harbor, NY — A team of neuroscientists and informatics experts at ��ϳԹ��Դ (CSHL) reports important progress in an effort to understand the relationship between transposons—sequences of DNA that can jump around within the genome, potentially causing great damage—and mechanisms involved in serious neurodegenerative disorders including ALS (amyotrophic lateral sclerosis, also...

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Short- and long-term memories depend on the same gene, acting in different neuronal circuits, CSHL study finds

Peter Tarr — Fri, 14 Aug 2009 15:15:23 +0000

Drosophila." data-description="" />Activity of the rutabaga gene determines much of a fruit fly’s ability to learn and remember Cold Spring Harbor, NY — Why is it that you can instantly recall your own phone number but have to struggle with your mental Rolodex to remember a new number you heard a few moments ago? The two tasks...

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��ϳԹ��Դ scientists identify a mechanism that helps fruit flies lock-in memories

Communications Department — Wed, 28 May 2008 19:33:47 +0000

A protein called Pum regulates the expression of genes that alter synaptic plasticity Cold Spring Harbor, NY — To lock in a memory, nerve cells must strengthen their connections with some neighbors but not others. Three research groups at ��ϳԹ��Դ (CSHL) have collaborated to identify a protein whose action helps alter the...

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Pavlov’s flies: Researchers identify fruit fly memory mutants

Communications Department — Mon, 17 Feb 2003 05:00:00 +0000

Broad implications seen for treating Alzheimer’s and other human diseases By teaching fruit flies to avoid an odor and isolating mutant flies that can’t remember their lessons, researchers at ��ϳԹ��Դ in New York have identified dozens of genes required for long-term memory. In the same study, using DNA chip technology, the scientists...

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Scientists switch memory recall on and off in fruit flies

Communications Department — Wed, 23 May 2001 05:00:00 +0000

Cold Spring Harbor, NY — Scientists at ��ϳԹ��Դ have used a genetic strategy in fruit flies to switch electrical activity in the insect brain on and off at will. In doing so, they have made the surprising discovery that switching off electrical activity in the brain blocks memory recall, but not initial...

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Joshua Dubnau Archives | ���ϳԹ���Դ