Jason Sheltzer Archives | ��ϳԹ��Դ

A full-circle moment in cancer research

Communications Department — Wed, 16 Aug 2023 11:30:45 +0000

High-tech experiments by CSHL Postdoctoral Researcher Asad Lakhani and colleagues allow us to see early 20th-century hypotheses in a whole new light.

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Genome hack reignites century-old cancer debate

Luis Sandoval — Mon, 14 Aug 2023 11:30:10 +0000

What causes cancer? Science and medicine have been trying to answer this question for centuries. In the late 1800s, scientists observed that most tumors have an odd number of chromosomes. They thought this imbalance, called aneuploidy, may be a driving force in cancer development. Since then, technological advancements—and limitations—have pushed science in other directions. But...

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Calculating the path of cancer

Jennifer Michalowski — Mon, 04 Oct 2021 17:00:02 +0000

Biologists at ��ϳԹ��Դ (CSHL) are using a mathematical approach developed in CSHL Assistant Professor David McCandlish’s lab to find solutions to a diverse set of biological problems. Originally created as a way to understand interactions between different mutations in proteins, the tool is now being used by McCandlish and his collaborators to...

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CSHL SBS graduation: Ceremony canceled, graduates undaunted

Jasmine Lee — Mon, 23 Aug 2021 20:00:39 +0000

In August 2021, ��ϳԹ��Դ (CSHL) School of Biological Sciences (SBS) awarded Doctor of Philosophy degrees to seven 2021 graduates. Additionally, distinguished academics Tania A. Baker and Mark Ptashne accepted honorary SBS degrees. The School originally planned to host a commencement ceremony to honor both 2021 and 2020 graduates (SBS had canceled the...

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Cancer cells pick and choose chromosomes to survive

Luis Sandoval — Wed, 18 Aug 2021 12:00:50 +0000

Chromosomes, the genetic material of our cells, are normally copied and distributed equally between two dividing cells. The cell division process is carefully regulated; losing a chromosome can be fatal or crippling for a cell. But ��ϳԹ��Դ (CSHL) Fellow Jason Sheltzer and his team discovered that cancer cells shed or double chromosomes...

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On the wrong side of cell division

Eliene Augenbraun — Fri, 13 Aug 2021 12:00:44 +0000

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Research matters

Communications Department — Tue, 08 Jun 2021 18:00:08 +0000

When SARS-CoV-2 (coronavirus) spread throughout the world, 2020 immediately became a historic year. The virus recognized no boundaries; neither physical nor political. Our Cold Spring Harbor Asia conference center employees in Suzhou, China, were the first affected by the pandemic, and soon thereafter, in March, we faced COVID-19 in New York. Like people everywhere, Cold...

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How an antiviral drug can flatten the curve…in your cells

Luis Sandoval — Fri, 09 Apr 2021 12:30:51 +0000

Camostat mesylate is an antiviral drug in clinical trials for treating COVID-19. ��ϳԹ��Դ Fellow Jason Sheltzer and University of Göttingen Professor Stefan Pöhlmann investigated how this drug prevents the virus from entering and spreading from cell to cell. SARS-CoV-2 infects our lung cells with the help of a cell surface protein called...

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CSHL wins ACS grant based on crowdsourced support

Luis Sandoval — Thu, 04 Feb 2021 21:00:04 +0000

��ϳԹ��Դ Fellow Jason Sheltzer has been awarded a TheoryLab Collaborative Grant from the American Cancer Society (ACS). TheoryLab™ is a new social media platform that allows cancer researchers to connect and launch collaborative projects. Sheltzer partnered with fellow TheoryLab™ user Rajan Kulkarni, an associate professor at Oregon Health Science University, for this...

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Why we’re a lot better at fighting cancer than we realized

Communications Department — Wed, 12 Aug 2020 15:00:23 +0000

In their long-running effort to defeat cancer, medical researchers have made a startling discovery: A lot of the time, they have no idea how their anti-cancer drugs work. And, strange as it may sound, that is actually great news for future therapies. “We’re not saying these drugs aren’t good,” explains Ann Lin, a geneticist at...

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Smoking increases SARS-CoV-2 receptors in the lung

Jennifer Michalowski — Mon, 18 May 2020 17:17:55 +0000

New research from CSHL scientists suggests that cigarette smoke spurs the lungs to make more ACE2 (angiotensin-converting enzyme 2), the protein that the coronavirus responsible for COVID-19 grabs and uses to enter human cells. The findings, reported May 16, 2020 in the journal Developmental Cell, may explain why smokers appear to be particularly vulnerable to...

