genetics research Archives | ��ϳԹ��Դ

Enter the CRISPR frontier

Communications Department — Mon, 08 Sep 2025 11:30:33 +0000

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The CRISPR revolution continues

Nick Wurm — Tue, 12 Aug 2025 18:13:47 +0000

CRISPR-Cas9 gene editing revolutionized biological and biomedical research virtually overnight. The versatile tool has been used to improve crop yields and cure previously uncurable conditions like sickle cell anemia. In May 2025, the Nobel Prize-winning technology brought about another major biomedical breakthrough, as Kiran Musunuru and Rebecca Ahrens-Nicklas introduced the first personalized CRISPR gene editing...

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Branching out: Tomato genes point to new medicines

Samuel Diamond — Wed, 09 Jul 2025 15:00:49 +0000

Picture juicy red tomatoes on the vine. What do you see? Some tomato varieties have straight vines. Others are branched. The question is why. New research from ��ϳԹ��Դ (CSHL) provides the strongest evidence to date that the answer lies in what are called cryptic mutations. The findings have implications for agriculture and...

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At the Lab: The human Microprocessor

Communications Department — Tue, 27 May 2025 11:30:11 +0000

In biology, the phrase “molecular machinery” gets tossed around pretty regularly. But this week At the Lab, we’re talking about a particular molecular machine that truly earns the title. Join CSHL Professor & HHMI Investigator Leemor Joshua-Tor as she breaks down the crucial functions of Microprocessor.

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At the Lab Season 1 Research Rewind: Genetics

Communications Department — Tue, 22 Oct 2024 11:30:28 +0000

Much of what makes humans human is also found across all animal and plant life. In other words, genetics is everywhere you look. That’s especially true here At the Lab. This week’s Research Rewind features scientists from all across CSHL, including Christopher Hammell, Ivan Iossifov, Tobias Janowitz, Zachary Lippman, and Rob Martienssen. We also check...

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Adrian Krainer wins Albany Prize for biomedical research

Luis Sandoval — Tue, 08 Oct 2024 15:00:21 +0000

��ϳԹ��Դ (CSHL) Professor Adrian Krainer has won the Albany Prize, one of America’s largest awards for biomedical research. He now joins a prestigious list of recipients that includes names like Anthony Fauci, Emmanuelle Charpentier, and Jennifer Doudna. The Albany Prize recognizes scientists whose work has translated from “the bench to the bedside.”...

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From cancer genetics to cancer treatments

Jen A. Miller — Thu, 18 Jan 2024 12:30:49 +0000

What is cancer? How does it develop and spread? And how do we stop it? Thanks to science, today’s doctors can better answer all of these questions. That’s not because of one eureka moment. Instead, it’s the result of thousands of discoveries that built upon each other. Case in point: two of the most important...

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Penicillin: From limited wonder drug to worldwide lifesaver

Jen A. Miller — Wed, 10 Jan 2024 12:30:00 +0000

Penicillium mold with X-rays. Incredibly, the mutated strain was able to produce double the penicillin. Demerec’s breakthrough led to research that allowed the U.S. to ramp up production of this much-needed medicine. Penicillium image: © sinhyu - stock.adobe.com." data-description="" />Penicillin changed the world. The drug turned infections that had threatened lives into something that could be cured with a shot. But there was a catch. It only worked if you could get it and distribute it. During World War II, the U.S. military could not. That was until discoveries at ��ϳԹ��Դ...

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Reactivate, repurpose, and rewire the brain

Jennifer Michalowski — Wed, 04 Oct 2023 11:30:29 +0000

Developing brains become shaped by the sights, sounds, and experiences of early life. The brain’s circuits grow more stable as we age. However, some experiences later in life open up opportunities for these circuits to be rapidly rewired. New research from ��ϳԹ��Դ Associate Professor Stephen Shea helps explain how the brain adapts...

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Gene editing’s rocky start and groundbreaking legacy

Nick Wurm — Wed, 13 Sep 2023 11:30:52 +0000

Over 50 years ago, the first recombinant DNA experiments brought genome editing out of the realm of science fiction and into the mainstream. Recombinant DNA (rDNA) is a hybrid molecule made by combining DNA from two different species. Its arrival opened a Pandora’s box. Some feared it could lead to mutant viruses able to wipe...

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Where did our DNA come from?

Nick Wurm — Tue, 22 Aug 2023 11:30:21 +0000

About half of the human genome isn’t quite human. It’s made up of transposable elements (TEs)—descendants of ancient viruses. As a Ph.D. student at the Max-Delbrück Center for Molecular Medicine, Andrea Schorn studied an ancient TE that was resurrected from fish and is active in pretty much all vertebrates—except fish. Today, Schorn is an assistant...