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Carol Greider: Nobel Prize-winning rogue biologist

Brian Stallard — Tue, 31 Mar 2020 18:50:11 +0000

Dr. Carol Greider proudly calls herself a “rogue scientist.” That iconoclastic approach led to her Nobel Prize-winning work on telomeres, and to becoming a champion for women in science. “You can do whatever you want, but you have to like whatever you do.” That’s what Carolyn “Carol” Greider’s father told her when she was growing...

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Extra chromosomes in cancers can be good or bad

Jennifer Michalowski — Mon, 24 Feb 2020 16:00:55 +0000

Cancer cells are notorious for their genetic disarray. A tumor cell can contain an abundance of DNA mutations and most have the wrong number of chromosomes. A missing or extra copy of a single chromosome creates an imbalance called aneuploidy, which can skew the activity of hundreds or thousands of genes. As cancer progresses, so...

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Ann Lin named in Forbes 30 Under 30 list for 2020

Sara Roncero-Menendez — Mon, 16 Dec 2019 14:00:04 +0000

Ann Lin, a former intern in the lab of CSHL Fellow Jason Sheltzer, has been named one of the top entrepreneurs of the Forbes 30 Under 30 2020 list. She is one of the youngest winners in the Science category. As part of the Sheltzer lab, she helped discover that a successful cancer drug didn’t...

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Scientists take action to prevent sexual harassment and bias

Charlotte Hu — Thu, 07 Nov 2019 19:00:45 +0000

A diverse group of scientists gathered last December at the Banbury Center in Cold Spring Harbor, NY, to confront how institutions and funding agencies can prevent sexual harassment and gender bias in the STEM workforce. The conclusions from the meeting are highlighted in a new paper published in Science, which included 23 authors from a...

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Nobel laureate William Kaelin draws a crowd

Charlotte Hu — Tue, 29 Oct 2019 15:17:18 +0000

cientists and students packed Grace Auditorium at ��ϳԹ��Դ on October 17, filling almost every seat to hear the latest in cancer research from William Kaelin, who just 10 days before was awarded the Nobel Prize in Physiology or Medicine. Kaelin, a Professor of Medicine at Harvard Medical School and Dana-Farber Cancer Institute,...

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Cancer drugs don’t always work as intended, researchers warn

Brian Stallard — Wed, 11 Sep 2019 18:00:16 +0000

Scientists at ��ϳԹ��Դ (CSHL) have identified 10 cancer drugs currently in clinical trials that do not work how clinicians thought they would. In identifying what went wrong, experts can now work to improve drug discovery and personalized medicine. The discovery started out with an entirely different goal. Over the past few years,...

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Sheltzer wins Presidential Early Career Award

Sara Roncero-Menendez — Tue, 09 Jul 2019 17:16:50 +0000

��ϳԹ��Դ (CSHL) Fellow Jason Sheltzer has been named a recipient of the 2019 Presidential Early Career Award for Scientists and Engineers (PECASE). The award honors researchers early in their independent careers who show exceptional promise for leadership in science and technology. “Congratulations to Jason Sheltzer on being selected as a prestigious Presidential...

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CSHL Fellow Jason Sheltzer wins innovation award

Sara Roncero-Menendez — Fri, 25 Jan 2019 21:46:41 +0000

��ϳԹ��Դ (CSHL) Fellow Jason Sheltzer has been named a recipient of the Damon Runyon-Rachleff Innovation Award. The award funds cancer research pursued by exceptionally creative thinkers with “high-risk/high-reward” ideas, who lack sufficient preliminary data to obtain traditional funding. Sheltzer was awarded for his research on aneuploidy and cancer. This year, Damon Runyon...

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The year of CRISPR

Brian Stallard — Wed, 26 Dec 2018 20:33:53 +0000

It’s hard to have missed the acronym CRISPR this year! Headlines in the news have heralded game changing possibilities in biomedicine. Controversy and debate continue to sizzle worldwide among scientists and policymakers over the ethical implications of gene editing in humans. At ��ϳԹ��Դ (CSHL), though, CRISPR isn’t just about headlines. It is...

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Jason Sheltzer Archives | ���ϳԹ���Դ