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Humans of Banbury: Interview with Vardit Ravitsky

Jenna Jacobs — Wed, 01 Mar 2023 15:45:36 +0000

During the Banbury Center’s December 2022 meeting, “Developing an Ethical Framework for Human Research in Private Spaceflight,” I had the opportunity to meet with Vardit Ravitsky, Ph.D. Dr. Ravitsky is full professor of Bioethics at the University of Montreal’s School of Public Health, and senior lecturer on Global Health and Social Medicine at Harvard Medical...

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Cancer lab makes surprise discoveries in heart disease

Margaret Osborne — Wed, 30 Nov 2022 12:30:45 +0000

Sometimes science can lead to unexpected discoveries in unexpected places. That’s what ��ϳԹ��Դ (CSHL) Professor David Spector experienced this year. For nearly four decades, Spector has been researching cancer—the United States’ second-leading cause of death. But this year, he found himself studying the first—heart disease. Spector’s research at CSHL focuses on how...

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Welcome to Biology + Beyond

Communications Department — Tue, 15 Nov 2022 00:30:05 +0000

Nautilus magazine illustrates how CSHL is breaking new ground in the world of biology and beyond. A multidisciplinary perspective drives our research, and this issue highlights the intersections of those scientific disciplines." data-description="" />« Table of Contents Next Story » Welcome to a special edition of Biology + Beyond, a storytelling collaboration between ��ϳԹ��Դ (CSHL) and Nautilus that invites you to discover the many ways biological research impacts our lives. We’re very excited about the wide range of topics in this issue, which showcase the...

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Reversing a genetic cause of poor stress responses in mice

Jasmine Lee — Wed, 07 Apr 2021 15:00:06 +0000

Ophn1 gene causes mice to respond to stressful situations with an inappropriate helpless behavior. CSHL Professor Linda Van Aelst and her lab wanted to know the exact location in the mouse brain affected by the lack of Ophn1 that leads to this helpless/depressive behavior. In this image of a mouse brain, the green color shows the prelimbic region of the medial prefrontal cortex, where the researchers injected a virus to delete Ophn1. Ophn1 (red) is still present in other parts of the brain. The researchers discovered that deleting the gene in only this part of the brain caused the observed failure in stress adaptation. Human brains are organized similarly, so their findings in mice may be applicable to helping human patients who experience an inability to deal with stressful situations. Image: Minghui Wang/Van Aelst Lab." data-description="" />Everyone faces stress occasionally, whether in school, at work, or during a global pandemic. However, some cannot cope as well as others. In a few cases, the cause is genetic. In humans, mutations in the OPHN1 gene cause a rare X-linked disease that includes poor stress tolerance. ��ϳԹ��Դ (CSHL) Professor Linda Van...

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CSHL professor weighs in: Are CRISPR plants GMOs?

Eliene Augenbraun — Mon, 15 Mar 2021 12:30:19 +0000

The Nobel Prize-winning gene editing tool CRISPR/Cas9 is revolutionizing agriculture and adding a new dimension to the policy debate over how governments classify GMOs (genetically modified organisms). In a break from the European Union, which historically has tightly regulated genetically modified foods, the UK government has proposed regulating CRISPR crops far less stringently than previous...

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The complete human genome: A “book of life”

Jasmine Lee — Wed, 24 Feb 2021 16:00:28 +0000

The human genome has been referred to as the “book of life,” containing all the necessary instructions to build a human being. After years of bouncing around the idea of spelling out this “book,” a group of biologists met at the ��ϳԹ��Դ (CSHL) Banbury Center in 1989 to devise a concrete plan...

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CSHL President Bruce Stillman wins Heineken Prize

Sara Roncero-Menendez — Tue, 02 Jun 2020 08:00:05 +0000

��ϳԹ��Դ (CSHL) President and CEO Bruce Stillman has been awarded the Dr. H.P. Heineken Prize for Biochemistry and Biophysics. Stillman is being honored for his ground-breaking research on the way DNA is copied in eukaryotic cells, a crucial component to understanding genetics. The Dr. H.P. Heineken Prize for Biochemistry and Biophysics is...

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New faculty Jeff Boyd studies breast cancer genomics

Sara Roncero-Menendez — Thu, 26 Mar 2020 17:57:45 +0000

In partnership with Northwell Health, molecular biologist Jeff Boyd joins the ��ϳԹ��Դ faculty to better understand the basic biology of cancer. He is working on the genomics of gynecologic and breast cancer, with a focus on two novel hypotheses concerning breast cancer development. His research focuses on the early natural histories of...

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Shifting the balance of growth vs. defense boosts crop yield

Jennifer Michalowski — Thu, 19 Dec 2019 18:03:51 +0000

��ϳԹ��Դ (CSHL) scientists are figuring out how to pack more kernels onto a corn cob. One way to boost the productivity of a plant, they say, is to redirect some of its resources away from maintaining an overprepared immune system and into enhanced seed production. Now, a team led by CSHL Professor...

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genetics research Archives | ���ϳԹ���Դ